RESUMO
OBJECTIVES: Induction chemotherapy (IC) followed by chemoradiation (CRT) for locally advanced squamous cell head and neck cancer (SCCHN) remains controversial in the absence of clear evidence to define its role. As part of a prospective, randomised, multicentre study of CRT for stage III/IV laryngeal/hypopharyngeal cancers (ART DECO, CRUK/10/018), we have examined the attitudes of oncologists in the United Kingdom (UK) to IC. MATERIALS AND METHODS: Head and neck oncologists across the UK who expressed an interest in participating in the ART DECO trial were asked to complete a short written questionnaire designed to identify current UK practice of IC for stage III-IVb SCCHN. Completed questionnaires were returned to the clinical trials office prior to patient recruitment. RESULTS: Clinicians from twenty-five/48 centres (52.1%) responded. Twenty centres (80%) elected to use IC in the trial. For stage III disease, 80% of centres did not prescribe IC for T1N1 disease and 60% did not offer IC for T3N0 disease. Patients with bulky primary tumours or extensive nodal disease were more likely to receive IC. Thirteen prescribing centres (65%) use 3 drugs (docetaxel, cisplatin, and 5-fluorouracil) compared to 7 (35%) using 2 drugs (cisplatin and 5-fluorouracil). Fifteen centres (75%) prescribed 2 cycles of IC, and 5 (25%) prescribed 3 cycles. There was variation in the dosage for both the 2- and 3-drug regimens. CONCLUSION: Results suggest that clinical practice in the UK is currently divided between a 2- versus 3-drug regimen for IC for specific subgroups of patients. A consensus regarding the optimal combinations and dosages is required before further optimization of systemic therapy with other cytotoxics and biological agents is attempted.
Assuntos
Atitude do Pessoal de Saúde , Neoplasias Hipofaríngeas/tratamento farmacológico , Quimioterapia de Indução/estatística & dados numéricos , Neoplasias Laríngeas/tratamento farmacológico , Oncologia/métodos , Humanos , Reino UnidoAssuntos
Doenças dos Bovinos/microbiologia , Chlamydophila psittaci/isolamento & purificação , Encefalite/veterinária , Psitacose/veterinária , Animais , Animais Recém-Nascidos , Encéfalo/microbiologia , Encéfalo/patologia , Bovinos , Doenças dos Bovinos/diagnóstico , Doenças dos Bovinos/patologia , Chlamydophila psittaci/genética , DNA Bacteriano/análise , Diagnóstico Diferencial , Encefalite/microbiologia , Encefalite/patologia , Masculino , Psitacose/patologiaAssuntos
Intoxicação por Plantas/veterinária , Plantas Tóxicas , Doenças dos Ovinos/etiologia , Anemia Hemolítica/etiologia , Anemia Hemolítica/veterinária , Criação de Animais Domésticos , Animais , Hematúria/etiologia , Hematúria/veterinária , Intoxicação por Plantas/etiologia , Intoxicação por Plantas/mortalidade , Ovinos , Doenças dos Ovinos/mortalidade , Reino UnidoAssuntos
Adenocarcinoma/veterinária , Doenças dos Bovinos/patologia , Complicações Neoplásicas na Gravidez/veterinária , Neoplasias das Glândulas Sudoríparas/veterinária , Cauda/patologia , Adenocarcinoma/patologia , Animais , Bovinos , Feminino , Gravidez , Complicações Neoplásicas na Gravidez/patologia , Neoplasias das Glândulas Sudoríparas/patologiaRESUMO
To examine and compare the pathogenicity of cytotoxic necrotising factor (CNF)-producing Escherichia coli, two litters of piglets were infected orally with 10(10) E coli O88 or 10(10) E coli O32 strains. Of the six piglets infected with E coli O88, two died within 24 hours and three developed blood-stained diarrhoea. The other piglets were killed one, five, six and eight days after infection, when bacterial cultures indicated an overwhelming bacteraemic infection with E coli O88 in the early stages followed by clearance through the large intestine. The pathological changes consisted of an early enteritis, progressing to enterocolitis and a bacteraemic spread to the lungs. The histopathological changes were characteristic of toxaemic effects in brain, heart, liver and kidney, and characterised by congestion, oedema and exudation. Infection with E coli O32 produced a milder but similar enterocolitis, also with bacterial colonisation in the lungs. The histopathological findings again reflected a toxaemia. The enteritis was more persistent after E coli O32 infection and the strain persisted in large numbers in the intestine. No evidence of bacterial adherence to the intestinal mucosa was found with either strain. Enteroinvasion was only evident in one E coli O88-infected piglet, but the consistent occurrence of interstitial pneumonia showed the predilection of these organisms for the lung. The results confirm the toxigenic properties of CNF+ E coli and suggest an important role for this organism in enteric infection of young pigs.
Assuntos
Toxinas Bacterianas/biossíntese , Citotoxinas/biossíntese , Infecções por Escherichia coli/fisiopatologia , Proteínas de Escherichia coli , Escherichia coli/patogenicidade , Animais , Animais Recém-Nascidos , Córtex Cerebral/patologia , Escherichia coli/isolamento & purificação , Infecções por Escherichia coli/patologia , Fezes/microbiologia , Feminino , Hiperplasia , Intestino Grosso/patologia , Pulmão/microbiologia , Pulmão/patologia , Masculino , Suínos , Células VeroAssuntos
Adesinas de Escherichia coli , Antígenos de Bactérias/análise , Antígenos de Superfície/análise , Doenças dos Bovinos/microbiologia , Colite/veterinária , Infecções por Escherichia coli/veterinária , Proteínas de Escherichia coli , Escherichia coli/isolamento & purificação , Proteínas de Fímbrias , Animais , Aderência Bacteriana , Toxinas Bacterianas/biossíntese , Bovinos , Colite/microbiologia , Citotoxinas/biossíntese , Escherichia coli/imunologia , Escherichia coli/patogenicidade , Infecções por Escherichia coli/microbiologia , Feminino , Fímbrias Bacterianas/imunologia , Hemorragia Gastrointestinal/microbiologia , Hemorragia Gastrointestinal/veterinária , Especificidade da EspécieAssuntos
Tratamento Farmacológico , Oftalmopatias/veterinária , Administração Tópica , Animais , Antibacterianos/uso terapêutico , Anti-Inflamatórios/uso terapêutico , Biofarmácia , Biotransformação , Olho/anatomia & histologia , Oftalmopatias/tratamento farmacológico , Oftalmopatias/metabolismo , Fenômenos Fisiológicos Oculares , Soluções Oftálmicas/metabolismoRESUMO
The safety of a 1:3 mixture of trimethoprim (TMP) and sulphaquinoxaline (SQX) for administration in food or water was assessed in broiler chickens, chicks of an egg laying strain and breeding fowl. The only effects recorded in six-week-old broilers medicated for seven days at levels ranging from 16 to 133 mg TMP plus SQX per kg bodyweight were decreases in water or food consumption, probably caused by unpalatability at overdosage levels, and associated decreases in weight gain and packed cell volume at an achieved overdose level of 4.4 times the recommended use concentration (RUC). Breeding fowl medicated at levels of 1 X or 3 X RUC for 14 days showed slightly reduced reproductive performance reflected by lowered egg production, egg weight and hatchability. These effects were temporary and performance equal to that of unmedicated birds was re-established by 14 days after medication ceased. Week-old chicks medicated for five days at levels from 0.7 to 4.7 X RUC showed normal growth rate over 12 days. Eleven-day-old chicks could not distinguish medicated from unmedicated water.
Assuntos
Infecções Bacterianas/veterinária , Galinhas , Coccidiose/veterinária , Doenças das Aves Domésticas/tratamento farmacológico , Sulfanilamidas/uso terapêutico , Sulfaquinoxalina/uso terapêutico , Trimetoprima/uso terapêutico , Ração Animal , Animais , Animais Recém-Nascidos/crescimento & desenvolvimento , Infecções Bacterianas/tratamento farmacológico , Coccidiose/tratamento farmacológico , Combinação de Medicamentos , Feminino , Masculino , Reprodução/efeitos dos fármacos , Sulfaquinoxalina/administração & dosagem , Trimetoprima/administração & dosagem , ÁguaRESUMO
A case of widespread spinal sarcoma is described with meningeal infiltration, involvement of the anterior cranial fossa complicated by aplastic anaemia and visceral metastases.
Assuntos
Sarcoma/diagnóstico , Neoplasias da Medula Espinal/diagnóstico , Adulto , Neoplasias Encefálicas/secundário , Diagnóstico Diferencial , Humanos , Masculino , Neoplasias Meníngeas/diagnóstico , Polirradiculoneuropatia/diagnósticoAssuntos
Nefopam/intoxicação , Oxazocinas/intoxicação , Suicídio , Adolescente , Adulto , Feminino , Humanos , MasculinoAssuntos
Doenças dos Bovinos/tratamento farmacológico , Salmonelose Animal/tratamento farmacológico , Sulfadiazina/uso terapêutico , Trimetoprima/uso terapêutico , Administração Oral , Animais , Bovinos , Combinação de Medicamentos , Sinergismo Farmacológico , Injeções Intramusculares , Injeções Intravenosas , Sulfadiazina/administração & dosagem , Sulfadiazina/sangue , Trimetoprima/administração & dosagem , Trimetoprima/sangueRESUMO
When young calves were dosed orally with 10(10) organisms of a culture of Salmonella dublin, typical symptoms of acute salmonellosis followed with a death rate of 86 per cent. Peak mortality occurred six days after infection. As a result of a statistical appraisal of the consistency of mortality in groups of untreated calves a model is proposed for the therapeutic evaluation of antibacterial compounds, which compares the number of survivors in groups of seven or eight calves with a minimum of four needed for significant indication of efficacy. Bacteriological and pathological investigations showed that the experimental disease was initially an acute systemic infection followed by severe enteritis. Measurements of plasma concentrations of enzymes and other constituents did not achieve the desired objective of establishing a method of quantitative evaluation of the clinical status of individual animals, although some changes occurred which were consistent with the pathology of the disease and suggested possible mechanisms by which jaundice occurred.
Assuntos
Doenças dos Bovinos/etiologia , Salmonelose Animal/etiologia , Doença Aguda , Animais , Bilirrubina/sangue , Bovinos , Doenças dos Bovinos/tratamento farmacológico , Doenças dos Bovinos/microbiologia , Doenças dos Bovinos/patologia , Diarreia/veterinária , Fezes/microbiologia , Febre/veterinária , Intestino Delgado/microbiologia , Intestino Delgado/patologia , Pulmão/patologia , Salmonelose Animal/tratamento farmacológico , Salmonelose Animal/microbiologia , Salmonelose Animal/patologiaRESUMO
A 45-year-old woman is reported with a history of recurrent bacterial infections since childhood; at the age of 37 years she developed recurrent ulcerated lesions around her mouth, in the groins and buttocks, which histologically contained small, non-caseating granulomas. A year latter when being treated for empyema, she was found to have common variable hypogammaglobulinaemia. Three years after this she developed a megaloblastic anaemia of vitamin B12-deficiency type.
Assuntos
Agamaglobulinemia/complicações , Anemia Perniciosa/etiologia , Granuloma/etiologia , Dermatopatias/etiologia , Agamaglobulinemia/genética , Feminino , Humanos , Pessoa de Meia-Idade , LinhagemAssuntos
Doenças dos Bovinos/sangue , Ceruloplasmina/sangue , Galinhas , Infecções por Escherichia coli/veterinária , Ferro/sangue , Doenças das Aves Domésticas/sangue , Salmonelose Animal/sangue , Animais , Bovinos , Diarreia/sangue , Diarreia/veterinária , Infecções por Escherichia coli/sangue , MasculinoRESUMO
Compared the frequency of two-point MMPI codes in four different alcoholism treatment facilities. Even though some differences were noted in terms of the different code types, the comparisons were more indicative of the similarity between treatment facilities. The 2-4/4-2 code type occurred most frequently in all of the treatment settings, yet it accounted for only 12--21% of the profiles in any facility. The implication of these findings for describing the "alcoholic" personality and for individualized treatment planning was discussed.