A rat model for the study of intestinal heterotopic gastropathy.

This study analyzes an experimental model for the study of reactions from gastric tissue exposed to enteric environment. Morphological studies were performed by histological, histochemical and immunohistochemical methods, using formalin-fixed biopsies of full-wall-thickness gastric implants in a whole-wall jejunal defect. These grafts suffered severe lesions, characterized by chronic atrophic gastritis, foveolar hyperplasia, glandular cystic transformation, and intestinal metaplasia. Increase in acidic mucins was also observed. There was no proliferating cell nuclear antigen (PCNA) overexpression. The results suggest that this model can be useful to investigate the heterotopic grastropathy and can be applied in further research studies.