Stemming the Leak: A Novel Treatment for Gastro-Bronchial Fistula.

Laparoscopic sleeve gastrectomy (LSG) is a commonly used procedure in bariatric patients that often has excellent results. Despite its advantages, LSG is burdened by specific intraoperative and postoperative early and late complications. One of the life-threatening complications is gastric fistula, usually treated with a multidisciplinary surgical-endoscopic approach. In case of failure of the latter, alternative nonoperative techniques such as the use of autologous stem cells truly represents an innovative possibility, with only few cases described in literature. Here, we report the case of a 25-year-old man with post-LSG broncho-gastric fistula treated with application of autologous stem cells after the failure of the conventional surgical/endoscopic approach.

O domicílio como cenário alternativo de apoio ao paciente oncológico / Households as an alternative support scenario for cancer patients / El domicilio como escenario alternativo de apoyo al paciente oncológico

Trata-se de um artigo de reflexão sobre a assistência domiciliar a pacientes oncológicos e sua importância, tendo em vista o crescente aumento do número de internações por neoplasias e a diminuição da qualidade de vida dessa clientela, quando mantida em instituições de saúde por longo tempo. As autoras discutem a relevância da atuação da família junto ao paciente no domicílio e dos profissionais de saúde junto a ambos, no cenário domiciliar, como relevante estratégia alternativa e peculiar de suporte e de cuidados que abrangem o nível psicossocial da pessoa que vivencia o câncer. Apresentam também alguns aspectos da evolução histórica da assistência domiciliar e hospitalar, as modalidades de atendimento de portadores de câncer em domicílio e pontuam como vantagens deste: a humanização no cuidado e no tratamento de saúde, a diminuição de internações hospitalares bem como de ocorrências de infecções e redução do tempo de permanência hospitalar, a satisfação do paciente e seus familiares, além da redução de custos.

This study offers a reflection about the importance of home care for cancer patients, given the increasing number of hospital admittances due to malignant diseases and the reduced quality of life of these patients when kept in health institutions for prolonged periods. The authors discuss the relevance of family support for patients within their homes and the support given by health professionals to patients and family members in this context. This is emphasized as a relevant and specific alternative support and care strategy that includes the psychosocial domains of persons experiencing cancer. The authors also describe the history of hospital and home care and the type of care for cancer patients at home, underlining the advantages of home care, which include humanized health care and treatment, reduction of the number of hospital admittances, lower infection rates, reduced hospital stay, patient and family satisfaction, and cost reduction.

Se trata de un artículo de reflexión sobre la atención domiciliaria a pacientes oncológicos y su importancia, considerando el aumento de número de internaciones por neoplasias y la disminución de calidad de vida de dichos pacientes cuando permanecen en instituciones de salud durante mucho tiempo. Las autoras discuten la importancia de la actuación de la familia junto al paciente en el domicilio y de los profesionales de salud junto a ambos, en el escenario domiciliario, como estrategia alternativa, importante y peculiar de soporte y de cuidados que incluyen el nivel psicosocial de la persona que sufre de cáncer. También presentan algunos aspectos de la evolución histórica de la atención domiciliaria y hospitalaria, las modalidades de atención domiciliaria a portadores de cáncer y entre sus ventajas mencionan: humanización en el cuidado y tratamiento de salud, disminución de internaciones hospitalarias y también de ocurrencia de infecciones y reducción del tiempo de permanencia en el hospital, satisfacción del paciente y sus familiares, además de reducción de costos.

Erythrocyte-mediated delivery of dexamethasone in patients with chronic obstructive pulmonary disease.

Human erythrocytes from ten patients with chronic obstructive pulmonary disease (COPD) were loaded with increasing amounts of dexamethasone 21-phosphate and were re-infused into the original donors. Drug-loaded erythrocytes acted as circulating bioreactors, converting the non-diffusible dexamethasone 21-phosphate into the diffusible dexamethasone. Pharmacokinetic analyses on these patients showed that a single administration of drug-loaded erythrocytes was able to maintain detectable dexamethasone concentrations in blood for up to seven days. This continuous release of dexamethasone was paralleled by the suspension of beta2-agonist and oral corticosteroid treatments by all of the patients. Thus dexamethasone 21-phosphate-loaded erythrocytes are safe carriers for corticosteroid analogues and are a useful alternative to frequent oral or inhaled drugs in elderly patients with COPD.