The Antioxidant, Anti-Inflammatory and Moisturizing Effects of Camellia oleifera Oil and Its Potential Applications.

Camellia oleifera oil (CO oil) extracted from C. oleifera seeds has a 2300-year consumption history in China. However, there is relatively little research regarding its non-edible uses. This study determined the physicochemical properties of CO oil extracted via direct pressing, identified its main components using GC-MS, and evaluated its antioxidant, moisturizing, and anti-inflammatory activities. The results revealed that CO oil's acid, peroxide, iodine, and saponification values were 1.06 ± 0.031 mg/g, 0.24 ± 0.01 g/100 g, 65.14 ± 8.22 g/100 g, and 180.41 ± 5.60 mg/g, respectively. CO oil's tocopherol, polyphenol, and squalene contents were 82.21 ± 9.07 mg/kg, 181.37 ± 3.76 mg/kg, and 53.39 ± 6.58 mg/kg, respectively; its unsaturated fatty acid (UFA) content was 87.44%, and its saturated fatty acid (SFA) content was 12.56%. CO oil also demonstrated excellent moisture retention properties, anti-inflammatory effects, and certain free radical scavenging. A highly stable CO oil emulsion with competent microbiological detection was developed using formulation optimization. Using CO oil in the emulsion significantly improved the formulation's antioxidant and moisturizing properties compared with those of the emulsion formulation that did not include CO oil. The prepared emulsion was not cytotoxic to cells and could reduce cells' NO content; therefore, it may have potential nutritional value in medicine and cosmetics.

Hydroxylamine promoted degradation of organic contaminants using peroxydisulfate activated by Fe-alginate.

To overcome the shortcomings of Fe(Ⅱ)/peroxydisulfate (PDS) system including the limited working pH range and large iron sludge production, a Fe-doped alginate (Fe-Alg) catalyst was prepared and combined with hydroxylamine (HA) to continuously activate PDS for the removal of organic pollutants in neutral condition. Due to the strong reductive capability of HA, it could significantly enhance the catalytic capability of Fe-Alg for PDS. The results of characterization suggested that Fe(Ⅲ)/Fe(Ⅱ) was evenly distributed in Alg through its complexation with carboxyl groups, and the reduction of Fe(Ⅲ) to Fe(Ⅱ) initiated by HA enabled Orange G (OG) to be continuously degraded in the Fe-Alg/HA/PDS system. The results of quenching experiments suggested that SO4∙- and HO• played a dominant role for OG removal in the Fe-Alg/HA/PDS process. The effect of influence factors (e.g. initial pH, HA concentration, Fe-Alg dose and PDS concentration) and water matrix components (i.e. SO42-, NO3-, Cl-, HCO3- and dissolved organic matters (DOM)) on the performance of Fe-Alg/HA/PDS system was systematically investigated. Other refractory organic contaminants, including diclofenac (DCF), sulfamethoxazole (SMX), oxytetracycline (OTC) and bisphenol AF (BPAF) were also efficiently eliminated in Fe-Alg/HA/PDS system, suggesting the feasibility of this system for the treatment of organic pollutants. This work provides a method to optimize Fe(Ⅱ)/PDS system and a novel process applied to degrade refractory pollutants.

Emerging Trends and Research Foci in Tumor Microenvironment of Pancreatic Cancer: A Bibliometric and Visualized Study.

Background: Pancreatic cancer (PC) is a serious disease with high mortality. The tumor microenvironment plays a key role in the occurrence and development of PC. The purpose of this study is to analyze trends by year, country, institution, journal, reference and keyword in publications on the PC microenvironment and to predict future research hotspots. Methods: The Web of Science Core Collection was used to search for publications. We analyzed the contributions of various countries/regions, institutes, and authors and identified research hotspots and promising future trends using the CiteSpace and VOSviewer programs. We also summarized relevant completed clinical trials. Results: A total of 2,155 papers on the PC microenvironment published between 2011 and 2021 were included in the study. The number of publications has increased every year. The average number of citations per article was 32.69. The USA had the most publications, followed by China, and a total of 50 influential articles were identified through co-citation analysis. Clustering analysis revealed two clusters of keywords: basic research and clinical application. The co-occurrence cluster analysis showed glutamine metabolism, carcinoma-associated fibroblasts, oxidative phosphorylation as the highly concerned research topics of basic research in recently. The three latest hot topics in clinical application are liposomes, endoscopic ultrasound and photodynamic therapy. Conclusion: The number of publications and research interest have generally increased, and the USA has made prominent contributions to the study of the tumor microenvironment of PC. The current research hotspots mainly focus on energy metabolism in the hypoxic tumor microenvironment, cancer associated fibroblasts in regulating the tumor microenvironment, accurate diagnosis, drug delivery and new treatments.

Kinetics and reaction mechanism of photochemical degradation of diclofenac by UV-activated peroxymonosulfate.

Diclofenac (DCF) is a common non-steroidal anti-inflammatory drug, which is frequently detected in different environmental media such as surface water, groundwater, domestic sewage, and sediment. In this study, UV-activated peroxymonosulfate (PMS) was used to degrade DCF by generating active radicals (i.e., SO4˙- and HO˙) with strong oxidizing properties. The effects of PMS dosage, pH, initial DCF concentration and common water constituents on the removal of DCF as well as its degradation mechanism in UV/PMS system were investigated. Compared to UV alone and PMS alone systems, DCF was removed more efficiently in the UV/PMS system at pH 7.0 due to the contribution of SO4˙- and HO˙, and its degradation followed the pseudo-first order kinetic model. As the dosage of PMS or solution pH increased, the degradation efficiency of DCF was gradually enhanced. The highest DCF degradation was obtained at pH 11.0 in this study, because the molar absorption coefficient of PMS increased with increasing pH at 254 nm resulting in generation of more reactive radicals at high pH. Removal efficiency of DCF was decreased significantly with the increase in its initial concentration due to the insufficient concentration of radicals. The presence of HCO3 - and NO3 - could promote the degradation of DCF because of the role of carbonate radicals and extra HO˙ formed, respectively, while NOM inhibited DCF degradation due to its competition with DCF for reactive radicals. No obvious influence on DCF degradation was observed in the UV/PMS system with the addition of Cl- and SO4 2-. The degradation of DCF by UV/PMS in real waters was slightly suppressed compared with its removal in ultrapure water. Seven transformation products were detected using UPLC-QTOF/MS, and the potential degradation mechanism of DCF was thus proposed showing six reaction pathways including hydroxylation, decarboxylation, dechlorination-cyclization, formylation, dehydrogenation and dechlorination-hydrogenation.

Effect of molecular structure on the adsorption affinity of sulfonamides onto CNTs: Batch experiments and DFT calculations.

In order to investigate the adsorption behaviors of sulfonamides onto hydroxylated multi - walled carbon nanotubes (CNTs) with a porous structure and large specific surface area, six typical sulfonamides including sulfanilamide (SAM), sulfamerazine (SMR), sulfadimethoxine (SMX), sulfadiazine (SDZ), sulfamethazine (SMT) and sulfametoxydiazine (SMD) were selected to be adsorbed respectively on CNTs, and in the same time the structural parameters of the six sulfonamides molecules were calculated according to the density functional theory (DFT). Based upon above mentioned experiments and the structural parameters, the quantitative correlation between the structural parameters of sulfonamides molecules and their adsorption affinity (e.g. adsorption capacity and adsorption rate constant) onto CNTs was established, respectively. The adsorption data of sulfonamides fitted well with the pseudo - second - order kinetic model and the Langmuir isotherm model. The order of both pseudo - second - order kinetic constant and maximum adsorption capacity of the six sulfonamides were SAM < SMR < SMX < SDZ < SMT < SMD. The frontier molecular orbital energy (EHOMO) and dipole moment (µ) could be used as indicators for the adsorption affinity of sulfonamides onto CNTs. Accordingly, the possible adsorption mechanism was proposed.