RESUMO
Chronic periodontit inflammation in old-aged patients was found to be accompanied by imbalance of complement system; sIgA, IgA, IgG and IgM hyperproduction; increased concentrations of IL-8, IL-1alpha and decreased level of IL-4; abrogated NO and its derivatives concentration; increased anti-HSP-70 and homocystein levels in blood and saliva. The obtained results justify the necessity to use in therapy of chronic parodontit inflammation the immunocorrection, antioxidant and bioregulatory therapy, which normalize the cells function.
Assuntos
Envelhecimento/sangue , Periodontite Crônica/sangue , Imunoglobulinas/sangue , Interleucinas/sangue , Isquemia Miocárdica/sangue , Idoso , Envelhecimento/imunologia , Anticorpos/sangue , Estudos de Casos e Controles , Periodontite Crônica/complicações , Periodontite Crônica/imunologia , Proteínas do Sistema Complemento/análise , Proteínas de Choque Térmico HSP70/imunologia , Humanos , Técnicas Imunoenzimáticas , Pessoa de Meia-Idade , Isquemia Miocárdica/complicações , Isquemia Miocárdica/imunologia , Óxido Nítrico/sangue , Saliva/imunologiaRESUMO
Chronic generalized periodontitis in the old-aged patients is accompanied by high levels of the antibodies to HSP, sIgA, IgM, IgG hyperproduction; elevated concentrations of IL-8 and IL-1alpha and low content of IL-4 in saliva and blood. Local anti-inflammatory therapy of chronic periodontitis does not restore normal immunity status. Appearance of antibodies to HSP plays a role in immune reactions, which maintain chronic inflammation of periodontium.
Assuntos
Periodontite Crônica , Proteínas de Choque Térmico HSP70 , Imunoglobulinas , Inflamação/imunologia , Interleucinas/metabolismo , Periodonto , Fatores Etários , Idoso , Envelhecimento/imunologia , Anti-Inflamatórios/uso terapêutico , Periodontite Crônica/tratamento farmacológico , Periodontite Crônica/imunologia , Periodontite Crônica/patologia , Monitoramento de Medicamentos , Feminino , Proteínas de Choque Térmico HSP70/imunologia , Proteínas de Choque Térmico HSP70/metabolismo , Humanos , Imunidade/efeitos dos fármacos , Imunoglobulinas/sangue , Imunoglobulinas/metabolismo , Fatores Imunológicos/metabolismo , Inflamação/tratamento farmacológico , Masculino , Pessoa de Meia-Idade , Periodonto/efeitos dos fármacos , Periodonto/imunologia , Periodonto/patologia , Saliva/imunologia , Resultado do TratamentoRESUMO
Chronic parodontit inflammation in elderly patients was found to be accompanied by inbalance of complement system; IgA (sIgA), IgA, IgG, IgM hyperproduction; the increase of IL-8, IL-1α concentration and decrease of IL-4 level; increase Hsp-70 antibodies.
Assuntos
Isquemia Miocárdica/imunologia , Doenças Periodontais/imunologia , Idoso , Doença Crônica , Proteínas do Sistema Complemento/análise , Feminino , Proteínas de Choque Térmico HSP70/imunologia , Humanos , Imunoglobulina A Secretora/análise , Imunoglobulina A Secretora/sangue , Imunoglobulina G/análise , Imunoglobulina G/sangue , Imunoglobulina M/análise , Imunoglobulina M/sangue , Interleucina-1alfa/análise , Interleucina-1alfa/sangue , Interleucina-8/análise , Interleucina-8/sangue , Masculino , Pessoa de Meia-Idade , Isquemia Miocárdica/sangue , Isquemia Miocárdica/complicações , Doenças Periodontais/sangue , Doenças Periodontais/complicaçõesRESUMO
It was revealed that patients suffering from the diabetes mellitus type 1 (DM-1) on the stage of destabilization report accelerated blood coagulability, decreased content of natural anticoagulators (antithrombin III and protein C), increased concentration of fibrogene and soluble fibrinmonomer complexes and reduced fibrinolysis. The obtained data testify the development of chronic form of DIC syndrome, moreover there is a correlation between the age of the patient, the severity of the disease, insulin dose, presence and severity of the complications on the one hand and the intensity of DIC syndrome on the other hand. Generally accepted treatment of the DM-1 patients doesn't exert considerable effect on the processes of intravascular blood coagulation. Meanwhile administration of thymomimetic Vilon (Lys-Glu) in these patients significantly reduces or even totally diminishes DIC syndrome. In elderly patients with severe form of the disease the effect of Vilon on coagulative hemostasis and blood fibrinolytic activity is less pronounced.