RESUMO
THE PURPOSE: To study effect of controllable moderate hypothermia on system of hemostasis in newborns with hypoxemic ischemic encephalopathy. MATERIALS AND METHODS: The retrospective analysis was carried out concerning 38 medical records of newborns with acute hypoxia of fetus (group I), 12 medical records of newborns with acute hypoxia of fetus against the background of chronic hypoxia of fetus (group II), 20 healthy newborns (group III) and 20 healthy adults. The thromboelastography was implemented in three stages: at first, third and sixth days of life of newborns. CONCLUSION: The thromboelastography is to be implemented in newborns with hypoxemic ischemic encephalopathy due to occurrence of of hemostasis shifting to hypocoagulation and high risk of bleeding. In healthy full-term children a physiological hypercoagulation was established as compared with adults without alterations of processes of lysis of clots. In newborns with chronic hypoxia of fetus against the background of applied medical hypothermia, in comparison with healthy newborns, decreasing of number of thrombocytes are observed and possibly lower functional activity of thrombocytes up to third day and also lower activity of plasma component of hemostasis at retained elasticity and strength of developed clots. The sixth day, after heating, the system of hemostasis is normalized and number of thrombocytes is restored. In newborns, having acute hypoxia of fetus against the background of chronic hypoxia of fetus higher risk of bleeding is noted at minimal difference according results of thromboelastography.
RESUMO
A comparative estimation was conducted to assess the prevalence of genotypes and alleles of the (353)R>Q polymorphism of the coagulation factor FVII gene between a group of the Russian adolescents with essential arterial hypertension and a group of Russian adolescents without such health problems. The RR genotype was diagnosed in 55 adolescents (75.34%) of the control group and in 99 adolescents (84.61%) of the adolescents suffering from essential arterial hypertension (χ2 = 1.949, p = 0.163). The frequency of the R-allel was 85% and 91.9%, respectively (χ2 = 3.110, p = 0.078). The role of the FVII gene in the determination of the F7 plasma activity was defined in adolescents with essential arterial hypertension and holders of different alleles. Holders of the R allele had significantly higher activity of coagulation factor F7 (97.66 ± 15.48 against 83.37 ± 15.16, p = 0.002) and factor F2 (107.45 ± 6.03 against 103.75 ± 6.81, p = 0.023) than holders of the Q allele. This relationship was not found in adolescents of the control group.