Structural brain MR imaging changes associated with obsessive-compulsive disorder in patients with multiple sclerosis.

BACKGROUND AND PURPOSE: Psychiatric symptoms occur in approximately 30% of patients with MS. Such symptoms include OCD, which may interfere heavily with the patient's daily life. We hypothesized that the widespread involvement of both GM and WM, which characterizes MS, may be responsible for the occurrence of OCD when specific brain structures are affected. The aim of this study was to evaluate the relationship between GM and WM tissue damage and OCD in patients with MS. MATERIALS AND METHODS: We evaluated 16 patients with relapsing-remitting MS who had been diagnosed with OCD on the basis of the Diagnostic and Statistical Manual of Mental Disorders (4th edition) and 15 age- and sex-matched patients with relapsing-remitting MS with no psychiatric disorders as a CG. The MR study (1.5T) included 3D T1-weighted fast-field echo sequences, DTI (32 directions), and conventional MRI. Images were processed using SPM5, FSL, and Jim 5.0 software to evaluate VBM, TBSS, and global and regional LV, respectively. RESULTS: The VBM analysis revealed a set of clusters of reduced GM volume in the OCD group, compared with the CG, located in the right inferior and middle temporal gyri and in the inferior frontal gyrus. TBSS did not detect any differences in the FA values between the 2 groups; global and regional LV values also did not differ significantly between the 2 groups. CONCLUSIONS: Our study suggests that OCD in MS may be caused by damage in the right frontotemporal cortex.

[Normal values for the internal thoracic artery by Doppler ultrasound and modification of the Doppler curve after bypass to the left anterior descending artery]. / Duplexsonographische Normwerte der Arteria thoracica interna und Flussveränderungen nach minimal invasiver Anastomosierung (MIDCAB) auf den Ramus interventricularis anterior.

AIM: In coronary heart disease, the surgical therapy of choice is the construction of an artenal bypass of the left anterior descending artery (LAD) using the internal thoracic artery 8ITA). We define age dependent normal values for the ITA such as diameter of the lumen (LD), peak systolic (Vs) and diastolic (Vd) flow velocity and the ratio of these two values (SDR) measured by duplex ultrasound. Furthermore, the modification and pathological changes of the Doppler curve after minimal invasive bypass of the LAD (MIDCAB) are described. MATERIAL AND METHODS: 96 people, age 18 - 87 years, subdivided into 6 age groups were examined by duplex to define the normal values of the ITA, and 55 patients (mean age 63 +/- 10 years, 48 men, 7 women) were evaluated after MIDCAB-surgery to describe the postoperative modification of the Doppler curve. The examinations were performed using a 4 - 7 MHz linear ultrasound transducer in the right and left 1. or 2. intercostal space parasternally. RESULTS: In all 96 people, the ITA was detectable on both sides presenting a typical bi- or triphasic Doppler flow profile. A linear age dependent increase in the LD of 1.95 +/- 0.15 mm (right ITA) and 1.93 +/- 0.27 mm (left ITA) respectively to 2.65 +/- 0.48 mm and 2.55 +/- 0.43 mm was found. No significant side difference was found for Vs and Vd, nor were there any age dependent differences for Vs. The SDR showed an age dependent linear increase on the right side from 3.5 +/- 1.1 to 6.1 +/- 2.2, p < 0.0012, and on the left from 3.9 +/- 1.2 to 6.7 +/- 1.7, p < 0.0001. Postoperatively, the Doppler spectrum was modified into a mono- or biphasic Doppler curve with a reduced Vs and an increased Vd resulting in a significantly decreased SDR on the left side compared with the right side (1.3 +/- 0.8 vs. 5.4 +/- 2.0, p < 0.00001). Three patients with angiographically proven graft failure had an SDR of 2.6 - 5.2 (mean 3.8), as opposed to a value of < 2.0 in case of a patent bypass. An SDR > 2.0 has a sensitivity of 100 % and a specificity of 97 % in the detection of a haemodynamically relevant (>70 %) ITA-graft-stenosis. CONCLUSIONS: With rising age, there is an increase in the LD of the ITA and the peripheral resistance, expressed as SDR. After MIDCAB surgery the former triphasic Doppler flow curve changes into a mono- or biphasic curve corresponding to the coronary blood flow. An SDR >2.0 is a strong indicator of bypass failure.

Use of MIDCAB procedure for redo coronary artery bypass.

BACKGROUND: Reoperative coronary artery bypass grafting (CABG) procedures are growing in importance due to the increasing number of patients requiring another bypass operation. Conventional redo-procedures are associated with an increased mortality and morbidity. To reduce risk, minimally invasive direct coronary artery bypass (MIDCAB) using the left internal mammary artery (LIMA) to the left anterior descending branch (LAD) may be preferable, when indicated, in selected patients. We report a series of patients who underwent this procedure for redo-CABG in our center. METHODS: Since April 1997, 20 male patients who had undergone prior CABG using conventional procedure, were reoperated using the LIMA to LAD through a lateral minithoracotomy on the beating heart. Nineteen patients presented for a redo-CABG; one patient required a second-time redo-CABG. Two patients required concomitant PTCA of a second vessel as hybrid procedure. We reviewed these redo cases and studied their surgical results for mortality, morbidity, operation time, and hospital stay. RESULTS: Mean operation time was 139 min (90-180). Four patients were extubated directly postoperatively; the others had a short period of ventilatory support. There was no myocardial infarction, no deaths or need of inotropic support postoperatively. No patient required re-exploration for bleeding. All patients could be mobilized and discharged early. At present, all patients are living and classified as CCS class I or II. CONCLUSIONS: Our results indicate that MIDCAB using IMA grafts for reoperation is a safe procedure with low risk for morbidity and mortality. This surgical technique is a useful alternative to conventional redo CABG in selected patients when complete revascularisation is not indicated.

A longitudinal study of velogenic Newcastle disease virus genotypes isolated in Italy between 1960 and 2000.

Thirty-six representative velogenic strains of Newcastle disease virus isolated in Italy since 1960 were characterized by restriction site and partial sequence analyses of the fusion protein gene. Viruses belonging to the six known genotypes of Lomniczi et al . were found. Genotype IV, which was most probably the main epizootic group in Europe before the war, was responsible for outbreaks in the 1960s and persisted until the late 1980s in Italy. An epizootic peak in 1972 to 1974 coincided with the appearance of genotype V viruses that were present for more than a decade. Outbreaks in 1992 were caused by genotype VIIa viruses and were part of a contemporaneous epizootic of Far East origin that affected Western European countries. The Newcastle disease epizootic that commenced in Italy in May 2000 was due to a genotype VIIb virus that is indistinguishable from those causing sporadic outbreaks in Great Britain and Northern Europe in the late 1990s. Isolated cases yielded a variant of genotype VI (reference epizootic: Middle East in the late 1960s) and a group VIII virus (enzootic in South Africa).

Adenovirus-associated haemorrhagic disease in guinea fowl.

Nine outbreaks of a disease affecting 2 to 5-month-old guinea fowl, characterized by slight depression and sudden deaths, are described. Gross haemorrhages in the serosa and muscles were constantly observed. Histologically nuclear inclusion bodies, similar to those observed in avian adenovirosis group II were detected in the spleen of affected animals. Electron microscopic examination revealed the presence of adenovirus particles in spleen ultra-thin sections. The agar-gel immunodiffusion test, carried out on the sera from one outbreak, demonstrated reacting antibodies with haemorrhagic enteritis virus of turkeys. The disease was experimentally reproduced inoculating 35-day-old guinea fowl with spleen homogenate from affected animals.

[Primary hyperaldosteronism: our experience with 34 patients]. / L'iperaldosteronismo primario: esperienza con 34 pazienti.

Primary aldosteronism (PA) is a relative new endocrine disease that account for almost 1-2% of the hypertensive population. In spite of the large number of reports there is still disagreement around the preoperative diagnosis and surgical treatment. In a nineteen year period from 1970 to 1989, 34 patients came to our Department with a diagnosis of Primary Aldosteronism. 18 patients were female. Mean age at time of diagnosis was 45.5 yrs. (range 27-67 yrs.). Mean follow-up was 71 months (range 1-227 months). Follow-up was achieved in all patient. Hypertension and hypokalemia were discovered in all patients. Three patients had extremely low values of potassium and presented severe metabolic, cardiac and neurologic troubles. Localization procedure techniques improved during this period of time and at this moment CAT scan appears to be the most accurate method. Flank incision was the approach of choice in all but four patients. No postoperative complications were recorded. Histology demonstrated an incidence of adenomas according to the literature. One patient had an adrenal carcinoma with functioning metastases. He was operated on several times in order to remove the functioning node metastases but finally died with widespread disease four years after the first surgical treatment. Another patient in this series died three years after the operation for an unrelated event. In 29 patients hypertension and hypokalemia disappeared while in two patient, one with an adrenal carcinoma hypertension increased. Primary aldosteronism is a rare endocrine disorder whose incidence is increased in the last years because of the improvement in diagnostic procedures.(ABSTRACT TRUNCATED AT 250 WORDS)

Cavernous sinus syndrome as the initial manifestation of multiple myeloma.

A 76-year-old man developed a cavernous sinus syndrome as the initial manifestation of multiple myeloma. Although clinically the patient had stage IA disease, which is typically associated with a favorable response to therapy, his disease was rapidly fatal. This case emphasizes a weakness of the traditional staging system because it does not take into account certain clinical and histopathologic aspects of myeloma relevant to extramedullary plasmacytomas. Since disorders of ocular motility are more likely to be associated with extramedullary myeloma than myeloma confined to the marrow, clinicians need to be aware of the limitations in the clinical staging system and the potential problems associated with anaplastic plasmacytomas.

Mycoplasma synoviae in the guinea-fowl.

A mycoplasma strain, isolated from natural synovitis of guinea-fowl, was identified as Mycoplasma synoviae. In experimental infection this agent showed clear pathogenicity for guinea-fowl, and to a lesser degree for chickens. In guinea-fowl the strain was more likely to result in synovitis and amyloidosis when inoculated by the intravenous route and to produce sinusitis after intrasinusal inoculation.