Hearing shape.

In 4 experiments, participants listened to suspended occluded objects set into vibration by a pendular hammer. In Experiment 1, participants provided analogue measures of the heights and widths of 3 rectangular steel plates equal in area and weight. The same report method and rectangular dimensions were used in Experiment 2 with 3 plates each of steel, wood, and Plexiglas. Heights and widths were distinguished and perceived in similar proportions to the actual dimensions regardless of material composition. In Experiments 3 and 4, participants successfully identified circular, triangular, and rectangular plates of a single material (Experiment 3) and of 3 different materials (Experiment 4). Discussion focuses on the dependency of perceived dimensions on the physical properties and linear dimensions of the plates and the acoustic structure determined by the solutions to the 2-dimensional wave equation.

Coordination Dynamics of the Bipedal Galloping Pattern.

A motion equation in relative phase was developed that incorporates the spatial-temporal pattern of the bipedal gallop along with the more commonplace patterns of the bipedal jump and walk-run. In 3 experiments, human participants (N = 6 per experiment) simulated the bipedal gait patterns through the rhythmic motions of hand-held pendulums. Predictions of the motion equation for coordination equilibria and their respective degrees of stability were confirmed. In particular, the gallop pattern was less stable than the fundamental in-phase and antiphase patterns but changed in qualitatively similar ways to those gaits as a function of limb asymmetry and movement frequency. The relation between the modeled coordination dynamics and the kinematic characteristics of real bipedal galloping is discussed.

Transforming growth factor-alpha (TGF alpha) concentrations increase in regenerating rat liver: evidence for a delayed accumulation of mature TGF alpha.

Changes in the concentration of transforming growth factor-alpha (TGF alpha) protein were measured in regenerating liver. TGF alpha stimulates both DNA and protein synthesis in various liver-derived cells, and its mRNA levels increase in liver after partial hepatectomy (PH), suggesting that it may be an important autocrine regulator of liver regeneration. Using a sheep antiserum raised against mature rat TGF alpha, we developed a sensitive TGF alpha RIA. TGF alpha was extracted from livers in a detergent-containing buffer with protease inhibitors. Liver extracts, to a volume of 10 microliters/tube, produced a displacement curve of [125I]TGF alpha that was parallel to the pure standard. The TGF alpha content of normal liver was 57.04 +/- 26.25 pg/mg protein, 5.24 +/- 2.61 ng/mg DNA, and 10.33 +/- 4.47 ng/g liver (n = 5; mean +/- SD). Between 13-17 h after operation, TGF alpha concentrations in the livers of PH animals increased over those in sham-operated (SH) controls (P < 0.05) and remained twice those in SH controls for more than 96 h, returning to control values by 8 days. In unoperated liver, gel chromatography showed all TGF alpha immunoactivity to be in fractions corresponding to known TGF alpha precursors (15-30 kilodaltons). Mature 5.6-kilodalton TGF alpha was not detected until 48 h after PH and was still present at 96 h. These data support a role for TGF alpha in the response to PH in the rat. However, the presence of TGF alpha precursors in normal liver, the short (< 4-h) interval between the increase in TGF alpha concentrations and the onset of hepatocyte DNA synthesis, the sustained elevation of TGF alpha levels after DNA synthesis has ceased, and the lack of detectable processing to the mature form until DNA synthesis has subsided all suggest that the membrane-anchored precursor and the mature forms of TGF alpha may have different functions, cellular sources, or target cells in regenerating liver.

Soil-water potential: direct measurement by a new technique.

Current methods of measuring the potential of water in soil are inadequate. It is proposed to depress the reference free energy of water by a predetermined amount from the standard level of pure free water at atmospheric pressure by use of a solute. The specific free-energy difference of soil water from the depressed reference can be measured as a pressure.