Is there a superiority between arthrocentesis and stabilizing occlusal splint for the treatment of anterior disc displacement with reduction and intermittent block and anterior disc displacement without reduction in TMJ? Randomized clinical trial.

INTRODUCTION: Anterior displacement of the temporomandibular joint (TMJ) disc is a disorder in which the articular disc is dislocated from its correct position relative to the mandibular condyle and mandibular fossa. Traditionally, the initial treatment of disc displacements involves various conservative measures, including the use of a stabilizing interocclusal splint. However, in cases where there is associated limited mouth opening, as in the case of anterior disc displacement with reduction and intermittent block (ADDwRIB), and anterior disc displacement without reduction (ADDw/oR), arthrocentesis has been suggested as another modality of initial treatment due to its faster effect in preventing disease progression to a more advanced stage, as well as reducing the chances of pain chronification and central sensitization. OBJECTIVES: This study aimed to analyze whether there is a preponderance in efficacy between treatments with a stabilizing interocclusal splint or arthrocentesis in these patients. METHODS: A randomized, prospective, longitudinal clinical trial was conducted. The sample was obtained by convenience, between June 2021 and January 2023. Twenty-four patients with diagnoses of ADDwRIB and ADDw/oR were included. The diagnosis and clinical evaluations followed the DC/TMD criteria, and TMJ MRI was performed. Patients were randomly allocated to 2 treatment groups. Group 1 (n = 13): stabilizing interocclusal splint. Group 2 (n = 11): arthrocentesis. Patients were evaluated after 1, 2, 3, and 6 months for clinical parameters of pain, functionality, and psychosocial status. RESULTS: Both treatments were effective in reducing pain levels, with no statistically significant differences. Group 1 showed significantly greater mouth-opening levels compared to Group 2 (P = .041). CONCLUSION: Both groups showed significant improvements in various parameters evaluated throughout the study, indicating they are equally effective in pain control and most functional and quality of life parameters. However, the stabilizing interocclusal splint treatment was superior in restoring mouth opening.

Bone pattern changes in post liver transplant patients using bisphosphonates.

OBJECTIVE: To identify radiographic findings suggestive of drug-induced osteonecrosis and evaluate radiomorphometric patterns indicative of changes in bone mineral density in individuals transplanted for liver disorders using bisphosphonates. STUDY DESIGN: The study group included panoramic x-rays of liver transplant patients who are being monitored and who present a clinical status of osteoporosis and use bisphosphonates. The control group was made up of liver transplant patients who did not have osteoporosis. On panoramic radiographs, mental index (MI) and mandibular cortical index (MCI) and the presence of radiographic anomalies suggestive of osteonecrosis were evaluated. RESULTS: There were significant statistical results when comparing the groups in relation to the decrease in bone mineral density (BMD) with MCI-C3 (p = 0.036), however, there were none in relation to MI (p = 0.14). There were no valid statistical results when relating MCI (p = 0.94) and MI (p = 0.66) with reduced BMD and use of bisphosphonates. CONCLUSION: Liver transplant individuals using bisphosphonates present greater radiographic signs of bone sclerosis suggestive of a greater propensity to develop osteonecrosis of the jaw and an increased risk of presenting changes suggestive of reduced bone mineral density on panoramic radiographs when compared to liver transplant individuals not using bisphosphonates.

Medication Non-adherence in Depression: A Systematic Review and Metanalysis.

OBJECTIVE: Medication non-adherence is frequently reported in patients with major depressive disorder (MDD). The objective of this review is to consolidate data on the prevalence of non-adherence to antidepressant in MDD. METHODS: A systematic review with meta-analysis was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline and the protocol was registered in PROSPERO under the number CRD42021199987. Studies assessing medication adherence in MDD were searched in PubMed/Medline, Embase, CINAHL (The Cumulative Index to Nursing and Allied Health Literature) and PsycINFO. The data extraction was performed by two independents authors. Meta-analysis used random effects model and performed a subgroup analysis. RESULTS: From the articles retrieved, eleven studies were considered eligible for the final analysis. Most of them assessed non-adherence by self-report scales, followed by Pharmacy Dispensation Records, Monitoring Events Medication System (MEMS) and blood tests. The pooled proportion of non-adherence was 42% (95% IC 30%-54%), but heterogeneity was very large (I2=99%). CONCLUSION: Data from the selected studies suggests that a high number of individuals with MDD do not adequately take their medication as prescribed. The high heterogenicity of measures used for the assessment of adherence may have impacted the great variability of the results. The results suggest it is necessary that health care professionals should address this issue in order to achieve a better treatment outcome in major depression.

Epigenetic programming for obesity and noncommunicable disease: From womb to tomb.

Several epidemiological, clinical and experimental studies in recent decades have shown the relationship between exposure to stressors during development and health outcomes later in life. The characterization of these susceptible phases, such as preconception, gestation, lactation and adolescence, and the understanding of factors that influence the risk of an adult individual for developing obesity, metabolic and cardiovascular diseases, is the focus of the DOHaD (Developmental Origins of Health and Disease) research line. In this sense, advancements in molecular biology techniques have contributed significantly to the understanding of the mechanisms underlying the observed phenotypes, their morphological and physiological alterations, having as a main driving factor the epigenetic modifications and their consequent modulation of gene expression. The present narrative review aimed to characterize the different susceptible phases of development and associated epigenetic modifications, and their implication in the development of non-communicable diseases. Additionally, we provide useful insights into interventions during development to counteract or prevent long-term programming for disease susceptibility.

Total Protein Intake in Patients with PKU: Adequacy Evaluation According to the European PKU Guidelines from 2017.

In PKU, the protein requirements are contentious. In 2018, we evaluated the protein intake in patients with PKU. Ninety-nine early treated patients aged 19.3 ± 8.2 years (54% males) were studied. A total of 24 had hyperphenylalaninemia (HPA), 48 mild and 27 classical PKU. All had an annual nutritional status evaluation. A total of 83% were on diet therapy only, and 17% were on diet with tetrahydrobiopterin therapy. Anthropometry, metabolic control and nutritional intake [total protein (TP, g/kg), natural protein (NP, g/kg), protein equivalent from protein substitutes (PE, g/kg)] were collected. TP adequacy (TPA) was calculated as a % of WHO (2007) safe levels of protein intake. Results were compared with the European PKU Guidelines (EPG). The median % contribution NP of TP intake was 53% [31-100]. Most patients (78%) had a TP intake above the EPG recommendations. The median TPA was 171% [146-203], with 79% [51-165] from NP and 84% [0-109] from PE. A TPA of 100-140% was observed in 16 (16%) patients. Only n = 6 (6%) patients had a TPA < 100%. These results emphasize the heterogeneity of PKU. More research is needed to understand the necessity of a single protein recommendation for all, as a 'one-size-fits-all' solution might not be appropriate.

Violence, discrimination, and sexual health practices among adolescent men who have sex with men, transgender women and travestis in three cities in Brazil.

The HIV epidemic has a disproportionate impact on adolescent and young men who have sex with men (AMSM) and transgender women and travestis (ATGW), with an increased HIV prevalence over the last 10 years. Violence affects the lives of these populations, undermining their ability to self-care and making them more vulnerable to HIV infection. In this study, we aimed to examine the association between different types of victimization by violence and discrimination and sexual health practices of these adolescent populations in steady and casual relationships. We conducted a cross-sectional study using baseline data from the cohort of PrEP1519 project. We used the mean score of sexual health practices as our outcome and the cumulative score of discrimination (within family, community, education, religious, online and public spaces) and violence (physical, sexual and intimate partner) as our exposure variable. We performed linear regression analyses to estimate the association between exposure and outcome. We found that 90% of AMSM and 95% of ATGW experienced at least one form of violence in the three months prior to this study and about 45% of ATGW suffered sexual violence during the same period. Experiencing discrimination within healthcare settings (from facilities or providers) was negatively associated with sexual health practices. Discrimination and violence negatively affect sexual health practices. HIV prevention and care of AMSM and ATGW people should involve listening to their experiences and addressing discrimination and violence in this population.

Desdobramentos do primeiro vestibular unificado para a identidade profissional da Enfermagem brasileira / Consequences from the first unified entrance exam for the professional identity of Brazilian Nursing / Consecuencias causadas por el primer examen de ingreso unificado para la identidad profesional de la Enfermería Brasileña

Objetivo: descrever o primeiro concurso de vestibular unificado em relação as carreiras biomédicas; analisar os desdobramentos do primeiro concurso de vestibular unificado para a identidade profissional da enfermagem. Método: estudo histórico-social, descritivo, de abordagem qualitativa, que utilizou como fontes 22 publicações sobre o vestibular de 1971 do Jornal dos Sports. Dados foram coletados de julho a setembro de 2021 e analisados pelo referencial de identidade profissional. Resultados: o vestibular unificado permitiu a entrada de 47 homens, pela primeira vez, e 33 mulheres. Majoritariamente não-classificados para medicina, a opção destes candidatos em matricular-se na opção secundária foi uma estratégia de vinculação a uma instituição federal o que atrasou o preenchimento das vagas ociosas e suscitou 11 chamadas reclassificatórias. Conclusão: o vestibular unificado dificultou o acesso ao curso de enfermagem por candidatos convictos da escolha profissional. Admitir candidatos cuja primeira escolha era medicina propiciou a evasão do curso.

Objective: to describe the first unified entrance exam in relation to biomedical careers; analyze the consequences of the first unified entrance exam for nursing professional identity. Method: historical-social, descriptive study, with a qualitative approach, which used as sources 22 publications about the 1971 entrance exam from Jornal dos Sports. Data were collected from July to September/2021 and analyzed using the professional identity framework. Results: The unified entrance exam allowed 47 men to enter, for the first time, and 33 women. Mostly unclassified for medicine, these candidates' choice to enroll in the secondary option was a strategy to link them to a federal institution, which delayed the filling of unfilled vacancies and led to 11 calls for reclassification. Conclusion: the unified entrance exam made it difficult for candidates convinced of their professional choice to access the nursing course. Admitting candidates whose first choice was medicine led to dropouts.

Objetivo: describir el primer examen unificado de ingreso con relación a las carreras biomédicas; analizar las consecuencias del primer examen unificado de ingreso a la universidad respecto a la identidad profesional de enfermería. Método: estudio histórico-social, descriptivo, con enfoque cualitativo, que utilizó como fuentes 22 publicaciones sobre el examen de ingreso de 1971 del Jornal dos Sports. Los datos se recopilaron de julio a septiembre de 2021 y se analizaron utilizando el marco de identidad profesional. Resultados: el examen de ingreso unificado permitió el acceso de 47 hombres, por primera vez, y 33 mujeres. En su mayoría no clasificados para medicina, la elección de estos candidatos de inscribirse en la segunda opción fue una estrategia para vincularse a una institución federal, lo que retrasó la ocupación de vacantes ociosas y generó 11 convocatorias de reclasificación. Conclusión: el examen de ingreso unificado dificultó el acceso a la carrera de enfermería a candidatos convictos de su elección profesional. La admisión de candidatos cuya primera opción era medicina condujo a la deserción del curso.

Cuidados de enfermagem em terapia eletroconvulsiva no período pré-reforma psiquiátrica numa instituição brasileira / Nursing care in electroconvulsive therapy in a Brazilian institution before the Psychiatric Reform / Cuidados de enfermería en la terapia electroconvulsiva en el período prerreforma psiquiátrica en una institución brasileña

Resumo Enquadramento: A terapia electroconvulsiva (TEC) é parte do passado da enfermagem que precisa de ser conhecido, a fim de dar sentido às transformações nos saberes e práticas após a Reforma Psiquiátrica. Objetivo: Identificar os cuidados de enfermagem na aplicação da terapia electroconvulsiva em utentes internados num instituto psiquiátrico brasileiro entre 1980 e 1990. Metodologia: Investigação histórico-social em documentos escritos da instituição cenário e orais produzidos com profissionais de enfermagem, interpretados à luz do referencial foucaultiano. Resultados: Os cuidados de enfermagem foram definidos pela experiência quotidiana e realizados nos momentos pré, trans e pós a aplicação da terapia electroconvulsiva. A enfermagem não tinha formação profissional e agia por conta própria, aplicando a terapia para acalmar utentes agitados ou acompanhando a aplicação pelo médico, prestando cuidados para reduzir efeitos colaterais. Conclusão: Apesar do modelo manicomial, a aplicação da terapia electroconvulsiva contava com cuidados de enfermagem aos utentes para evitar efeitos indesejados. A enfermagem acompanhou o declínio da TEC na sociedade. Este estudo evidenciou características da TEC que não se adequam à prática contemporânea.

Abstract Background: Electroconvulsive therapy (ECT) is a part of Brazilian Nursing History that needs to be known to understand the evolution of knowledge and practice following the Psychiatric Reform. Objective: To identify nursing care for inpatients undergoing ECT at a Brazilian psychiatric institution between 1980 and 1990. Methodology: Social-historical study based on written documents from a Brazilian psychiatric institution and oral statements from nursing professionals, analyzed according to Foucault's framework. Results: Nursing care was defined based on everyday experiences and provided before, during, and after ECT. Nursing professionals had no professional training. They acted autonomously, administering ECT to calm agitated patients, or accompanied physicians' interventions, providing care to reduce the side effects of ECT. Conclusion: Despite being part of the asylum-style care model, ECT included nursing care to avoid unwanted effects. Nursing professionals witnessed the decline of ECT in society. The present study describes aspects of ECT that are inconsistent with today's practice.

Resumen Marco contextual: La terapia electroconvulsiva (TEC) forma parte del pasado de la enfermería que es necesario conocer para dar sentido a las transformaciones del conocimiento y la práctica tras la Reforma Psiquiátrica. Objetivo: Identificar los cuidados de enfermería en la aplicación de la terapia electroconvulsiva en pacientes ingresados en un instituto psiquiátrico brasileño entre 1980 y 1990. Metodología: Investigación histórico-social en documentos escritos de la institución y documentos orales producidos con profesionales de enfermería, interpretados según el referencial foucaultiano. Resultados: Los cuidados de enfermería se definieron por la experiencia diaria y se llevaron a cabo antes, durante y después de la terapia electroconvulsiva. El personal de enfermería no tenía formación profesional y actuaba por su cuenta, aplicando la terapia para calmar a los pacientes agitados o acompañando la aplicación del médico, proporcionando cuidados para reducir los efectos secundarios. Conclusión: A pesar del modelo de manicomio, la aplicación de la terapia electroconvulsiva contaba con cuidados de enfermería a los pacientes para evitar efectos no deseados. La enfermería ha seguido el declive de la TEC en la sociedad. Este estudio pone de manifiesto las características de la TEC que no se ajustan a la práctica contemporánea.

The Health Effects of Low Glycemic Index and Low Glycemic Load Interventions on Prediabetes and Type 2 Diabetes Mellitus: A Literature Review of RCTs.

Diets with a low glycemic index (GI) and a low glycemic load (GL) can improve glycemic control, blood lipids, blood pressure and BMI in prediabetes and type 2 diabetes (T2DM), but evidence regarding other aspects of cardiometabolic health is limited. We searched the literature for RCTs published from 2013 to 2023 and reviewed the evidence on low-GI/GL diets and their effects on different aspects of health in prediabetes and T2DM, aiming to build a report on all relevant outcomes included in the studies. We included 14 RCTs with 1055 participants, who were mostly middle-aged individuals with T2DM. Interventions were mostly low GI and lasted 1-36 months. Low-GI/GL foods and diets showed benefits in terms of short-term glycemic control, weight and adiposity. Longer-term trials would be necessary to determine whether these benefits persist over time and/or lead to lower CVD risk and mortality. Effects on lipid profile were inconsistent. Some studies also reported positive effects of low-GI/GL interventions on blood pressure, inflammatory biomarkers, renal function and gut microbiota composition. Future trials should focus on some of these novel outcome measures, which may provide important insights into the metabolic effects of low-GI diets on individuals with diabetes.

Formação da identidade profissional de enfermeiros para o trabalho no sistema prisional / Development of the professional identity of nurses to work in the prisonal system / Formación de la identidad profesional de los enfermeros para trabajar en el sistema penitenciario

Objetivo:analisar elementos motivadores da construção da identidade profissional de enfermeiros do sistema prisional. Método: estudo histórico-social, qualitativo, sob o método de triangulação de fontes orais e documentais coletados de maio a dezembro de 2020, iluminado pelo referencial foucaultiano. Protocolo de pesquisa aprovado pelo Comitê de Ética e Pesquisa da instituição signatária. Resultados: a realização de concurso público para o sistema prisional foi motivada pela aquisição de estabilidade. Os enfermeiros concursados eram despreparados para cuidar de pessoas presas. A disciplina e os poderes exercidos pelos guardas e presos surpreenderam estes enfermeiros, que precisaram se adaptar ao sistema num contexto social marcado pela violência urbana. Considerações finais: destaca-se, na construção da identidade destes profissionais, a capacidade para contornar medos e inseguranças, exercício de poder disciplinar e normatização do cuidado para o enfrentamento do cotidiano do trabalho. Emerge a necessidade de capacitação de enfermeiros nesta área na formação profissional.

Objective: to analyze elements that motivate the construction of the professional identity of nurses in the prison system. Method: historical-social, qualitative study, under the method of triangulation of oral and documental sources collected from May to December 2020, illuminated by the Foucaultian reference. Approved by the Ethics and Research Committee. Results: the holding of a public tender for the prison system was motivated by the acquisition of stability. The registered nurses were unprepared to take care of prisoners. The discipline and powers exercised by guards and prisoners surprised these nurses, who had to adapt to the system in a social context marked by urban violence. Final considerations: in the construction of the identity of these professionals, the ability to overcome fears and insecurities, exercising disciplinary Power and standardizing care for coping with daily work is highlighted. The need to train nurses in thisarea in professional training emerges.

Objetivo: analizar elementos que motivan la construcción de la identidad profesional de las enfermeras en el sistema penitenciario. Método: estudio histórico-social, cualitativo, iluminado por el referente foucaultiano, que utiliza el método de triangulación de fuentes orales y documentales recolectadas de mayo a 20 de diciembre. El Comité de Ética en Investigación de la institución firmante aprobó el protocolo de investigación. Resultados: la realización de un concurso público para el sistema penitenciario estuvo motivada por la adquisición de estabilidad. Los enfermeros aprobados por ese concurso público no estaban preparados para cuidar a los presos. La disciplina y los poderes que ejercían los guardias y presos sorprendieron a estos enfermeros, que debieron adaptarse al sistema en un contexto social marcado por la violencia urbana. Consideraciones finales: en la construcción de la identidad de estos profesionales se destaca la capacidad de superación de miedos e inseguridades, ejercicio de poder disciplinario y estandarización de los cuidados para hacer frente al cotidiano del trabajo. Surge la necesidad de capacitar a enfermeros en esta área en la formación profesional.

Gender diversity and syphilis: something's going on?

Introduction: This study aims to analyze the influence of syphilis among people with sexual and gender diversity, different from the binary dimension. Materials and methods: A systematic review was conducted as a method to address the objective of the study, based on the Dialectical Structural Model of Care (DSM), to obtain the phenomenon from the perspective of cultural history. Results: In this review the analysis of 129 documents, of which 22 texts were used. The construction of sex and gender in Western civilization is based on the Judeo-Christian tradition, which permitted many people throughout history to be persecuted and mistreated for living a lifestyle different from that dictated by religious and traditional canons. Therefore, throughout history, gender-diverse people, sexual minorities, and prostitutes have suffered segregation, mockery, aggression, and health problems, including syphilis. Conclusions: Despite having a treatment and cure, syphilis has stood the test of time and has remained a secret pathology that is obscure and difficult to detect disease, which is still very much present in people of all social classes. It is necessary to review history to understand the reasons why syphilis is still prevalent in different societies today.

Telehealth effectiveness for pre-exposure prophylaxis delivery in Brazilian public services: the Combine! Study.

INTRODUCTION: Pre-exposure prophylaxis (PrEP) delivery based on user needs can enhance PrEP access and impact. We examined whether telehealth for daily oral PrEP delivery could change the indicators of care related to prophylactic use in five Brazilian public HIV clinics (testing centres, outpatient clinics and infectious disease hospitals). METHODS: Between July 2019 and December 2020, clients on PrEP for at least 6 months could transition to telehealth or stay with in-person follow-up. Clients were clinically monitored until June 2021. A desktop or mobile application was developed, comprising three asynchronous consultations and one annual in-person consultation visit. Predictors influencing telehealth preference and care outcomes were examined. The analysis encompassed intent-to-treat (first choice) and adjustments for sexual practices, schooling, age, duration of PrEP use and PrEP status during the choice period. RESULTS: Of 470 users, 52% chose telehealth, with the adjusted odds ratio (aOR) increasing over time for PrEP use (aOR for 25-months of use: 4.90; 95% CI: 1.32-18.25), having discontinued PrEP at the time of the choice (aOR: 2.91; 95% CI: 1.40-6.06) and having health insurance (aOR: 1.91; 95% CI: 1.24-2.94) and decreasing for those who reported higher-risk behaviour (aOR for unprotected anal sex: 0.51; 95% CI: 0.29-0.88). After an average follow-up period of 1.6 years (95% CI: 1.5-1.7), the risk of discontinuing PrEP (not having the medication for more than 90 days) was 34% lower with telehealth (adjusted hazard ratio: 0.66; 95% CI: 0.45-0.97). When adjusted by mixed linear regression, no differences in adherence (measured by mean medication possession rate) were found between in-person and telehealth (p = 0.486) or at pre- and post-telehealth follow-ups (p = 0.245). Sexually transmitted infections increased between the pre-follow-up and post-follow-up choices and were not associated with in-person or telehealth (p = 0.528). No HIV infections were observed. CONCLUSIONS: Our findings indicate that telehealth for PrEP delivery can enhance service rationalization and reinforce the prevention cascade. This approach reduces prophylaxis interruptions and is mainly preferred by individuals with lower demands for healthcare services.

HBM4EU-MOM: Prenatal methylmercury-exposure control in five countries through suitable dietary advice for pregnancy - Study design and characteristics of participants.

BACKGROUND: Seafood is a major source of vital nutrients for optimal fetal growth, but at the same time is the main source of exposure to methylmercury (MeHg), an established neurodevelopmental toxicant. Pregnant women must be provided with dietary advice so as to include safely fish in their diet for nutrition and mercury control. The aim of this work is to present the design of a multicentre randomized control trial (RCT), which combines human biomonitoring (HBM) with dietary interventions using seafood consumption advice to pregnant women for MeHg control, and to collect information about other possible sources of exposure to mercury. It also presents the materials developed for the implementation of the study and the characteristics of the study participants, which were self-reported in the first trimester of pregnancy. METHODS: The "HBM4EU-MOM" RCT was performed in the frame of the European Human Biomonitoring Initiative (HBM4EU) in five coastal, high fish-consuming European countries (Cyprus, Greece, Spain, Portugal and Iceland). According to the study design, pregnant women (≥120/country, ≤20 weeks gestational age) provided a hair sample for total mercury assessment (THg) and personal information relevant to the study (e.g., lifestyle, pregnancy status, diet before and during the pregnancy, information on seafood and factors related to possible non-dietary exposures to mercury) during the first trimester of pregnancy. After sampling, participants were randomly assigned to "control" (habitual practices) or "intervention" (received the harmonized HBM4EU-MOM dietary advice for fish consumption during the pregnancy and were encouraged to follow it). Around child delivery, participants provided a second hair sample and completed another tailored questionnaire. RESULTS: A total of 654 women aged 18-45 years were recruited in 2021 in the five countries, primarily through their health-care providers. The pre-pregnancy BMI of the participants ranged from underweight to obese, but was on average within the healthy range. For 73% of the women, the pregnancy was planned. 26% of the women were active smokers before the pregnancy and 8% continued to smoke during the pregnancy, while 33% were passive smokers before pregnancy and 23% remained passively exposed during the pregnancy. 53% of the women self-reported making dietary changes for their pregnancy, with 74% of these women reporting making the changes upon learning of their pregnancy. Of the 43% who did not change their diet for the pregnancy, 74% reported that their diet was already balanced, 6% found it difficult to make changes and 2% were unsure of what changes to make. Seafood consumption did not change significantly before and during the first trimester of pregnancy (overall average ∼8 times per month), with the highest frequency reported in Portugal (≥15 times per month), followed by Spain (≥7 times per month). During the first-trimester of pregnancy, 89% of the Portuguese women, 85% of the Spanish women and <50% of Greek, Cypriot and Icelandic women reported that they had consumed big oily fish. Relevant to non-dietary exposure sources, most participants (>90%) were unaware of safe procedures for handling spillage from broken thermometers and energy-saving lamps, though >22% experienced such an incident (>1 year ago). 26% of the women had dental amalgams. ∼1% had amalgams placed and ∼2% had amalgams removed during peri-pregnancy. 28% had their hair dyed in the past 3 months and 40% had body tattoos. 8% engaged with gardening involving fertilizers/pesticides and 19% with hobbies involving paints/pigments/dyes. CONCLUSIONS: The study design materials were fit for the purposes of harmonization and quality-assurance. The harmonized information collected from pregnant women suggests that it is important to raise the awareness of women of reproductive age and pregnant women about how to safely include fish in their diet and to empower them to make proper decisions for nutrition and control of MeHg, as well as other chemical exposures.

Professional identity of nurses in pandemic times: new/old challenges reproduced in news media.

OBJECTIVE: To analyze aspects related to the professional identity of nurses during the COVID-19 pandemic usingnews media as a source. METHOD: Qualitative, and retrospective document study with 51 reports from Folha de São Paulo from March to December 2020. Data was organized using ATLAS.ti, with Thematic Content Analysis and discussion from the theoretical perspective of Claude Dubar. RESULTS: Three categories were formed: Identity captured by the images reflected on the text; The identity symbolized by the support of nurses to those who need care; and The identity symbolized by the support of nurses to those who need care. CONCLUSION: Despite the fact that the image of nurses is still mistakenly apprehended, the way they provide care, their commitment to the population, and their scientific mindedness ensured visibility and enabled a more empowered and secure identity for their role in society.

Relationship between polyvictimization and overweight among adolescents from São Paulo city, Brazil.

This study is to identify victimization patterns and analyze the association between the experience of polyvictimization and overweight or obesity among adolescent girls and boys. The sample consisted of 2680 Brazilian ninth-graders enrolled in public and private schools, taken from the São Paulo Project for the social development of children and adolescents (SP-PROSO). Victimization was explored in two ways: (i) as per Finkelhor and (ii) by latent class analysis (LCA). The interest outcomes were overweight and obesity. Multinomial logistic regression models were used to study the relationship between victimization and overweight or obesity, controlling for confounders. LCA grouped boys and girls adolescents into three classes. These classes received the same labels, but the patterns differed between sexes. Class 1 was characterized by fewer types of victimization suffered and lower endorsement values in the analyzed items and was named bullying and indirect victimization (♀: 42.7%, n = 546; ♂: 21.6%, n = 293). Class 2 included more victimization types than Class 1 and less than Class 3. This class was labeled family violence and peer victimization (♀: 29.1%, n = 356; ♂: 47.9%, n = 652). Class 3 was named high polyvictimization (♀: 28.2%, n = 345; ♂: 30.5%, n = 418). According to Finkelhor, polyvictimization was not associated with overweight or obesity in both sexes. Only the class of high polyvictimization was associated with being overweight (ORadj: 1.60, 95%CI: 1.01-2.54) in girls. In this study, polyvictimization was associated with being overweight only among adolescent girls. Longitudinal studies in different contexts and populations are needed to understand this relationship.

Organizational politics and professional struggles in nursing.

OBJECTIVE: to analyze the professional struggles between nursing organizational entities, in Rio de Janeiro, during the Regional Nursing Council's electoral process (1990-1993 administration). METHOD: historical study. We used journalistic articles, normative documents, legislation and semi-structured interviews with five nursing professionals who participated in this process. Interpretation of findings was supported by Bourdieu's concepts of habitus, field, capital, and symbolic power. RESULTS: Electoral Code changes of the aforementioned council, under the influence of administration (1987-1990), candidate for re-election, influenced the disclosure and eligibility criteria, making it difficult for broad participation, especially of Associação Brasileira de Enfermagem Rio de Janeiro Section. FINAL CONSIDERATIONS: nursing, in this period, generated a field of disputes related to positions of power and gender, which was evidenced in the electoral process studied, which highlighted using limiting strategies by a group, making it difficult for the entire category to participate.

Fátima Sampaio: vida e trajetória profissional como marcos da história da enfermagem / Fátima Sampaio: life and professional history as marks in the history of nursing / Fátima Sampaio: vida e historia profesional como marcas en la historia de la enfermería

Objetivo: descrever a trajetória profissional da piauiense Maria do Rozário de Fátima Borges Sampaio no ensino, na gestão e nos Conselhos Federal e Regional de Enfermagem. Métodos: estudo de natureza histórico-biográfica, embasado na metodologia da história oral de vida, cuja construção foi fundamentada em fontes orais, entrevista semiestruturada; e escritas, como atas, resoluções e comunicados disponibilizados pelo Conselho Federal de Enfermagem e Conselho Regional de Enfermagem ­ seção Piauí. A análise dos dados ocorreu para articular as informações captadas nas fontes para se construir a narrativa histórica. Resultados: Foram apresentados em dois quadros, que deram origem a três categorias discursivas: Vida e formação ­ de menina do interior à mestre; Ensino e gestão ­ todo enfermeiro é um educador e um gestor; Entidades de classe ­ representação da enfermagem e do Piauí. Conclusão: a história de Maria do Rozário de Fátima Borges Sampaio mostra uma mulher determinada e compromissada com a profissão, forte para enfrentar desafios, sensível no trato com o paciente e a complexidade deste, questionadora, estudiosa, dedicada e ética nas decisões, tanto no que se refere à assistência de enfermagem quanto às deliberações voltadas aos órgãos dos quais participou e presidiu. (AU)

Objective: to describe the professional trajectory of Maria do Rozário de Fátima Borges Sampaio, from Piauí, in teaching, management and in the Federal and Regional Councils of Nursing. Methods: a historical-biographical study, based on the methodology of oral history of life, whose construction was based on oral sources, semi-structured interviews, and written sources, such as minutes, resolutions, and communications made available by the Federal Council of Nursing and the Regional Council of Nursing - Piauí section. Data analysis occurred to articulate the information captured in the sources to build the historical narrative. Results: They were presented in two tables, which gave rise to three discursive categories: Life and training - from countryside girl to master; Teaching and management - every nurse is an educator and a manager; Class entities - representation of nursing and Piauí. Conclusion: the history of Maria do Rozário de Fátima Borges Sampaio shows a woman determined and committed to the profession, strong to face challenges, sensitive in dealing with patients and their complexity, questioning, studious, dedicated and ethical in her decisions, both in terms of nursing care and in terms of the deliberations focused on the bodies of which she participated and presided. (AU)

Objetivo: describir la trayectoria profesional de Maria do Rozário de Fátima Borges Sampaio, de Piauí, en la docencia, la gestión y en los Consejos Federal y Regional de Enfermería. Métodos: estudio de naturaleza histórico-biográfica, basado en la metodología de la historia oral de la vida, cuya construcción se fundamenta en fuentes orales, entrevistas semiestructuradas; y escritas, como atas, resoluciones y comunicados disponibles por el Consejo Federal de Enfermería y el Consejo Regional de Enfermería - sede Piauí. El análisis de los datos se produjo para articular la información captada en las fuentes para construir el relato histórico. Resultados: Se presentaron en dos cuadros, que dieron lugar a tres categorías discursivas: Vida y formación - de campesina a maestra; Enseñanza y gestión - toda enfermera es educadora y gestora; Entidades de clase - representación de la enfermería y de Piauí. Conclusión: la historia de Maria do Rozário de Fátima Borges Sampaio muestra a una mujer decidida y comprometida con la profesión, fuerte para afrontar los retos, sensible en el trato con los pacientes y su complejidad, cuestionadora, estudiosa, dedicada y ética en sus decisiones, tanto en lo que se refiere a los cuidados de enfermería como a las deliberaciones centradas en los órganos de los que participó y presidió. (AU)

Trajetória e participação política da enfermagem em Santa Catarina no período 1972-2018 / Trajectory and political participation of nursing in Santa Catarina in the period 1972-2018 / Trayectoria y participación política de la enfermería em Santa Catarina em el período 1972-2018

Objetivo: conhecer a participação política dos profissionais da enfermagem enquanto reflexo de suas entidades representativas. Métodos: pesquisa qualitativa de abordagem histórico-social. Dentro do recorte histórico de 1972 a 2018, entre março e setembro de 2019, entrevistaram-se 5 ex-presidentes das Associação Brasileira de Enfermagem - Seção Santa Catarina e do Conselho Regional de Enfermagem de Santa Catarina. A compreensão dos dados se deu por meio da análise de conteúdo de Bardin e interpretação através do marco conceitual de Denise Elvira Pires de Pires. Resultados: percebe-se uma significativa mudança de quadro da participação política da enfermagem através das décadas. Desde a criação da ABEn-SC a enfermagem transita de um corpo forte e unido para uma trajetória e participação em subsequente desarticulação. Conclusão: A desmobilização de uma categoria é multifatorial. Reflexo da desarticulação das entidades representativas da profissão, raízes histórico-culturais de sua fundação e do imaginário individual e social de uma profissão. (AU)

Objective: To Know the political participation of nursing professionals as a reflection of their representative entities. Methods: qualitative research of a historical-social nature in the history of 1975 to 2018, between March and September 2019. Interviewed 5 former presidents of the Brazilian Nursing Association - Santa Catarina Section and the Regional Nursing Council of Santa Catarina. The understanding of the data took place through the analysis of Bardin's content and interpretation through the conceptual framework of Denise Elvira Pires de Pires, profession, discipline and work. Results: there is a significant change in the framework of political participation in nursing over the decades. With a fragile articulation between the entities representing the category. Conclusion: The demobilization of the professional category is multifactorial. Reflection of the disarticulation of the entities representing the profession, the historical and cultural roots of its foundation and the individual and social imagery of the profession. (AU)

Objetivo: conocer la participación política de los profesionales de enfermería como reflejo de sus entidades representativas. Métodos: investigación cualitativa de carácter histórico-social en la historia de 1975 a 2018, entre marzo y septiembre de 2019. Se entrevistó a 5 ex presidentes de la Asociación Brasileña de Enfermería - Sección Santa Catarina y el Consejo Regional de Enfermería de Santa Catarina. La comprensión de los datos se llevó a cabo a través del análisis del contenido y la interpretación de Bardin a través del marco conceptual de Denise Elvira Pires de Pires, profesión, disciplina y trabajo. Resultados: hay un cambio significativo en el marco de participación política en enfermería a lo largo de las décadas. Con una articulación frágil entre las entidades que representan la categoría. Conclusión: La desmovilización de la categoría profesional es multifactorial. Reflejo de la desarticulación de los entes representativos de la profesión, las raíces históricas y culturales de su fundación y el imaginario individual y social de la profesión. (AU)

COVID-19: Understanding the impact of anti-hypertensive drugs and hydroxychloroquine on the ACE1 and ACE2 in lung and adipose tissue in SHR and WKY rats.

Hypertensive individuals taking anti-hypertensive drugs from renin-angiotensin system inhibitors may exhibit a more severe evolution of the disease when contracting the SARS-CoV-2 virus (COVID-19 disease) due to potential increases in ACE2 expression. The study investigated ACE1 and ACE2 axes and hydroxychloroquine in the lungs and adipose tissue of male and female normotensive Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHRs). SHRs were treated with losartan (10 mg/kg/day) or captopril (10 mg/kg/day) for 14 days or 7 days with hydroxychloroquine (200 mg/kg/day) in drinking water. WKY rats were also treated for 7 days with hydroxychloroquine. Blood pressure (BP), protein, and mRNA expression of ACE1 and ACE2 were analyzed in serum, adipose, and lung tissues. Losartan and captopril reduced BP in both sexes in SHR, whereas hydroxychloroquine increased BP in WKY rats. Losartan reduced ACE2 in serum and lungs in both sexes and in adipose tissue of male SHRs. Captopril decreased ACE2 protein in the lung of females and in adipose tissue in both sexes of SHRs. Hydroxychloroquine decreased ACE1 and ACE2 proteins in the lungs in both sexes and adipose tissue in male SHRs. In female WKY rats, ACE2 protein was lower only in the lungs and adipose tissue. Losartan effectively inhibited ACE2 in male and captopril in female SHRs. Hydroxychloroquine inhibited ACE2 in male SHRs and female WKY rats. These results further our understanding of the ACE2 mechanism in patients under renin-angiotensin anti-hypertensive therapy and in many trials using hydroxychloroquine for COVID-19 treatment and potential sex differences in response to drug treatment.

Experiência de uma capacitação virtual durante à COVID-19: Fortalecimento do ensino da história da Enfermagem / Experience of virtual training during covid-19: strengthening the teaching of nursing history / Experiencia sobre una formación virtual durante la covid-19: reforzar la enseñanza de la historia de la enfermería

Objetivo: relatar as experiências obtidas com a Capacitação Virtual em História da Enfermagem no período de distanciamento social da pandemia da COVID-19. Método: relato de experiência da construção e execução de uma Capacitação por meio de mídia virtual, desenvolvida no ano de 2020, em uma parceria entre ações extensionistas dos museus das Escolas de Enfermagem de Universidades Públicas Federais/Brasil, com apoio da Associação Brasileira de Enfermagem. As experiências foram discutidas nos campos da História da Enfermagem e da Educação. Resultados: com um total de 132 inscritos, a Capacitação foi realizada por meio de quatro transmissões ao vivo através do Instagram. A utilização de lives de acesso livre ao público possibilitou alcançar em média 358 pessoas. Os formulários elaborados e distribuídos aos inscritos subsidiaram a estruturação dos conteúdos abordados durante os encontros, a criação de metodologias ativas disponibilizadas aos participantes para apoiar o ensino de História da Enfermagem e também a avaliação final da Capacitação. Conclusão: a Capacitação permitiu contornar as dificuldades impostas pelo distanciamento social e contribuiu para dar protagonismo aos envolvidos, constituindo uma rede de apoio ao ensino de História da Enfermagem.(AU)

Objective: to report the experiences obtained in the Virtual Training in Nursing History in the period of social distancing resulting from the COVID-19 pandemic. Method: experience report on the construction and implementation of training through virtual media, carried out in the year 2020 in a partnership between extensionist actions of the museums of the Schools of Nursing of federal public universities in Brazil, with the support of the Brazilian Association of Nursing Section Minas Gerais (ABEn). In the experiences, the fields of History of Nursing and Education were discussed. Results: with a total of 132 subscribers, the Training was carried out through four live broadcasts on Instagram. The use of lives with free access to the public made it possible to reach, on average, 358 people. The forms prepared and distributed to those enrolled supported the following steps: structuring the content addressed during the meetings; the creation of active methodologies available to participants to support the teaching of History of Nursing; and the final evaluation of the Training. Conclusion: training made it possible to overcome the difficulties imposed by social distancing and contributed to giving prominence to those involved, constituting a support network in the teaching of Nursing History.(AU)

Objetivo: contar las experiencias de la Formación Virtual en Historia de la Enfermería en el período de distanciamiento social de la pandemia del COVID-19. Método: relato de cómo fue la experiencia de la creación y ejecución de una Formación a través de medios virtuales, desarrollada en el año 2020, en una alianza entre acciones extensionistas de los museos de las Escuelas de Enfermería de las Universidades Públicas Federales/Brasil, con apoyo de la Asociación Brasileña de Enfermería. Las experiencias fueron discutidas en los campos de Historia de la Enfermería y de la Educación. Resultados: con un total de 132 inscritos, la Formación se llevó a cabo mediante cuatro transmisiones en directo a través de Instagram. El uso de ''en directos" de libre acceso al público permitió llegar a una media de 358 personas. Los formularios elaborados y distribuidos a los participantes apoyaron la estructuración de los contenidos abordados durante los encuentros, la creación de metodologías activas a disposición de los participantes para apoyar la enseñanza dela Historia de la Enfermería y también la evaluación final de la Formación. Conclusión: la Formación permitió superar las dificultades impuestas por el distanciamiento social y contribuyó a dar protagonismo a los implicados, constituyendo una red de apoyo a la enseñanza de la Historia de la Enfermería.(AU)