Assuntos
Dermatite Alérgica de Contato , Dermatite Ocupacional , Dermatoses da Mão , Dermatite Alérgica de Contato/diagnóstico , Dermatite Alérgica de Contato/etiologia , Dermatite Ocupacional/diagnóstico , Dermatite Ocupacional/etiologia , Luvas Protetoras/efeitos adversos , Dermatoses da Mão/induzido quimicamente , Humanos , Nitrilas/efeitos adversos , TiazóisRESUMO
BACKGROUND: Hand eczema (HE) is common and may follow a chronic disease course. So far, prospective studies investigating the risk factors for disease progression as a prerequisite for targeted prevention are scarce. OBJECTIVE: To evaluate the overall association of HE-associated factors with clinical and quality of life (QoL) improvement during a follow-up of 2 years. METHODS: Data of the prospective patient cohort (N = 199) followed by the Swiss chronic HE (CHE) registry on long-term patient management (CARPE-CH) were analysed by means of both classic regression and semantic map analyses. RESULTS: Both severity of HE and QoL significantly improved over the period of 2 years (P < .001). However, 20% of patients had moderate to severe HE after 2 years of follow-up. As factors associated with an unfavourable CHE clinical course and QoL, environmental exposures, male sex, occupational skin disease, job loss or change at baseline, allergic contact dermatitis, a chronic disease course, palmar localization and widespread eczema were identified. CONCLUSIONS: Analysis of prospective data from CARPE-CH shows a complex pattern of associations among variables as shown by semantic map and classic statistical analyses. Factors related to occupational exposure had the highest impact on CHE.
Assuntos
Dermatite Ocupacional/epidemiologia , Eczema/epidemiologia , Dermatoses da Mão/epidemiologia , Qualidade de Vida , Sistema de Registros , Doença Crônica/epidemiologia , Humanos , Exposição Ocupacional/estatística & dados numéricos , Estudos Prospectivos , Índice de Gravidade de Doença , Suíça/epidemiologiaAssuntos
Hemorragia Cerebral/imunologia , Hipersensibilidade Tardia/imunologia , Níquel/imunologia , Parestesia/imunologia , Stents/efeitos adversos , Biópsia , Doenças das Artérias Carótidas/cirurgia , Artéria Carótida Interna/diagnóstico por imagem , Artéria Carótida Interna/cirurgia , Hemorragia Cerebral/diagnóstico , Feminino , Humanos , Hipersensibilidade Tardia/diagnóstico , Aneurisma Intracraniano/cirurgia , Imageamento por Ressonância Magnética , Pessoa de Meia-Idade , Parestesia/diagnóstico , Testes do Emplastro , Pele/imunologia , Pele/patologiaRESUMO
Isothiazolinone is known to be a sensitizer and a frequent cause of contact dermatitis in adults. Cases of contact dermatitis have also recently been reported in children. Derivatives of isothiazolinone, such as methylisothiazolinone (MI) and methylchloroisothiazolinone (MCI), are commonly used in the care products of babies and children. This allergen should not be missed.