RESUMO
Scrub typhus in Bhutan was first reported in 2009. We investigated an outbreak of scrub typhus in a remote primary school during August-October 2014. Delay in recognition and treatment resulted in 2 deaths from meningoencephalitis. Scrub typhus warrants urgent public health interventions in Bhutan.
Assuntos
Surtos de Doenças , Instituições Acadêmicas , Tifo por Ácaros/epidemiologia , Butão/epidemiologia , Criança , Feminino , História do Século XXI , Humanos , Imunoglobulina G/imunologia , Imunoglobulina M/imunologia , Orientia tsutsugamushi/imunologia , Vigilância da População , Tifo por Ácaros/história , Tifo por Ácaros/imunologiaRESUMO
Dengue is one of the most significant public health problems in tropical and subtropical countries, and is increasingly being detected in traditionally non-endemic areas. In Bhutan, dengue virus (DENV) has only recently been detected and limited information is available. In this study, we analyzed the epidemiological and molecular characteristics of DENV in two southern districts in Bhutan from 2013-2014. During this period, 379 patients were clinically diagnosed with suspected dengue, of whom 119 (31.4%) were positive for DENV infection by NS1 ELISA and/or nested RT-PCR. DENV serotypes 1, 2 and 3 were detected with DENV-1 being predominant. Phylogenetic analysis of DENV-1 using envelope gene demonstrated genotype V, closely related to strains from northern India.