Evaluation of Biodistribution of Functionalized Magnetic Core/Carbon-Shell Nanoparticles in Systemic Method of Administration.

We studied new magnetic nanocomposites consisting of a core(Fe) and carbon-shell inert to biological media. Iron-carbon nanoparticles circulate in the bloodstream for several minutes and are primarily accumulated in the liver; less intensive accumulation was found in the spleen and minimum in the lungs, kidneys, and heart. Accumulation of nanoparticles in the liver leads to the development of destructive processes and is accompanied by activation of compensatory-adaptive mechanisms. In the liver and spleen, structural changes are mild and mainly relate to changes in the microvasculature. In 6 months, the total content of nanoparticles in all tissues decreased due to their elimination from the body and the structure of the organs returned to normal.

[Development, structure and myeloarchitectonics of the intraorganic nerves of the human hand muscles in infancy and childhood]. / Razvitie, stroenie i mieloarkhitektonika intraorgannykh nervov myshts kisti cheloveka v period rannego i pervogo detstva.

Twenty-two corpses of children (1-6 years of age) have been investigated. During the first year of life, certain manifested morphological changes take place in the innervation apparatus of the child hand muscles. The nerves are intensively growing in length, surpassing the muscles growth. With the development, some changes of the myelin transmitters spectrum occur: the number of fibers with large and middle diameter increases. This process is subjected to essential individual variations. Besides myelinization, the total number of fibers in the nerves increases, as well. By 6 years of age, the conductive part of the neural apparatus of the muscles studied reaches a rather high developmental level. The content of thick fibers in the toe muscle nerves makes more than 40%, the part of the middle fibers is also high. The muscles in the little finger mound leg behind in development of their nerves, the middle fibers prevail in them. Asynchronism in development is peculiar for nerves in some separate muscles. The correlation revealed for the main components of the neural fiber demonstrates that it is optimal in the toe muscle nerves. The little finger muscle nerves reach a high level of development, but the main mass of their fibers is still at the stage of maturing.

[Micromorphology of the intraorganic nerves of the hand muscles in human fetuses of the 2d half of the prenatal development and in children up to 1 year of age]. / Mikromorfologiia intraorgannykh nervov myshts kisti u plodov cheloveka vtoroi poloviny prenatal'nogo razvitiia i u detei do goda.

The intraorganic nerves of the fetus hand muscles in the second half of the prenatal development (beginning from the 4.5th month of the intrauterine development) have a conductive part in the nerve system with certain signs of immaturity: weak branching of the neural trunks, abundant perineural cells, great amount of the intratrunkal plexuses, various forms of the neural fibre transversal section. By the time of birth, in the fetal neural trunclets fine fibres predominate, percent of the middle one increases. After birth, general architectonics of the intraorganic nerves remain the same. During the first year of life, the amount of the intramuscular nerves and their branchings increases, the neural fibres acquire a more regulated course, the intratruncal plexuses become less pronounced. In the neural faciculi, percent of the middle fibres increases essentially, the thick ones appear. By the first year of life, a considerable difference in the intratruncal structure of the intraorganic nerves in the eminence muscle of the thumb and the little finger becomes evident.