Orbital perspective on high-harmonic generation from solids.

High-harmonic generation in solids allows probing and controlling electron dynamics in crystals on few femtosecond timescales, paving the way to lightwave electronics. In the spatial domain, recent advances in the real-space interpretation of high-harmonic emission in solids allows imaging the field-free, static, potential of the valence electrons with picometer resolution. The combination of such extreme spatial and temporal resolutions to measure and control strong-field dynamics in solids at the atomic scale is poised to unlock a new frontier of lightwave electronics. Here, we report a strong intensity-dependent anisotropy in the high-harmonic generation from ReS2 that we attribute to angle-dependent interference of currents from the different atoms in the unit cell. Furthermore, we demonstrate how the laser parameters control the relative contribution of these atoms to the high-harmonic emission. Our findings provide an unprecedented atomic perspective on strong-field dynamics in crystals, revealing key factors to consider in the route towards developing efficient harmonic emitters.

Autonomic nervous system dysfunction in pediatric sport-related concussion: a systematic review.

Objective: To identify, appraise and synthesize the evidence of autonomic nervous system (ANS) dysfunction following sport-related concussion in pediatric populations. Methods: A literature search was conducted using MEDLINE (Ovid), SportDiscus (EBSCO), CINAHL (EBSCO), EMBASE (Ovid) and PsycINFO (Ovid). Studies were selected and appraised using the Joanna Briggs Institute (JBI) critical appraisal tools. Data was extracted from the included studies and qualitatively synthesized. Results: Eleven studies were included in the synthesis. There was variability in the methods used to measure ANS function between studies, and sample populations and time to assessment following concussion varied considerably. There was also variability in the direction of change of ANS function between some studies. Conclusion: This systematic review identifies that concussion is associated with dysregulation of ANS function in pediatric athletes. We identified some weaknesses in the extant literature which may be due to existing logistical and financial barriers to implementing valid ANS measurements in clinical and sports settings.

Objectif: Identifier, évaluer et synthétiser les preuves du dysfonctionnement du système nerveux végétatif (SNV) à la suite d'une commotion cérébrale liée au sport dans les populations pédiatriques. Méthodes: Une recherche documentaire a été effectuée sur MEDLINE (Ovid), SportDiscus (EBSCO), CINAHL (EBSCO), EMBASE (Ovid) et PsycINFO (Ovid). Les études ont été sélectionnées et évaluées à l'aide des outils d'évaluation critique du JBI (Joanna Briggs Institute). Les données ont été extraites des études incluses et ont fait l'objet d'une synthèse qualitative. Résultats: Onze études ont été incluses dans la synthèse. Les méthodes utilisées pour mesurer la fonction du SNV varient d'une étude à l'autre, et les populations d'échantillons ainsi que le délai d'évaluation après une commotion cérébrale varient considérablement. La direction du changement de la fonction du SNV variait également d'une étude à l'autre. Conclusion: Cette étude systématique montre que les commotions cérébrales sont associées à une dysrégulation de la fonction du SNV chez les athlètes enfants. Nous avons identifié certaines faiblesses dans la littérature existante, qui peuvent être dues aux obstacles logistiques et financiers existants pour mettre en oeuvre des mesures valides du SNV dans les environnements cliniques et sportifs.

Assessing construct validity of the Beighton Score as a measure of generalized joint hypermobility in varsity athletes.

The Beighton Score (BS) is a tool that dichotomizes those who have generalized joint hypermobility (GJH) and those who do not. Unfortunately, the BS is often used in populations that it was not originally developed for, including athletes for screening purposes. The construct validity of the BS remains unknown in this population. This secondary analysis investigated the construct validity of the BS by comparing varsity athletes' passive shoulder and hip ranges of motion (ROMs) to their respective BS and individual forward bend tests (FBTs). There were statistically significant but weak correlations between shoulder ROMs and the BS (r=0.142, p=0.021). Mean hip ROMs were greater by 5-degrees in those with positive FBTs compared to those with negative FBTs. This difference falls within typical measurement errors that occur in practice. Therefore, our results do not support the construct validity of the BS as a measure of GJH in healthy athletes.

Le score de Beighton (BS) est un outil qui permet de distinguer les personnes souffrant d'hypermobilité articulaire généralisée de celles qui n'en souffrent pas. Malheureusement, le score de Beighton est souvent utilisé dans des populations pour lesquelles il n'a pas été conçu à l'origine, notamment les athlètes, à des fins de dépistage. La validité de construit du score de Beighton reste inconnue dans cette population. Cette analyse secondaire a étudié la validité conceptuelle du score de Beighton en comparant les amplitudes de mouvement passives de l'épaule et de la hanche des athlètes universitaires à leur score de Beighton et à leurs tests individuels de flexion avant. Des corrélations statistiquement significatives mais faibles ont été observées entre les amplitudes de mouvement des épaules et le score de Beighton (r=0,142, p=0,021). Les amplitudes moyennes de flexion de la hanche étaient supérieures de 5 degrés chez les personnes ayant subi un test de flexion avant positif par rapport à celles ayant subi un test de flexion avant négatif. Cette différence s'inscrit dans le cadre des erreurs de mesure typiques qui se produisent au cours de la pratique. Par conséquent, nos résultats ne confirment pas la validité conceptuelle du score de Beighton en tant que mesure de l'hypermobilité articulaire généralisée chez les athlètes en bonne santé.

ALVAC-fIL2, a feline interleukin-2 immunomodulator, as a treatment for sarcoids in horses: A pilot study.

BACKGROUND: Sarcoid tumors are common in horses and may negatively impact the performance and value of the horse. No known treatment is reliably successful. HYPOTHESES/OBJECTIVES: To determine tolerability, overall response rate, time to response, and progression-free survival of horses with biopsy-confirmed or suspected sarcoids treated with ALVAC-fIL2. ANIMALS: Client-owned horses with measurable, presumed- or biopsy-confirmed sarcoid tumors. METHODS: Prospective pilot study. One milliliter of ALVAC-fIL2 was injected into 4 to 5 areas of the sarcoid(s) in each horse (week 0); this treatment was repeated in weeks 1, 3, and 7. Sarcoids were measured at each visit, and response to treatment was determined according to the Response Evaluation Criteria in Solid Tumors for dogs (v1.0). After the final treatment, horses were reassessed and sarcoids remeasured every 3 months until tumor progression or for a minimum of 1 year if progression was not documented. RESULTS: Fourteen horses were included. Tumor size decreased in 86% of the horses, and the median time to first response was 89 days (range, 34-406 days). Median time to best response was 211 days (range, 56-406 days), but 3 of the sarcoids still were decreasing in size at the time of final evaluation. The median progression-free interval was not reached. Adverse events were minimal and included transient focal inflammation in 2 horses. CONCLUSIONS AND CLINICAL IMPORTANCE: Intratumoral injection of ALVAC-fIL2 has promise as a well-tolerated and effective, tissue-sparing treatment for horses with sarcoid tumors.

Recognition and conservative management for a spectrum of sport-related scapholunate interosseous ligament injuries: a case series.

This case series presents four cases of scapholunate interosseous ligament (SLIL) injury. We discuss the process of early recognition and highlight difficulties encountered in current diagnostic and conservative management strategies. The cases profile interdisciplinary management of four scapholunate (SL) injuries that have different clinical presentations and injury mechanisms. Three sport-related SL injuries were managed conservatively by a sport specialist chiropractor and one sport-related case was self-managed. Management strategies included early wrist immobilization, soft tissue manual therapy, low-level laser therapy, proprioceptive and strengthening exercises, and early orthopedic referral. This case series highlights: (1) the spectrum of SL injuries (2) the importance of early specialty referral, (3) the paucity of literature with respect to conservative management of these injuries and (4) the role of manual therapy and rehabilitation professionals as part of the healthcare team in detecting and helping manage these wrist injuries.

Cette série de cas présente quatre cas de blessures du ligament interosseux scapho-lunaire (LISL). Nous discutons du processus de reconnaissance précoce et soulignons les difficultés rencontrées dans les stratégies actuelles de diagnostic et de gestion conservatrice. Ces cas illustrent la prise en charge interdisciplinaire de quatre lésions du ligament scapho-lunaire (SL) dont les tableaux cliniques et les mécanismes de blessure sont différents. Trois lésions scapho-lunaires liées au sport ont été prises en charge de manière conservatrice par un chiropraticien spécialiste du sport et un cas lié au sport a été auto-soigné. Les stratégies de prise en charge comprenaient une immobilisation précoce du poignet, une thérapie manuelle des tissus mous, une thérapie par laser à faible niveau, des exercices proprioceptifs et de renforcement, et une demande de consultation d'un orthopédiste le plus tôt possible. Cette série de cas met en évidence : (1) le spectre des lésions du ligament scapho-lunaire, (2) l'importance d'une orientation précoce vers un spécialiste, (3) la rareté des documents scientifiques concernant la gestion conservatrice de ces blessures et (4) le rôle des professionnels de la thérapie manuelle et de la réadaptation en tant que membres de l'équipe de soins de santé dans la détection et la gestion de ces blessures du poignet.

The effect of acute exercise for reducing cognitive alterations associated with individuals high in anxiety.

Single bouts of exercise have been observed to exhibit therapeutic benefits for reducing affective responses associated with anxiety. However, anxiety has also been found to relate to less efficient cognitive processing as well as a greater reliance on action monitoring processes. Given the extant body of evidence demonstrating that single bouts of exercise result in cognitive enhancements; the present investigation sought to determine the extent to which exercise might be effective at reducing these anxiety-related impairments in cognition. Using a randomized within-subjects crossover design in a sample of high-anxious and low-anxious college-aged adults, measures of inhibition, attention, and action monitoring were assessed before and after 20-min of either aerobic exercise or a cognitively engaging control condition during two separate, counterbalanced sessions. Findings from this investigation revealed that both high anxious and low anxious individuals exhibited enhancements in behavioral indices of performance on an inhibitory control task with faster and more accurate responses following 20 min of moderate intensity aerobic exercise. Additionally, both high anxious and low anxious individuals demonstrated exercise induced enhancements in the allocation of attentional resources (as indexed by P3 amplitude) as well as action monitoring (as indexed by ERN amplitude). Accordingly, these findings provide evidence consistent with broad-base claims regarding the benefits of exercise, suggesting that both high and low anxious individuals appear to incur cognitive benefits.

5th generation vs 4th generation troponin T in predicting major adverse cardiovascular events and all-cause mortality in patients hospitalized for non-cardiac indications: A cohort study.

OBJECTIVE: The frequency and implications of an elevated cardiac troponin (4th or 5th generation TnT) in patients outside of the emergency department or presenting with non-cardiac conditions is unclear. METHODS: Consecutive patients aged 18 years or older admitted for a primary non-cardiac condition who had the 4th generation TnT drawn had the 5th generation TnT run on the residual blood sample. Primary and secondary outcomes were all-cause mortality (ACM) and major adverse cardiovascular events (MACE) respectively at 1 year. RESULTS: 918 patients were included (mean age 59.8 years, 55% male) in the cohort. 69% had elevated 5th generation TnT while 46% had elevated 4th generation TnT. 5th generation TnT was more sensitive and less specific than 4th generation TnT in predicting both ACM and MACE. The sensitivities for the 5th generation TnT assay were 85% for ACM and 90% for MACE rates, compared to 65% and 70% respectively for the 4th generation assay. 5th generation TnT positive patients that were missed by 4th generation TnT had a higher risk of ACM (27.5%) than patients with both assays negative (27.5% vs 11.1%, p<0.001), but lower than patients who had both assay positive (42.1%). MACE rates were not better stratified using the 5th generation TnT assay. CONCLUSIONS: In patients admitted for a non-cardiac condition, 5th generation TnT is more sensitive although less specific in predicting MACE and ACM. 5th generation TnT identifies an intermediate risk group for ACM previously missed with the 4th generation assay.

Evaluation of surgical models for training veterinary students to perform enterotomies.

OBJECTIVE: To compare surgical models for teaching enterotomies to students. STUDY DESIGN: Prospective, randomized study. SAMPLE POPULATION: Second-year veterinary students (n = 59) and faculty surgeons/surgery residents (n = 19). METHODS: Participants performed an enterotomy on each of 3 models (equine cadaver intestine, SurgiReal small intestine simulator, and SynDaver canine bowel) and completed a survey comparing them to either an enterotomy on an anesthetized pig (students) or intestinal surgery experience (faculty/residents). Surveys results were compiled and analyzed. RESULTS: Both student and faculty/resident groups rated cadaver intestine as more similar to live intestine compared with the synthetic models for incision, tissue handling, mucosal eversion, needle passage, knot tying, and best preparing for live intestine. Students rated SynDaver as more similar to live intestine than SurgiReal for incision and ranked SurgiReal as more similar to live intestine than SynDaver for mucosal eversion. There was no difference between the ranks assigned to SurgiReal and SynDaver for faculty/residents. Faculty/residents responded most often that cadaver intestine would be the model they recommend for training students. CONCLUSION: Cadaver intestine was the model most similar to live intestine for all variables tested. SurgiReal and SynDaver models were comparable to each other but did not simulate live intestine as well as cadaver intestine. CLINICAL SIGNIFICANCE: Cadaver intestine more closely approximated live intestine compared with either synthetic model. SurgiReal and SynDaver may be adequate alternatives if cadaver intestine is unavailable.

Reliability and Validity of Commercially Available Low-Cost Bioelectrical Impedance Analysis.

Research comparing portable body composition methods, such as bioelectrical impedance analysis (BIA), to air displacement plethysmography (ADP) is limited. We assessed reliability and validity of predicting fat-free mass (FFM) by the RJL, Omron, and Tanita BIA machines using ADP via BodPod as a criterion. FFM (kg) was assessed twice in college students (N = 77, 31 males and 46 females; age = 19.1 ± 1.2 years) using ADP, RJL, Omron, and Tanita BIAs. Reliability was assessed using analysis of variance to obtain an intraclass correlation statistic (Rxx). Validity was assessed using Pearson correlation (r) coefficient. FFM averaged 75.6 ± 9.4 kg in men and 59.8 ± 7.6 kg in women. Reliability was high in both genders RJL (Rxx = .974-.994), Omron (Rxx = .933-.993), and Tanita (Rxx = .921-.991). Validity within males was also high: RJL (r = .935), Omron (r = .942), and Tanita (r = .934), and only slightly lower in females: RJL (r = .924), Omron (r = .897), and Tanita (r = .898). The RJL, Omron, and Tanita BIA machines appear to be both reliable and valid for predicting FFM of male and female college students. Therefore, any of these three BIA devices is appropriate to use for body composition assessment in a healthy adult population.

Agricultural Animals as Biomedical Models: Occupational Health and Safety Considerations.

The use of agricultural animals in biomedical research is increasing. Their overall size and metabolic rate, organ size, longer gestation period, and other physiological similarities make them good candidates for animal models of human disease. There are a number of special considerations for use of traditional farm animals for biomedical research. Differences in physical plant infrastructure, handling equipment, training of personnel, and potential zoonoses are some of the important considerations when traditional farm animals are used in biomedical research. This article provides an overview of some of the special considerations for using traditional agricultural animals in biomedical research. With the growing need for improved translational research, it is reasonable to predict significant growth in these animal models.

Preliminary evidence for differential trajectories of recovery for cognitive flexibility following sports-related concussion.

OBJECTIVE: A critical barrier to the understanding of disruptions to cognitive flexibility following sports-related concussion is the use of assessments that conflate shifts of visuospatial attention and contextual rules. Because these dissociable forms of cognitive flexibility are subserved by distinct neural networks, the utility of a cognitive flexibility assessment following concussion may be reduced, depending upon the extent to which the task requires shifting visuospatial attention relative to shifting contextual rules. Accordingly, the current investigation examined the extent to which these aspects of cognitive flexibility exhibit differential trajectories of recovery following a sports-related concussion. METHOD: Twenty-two athletes with sports-related concussions were assessed on a cognitive flexibility task with 2 switch conditions (i.e., perceptual-based and contextual rule-based) within 72 hr of injury, after return to play, and within 1 month following return to play. Thirty-three healthy control athletes were tested at the same intervals. RESULTS: Findings revealed that concussed athletes demonstrated protracted disruptions in task performance on a visuospatial attention-based cognitive flexibility task relative to healthy controls, whereas disruptions in task performance on a contextual rule-based cognitive flexibility task resolved after the acute phase of injury. These findings suggest that dissociable forms of cognitive flexibility exhibit differential trajectories of recovery. CONCLUSIONS: Therefore, evaluations detecting sports-related concussion disruptions in cognitive flexibility may be reduced depending on the extent to which they rely on contextual rule-based decisions. Test batteries focusing on visuospatial attention-based demands may be useful additions to aid in the objective assessment and follow-up management of athletes following the acute phase of injury. (PsycINFO Database Record

Muscular and Aerobic Fitness, Working Memory, and Academic Achievement in Children.

PURPOSE: This study investigated the relationship between aerobic and muscular fitness with working memory and academic achievement in preadolescent children. METHODS: Seventy-nine 9- to 11-yr-old children completed an aerobic fitness assessment using a graded exercise test; a muscular fitness assessment consisting of upper body, lower body, and core exercises; a serial n-back task to assess working memory; and an academic achievement test of mathematics and reading. RESULTS: Hierarchical regression analyses indicated that after controlling for demographic variables (age, sex, grade, IQ, socioeconomic status), aerobic fitness was associated with greater response accuracy and d' in the 2-back condition and increased mathematic performance in algebraic functions. Muscular fitness was associated with increased response accuracy and d', and longer reaction time in the 2-back condition. Further, the associations of muscular fitness with response accuracy and d' in the 2-back condition were independent of aerobic fitness. CONCLUSION: The current findings suggest the differential relationships between the aerobic and the muscular aspects of physical fitness with working memory and academic achievement. With the majority of research focusing on childhood health benefits of aerobic fitness, this study suggests the importance of muscular fitness to cognitive health during preadolescence.

Variability of ICA decomposition may impact EEG signals when used to remove eyeblink artifacts.

Despite the growing use of independent component analysis (ICA) algorithms for isolating and removing eyeblink-related activity from EEG data, we have limited understanding of how variability associated with ICA uncertainty may be influencing the reconstructed EEG signal after removing the eyeblink artifact components. To characterize the magnitude of this ICA uncertainty and to understand the extent to which it may influence findings within ERP and EEG investigations, ICA decompositions of EEG data from 32 college-aged young adults were repeated 30 times for three popular ICA algorithms. Following each decomposition, eyeblink components were identified and removed. The remaining components were back-projected, and the resulting clean EEG data were further used to analyze ERPs. Findings revealed that ICA uncertainty results in variation in P3 amplitude as well as variation across all EEG sampling points, but differs across ICA algorithms as a function of the spatial location of the EEG channel. This investigation highlights the potential of ICA uncertainty to introduce additional sources of variance when the data are back-projected without artifact components. Careful selection of ICA algorithms and parameters can reduce the extent to which ICA uncertainty may introduce an additional source of variance within ERP/EEG studies.

The Association between Physical Activity During the Day and Long-Term Memory Stability.

Despite positive associations between chronic physical activity and memory; we have little understanding of how best to incorporate physical activity during the day to facilitate the consolidation of information into memory, nor even how time spent physically active during the day relates to memory processes. The purpose of this investigation was to examine the relation between physical activity during the day and long-term memory. Ninety-two young adults learned a list of paired-associate items and were tested on the items after a 12-hour interval during which heart rate was recorded continuously. Although the percentage of time spent active during the day was unrelated to memory, two critical physical activity periods were identified as relating to the maintenance of long-term memory. Engaging in physical activity during the period 1 to 2-hours following the encoding of information was observed to be detrimental to the maintenance of information in long-term memory. In contrast, physical activity during the period 1-hour prior to memory retrieval was associated with superior memory performance, likely due to enhanced retrieval processing. These findings provide initial evidence to suggest that long-term memory may be enhanced by more carefully attending to the relative timing of physical activity incorporated during the day.

The association between a history of concussion and variability in behavioral and neuroelectric indices of cognition.

Associations between a history of concussion and variability in behavioral and neuroelectric indices of cognition were assessed in college-aged adults with a history of concussion and a healthy control group, in response to a stimulus discrimination task and a more attentionally demanding flanker task. Greater intra-individual variability was observed only for behavioral indices of reaction time in response to the flanker task for those with a history of concussion. An association was also observed between the number of concussions resulting in a loss of consciousness and greater variability of reaction time regardless of the type of task. Relative to neuroelectric measures, a concussive history was associated with smaller P3 amplitude only in response to the flanker task; with no differences between groups observed in response to the oddball task or for intra-individual variability measures. Thus, increased variability associated with a history of concussion appears to be behavior and process specific. The behavioral metrics and functions assessed are important considerations for identifying subtle, yet persistent influences of concussion on cognitive performance. Further, factors such as loss of consciousness associated with a concussive injury may moderate the extent to which these increases in behavioral variability manifest. Thus, the identification of persistent cognitive impairment following concussive injuries necessitates the utilization of appropriate tasks and may be facilitated by going beyond behavioral measures of central tendency.

Single bouts of exercise selectively sustain attentional processes.

This study examined how single bouts of exercise may differentially modulate neuroelectric correlates of attentional orienting and processing. Using a within-participants design, ERPs and task performance were assessed in response to a perceptually challenging three-stimulus oddball task prior to and following a bout of exercise or seated rest during two separate, counterbalanced sessions. Findings revealed that, following a single bout of exercise, attentional processing was sustained relative to pretest whereas prolonged sitting resulted in attentional decrements. Focal attention resulting from attentional orienting, in contrast, does not appear to be sensitive to the influences of single bouts of physical activity. These findings suggest that acute exercise-induced changes in cognition do not originate from an overall modulation of attention but instead are specific to aspects of attentional processing.

VI. The role of physical activity in reducing barriers to learning in children with developmental disorders.

Emerging research suggests that physical activity may be an effective non-pharmaceutical intervention approach for childhood developmental disorders. Findings indicate that both single bouts of activity and chronic physical activity associate with improved mental health and classroom performance in children with attention-deficit/hyperactivity disorder and children with autism spectrum disorders. This review describes the research in this area and identifies limitations and challenges to the translation of these findings to promote physical activity in clinical practice and educational policy.

Poorer aerobic fitness relates to reduced integrity of multiple memory systems.

Epidemiological investigations have revealed increases in the prevalence of sedentary behaviors in industrialized societies. However, the implications of those lifestyle choices and related cardiorespiratory fitness levels for memory function are not well-understood. To determine the extent to which cardiorespiratory fitness relates to the integrity of multiple memory systems, a cross-sectional sample of young adults were tested over the course of 3 days in areas related to implicit memory, working memory, long-term memory, and aerobic fitness. Findings revealed an association between aerobic fitness and memory function such that individuals with lower cardiorespiratory fitness exhibited poorer implicit memory performance and poorer long-term memory retention. These data indicate that cardiorespiratory fitness may be important for the optimal function of neural networks underlying these memory systems.