A climate vulnerability assessment of the fish community in the Western Baltic Sea.

Marine fisheries are increasingly impacted by climate change, affecting species distribution and productivity, and necessitating urgent adaptation efforts. Climate vulnerability assessments (CVA), integrating expert knowledge, are vital for identifying species that could thrive or suffer under changing environmental conditions. This study presents a first CVA for the Western Baltic Sea's fish community, a crucial fishing area for Denmark and Germany. Characterized by a unique mix of marine, brackish, and freshwater species, this coastal ecosystem faces significant changes due to the combined effects of overfishing, eutrophication and climate change. Our CVA involved a qualitative expert scoring of 22 fish species, assessing their sensitivity and exposure to climate change. Our study revealed a dichotomy in climate change vulnerability within the fish community of the Western Baltic Sea because traditional fishing targets cod and herring as well as other species with complex life histories are considered to face increased risks, whereas invasive or better adaptable species might thrive under changing conditions. Our findings hence demonstrate the complex interplay between life-history traits and climate change vulnerability in marine fish communities. Eventually, our study provides critical knowledge for the urgent development of tailored adaptation efforts addressing existing but especially future effects of climate change on fish and fisheries in the Western Baltic Sea, to navigate this endangered fisheries systems into a sustainable future.

Neurological telerehabilitation in the COVID-19 era - current perspectives through a bibliometric analysis.

Objective: To identify bibliometric parameters and research trends regarding to telerehabilitation of patients with stroke in the COVID-19 era. Methodology: This is an integrative review carried out in the Scopus database, from June to July 2021, through the Biblioshiny graphical interface, provided by the Bibliometrix program. The search terms used were "Stroke," "COVID-19" and "Telerehabilitation." Results were filtered by publication date from 2019 onwards. No language restrictions were imposed. Results: Twenty two articles were included in the study and the results were presented in the form of figures demonstrating that the journal Frontiers in Neurology was the one with the most relevant studies and the author with the highest number of citations. The Brazilian Academy of Neurology was the institution with the greatest number of studies and China ranked first as the country with the greatest scientific production. The authors used recent references in their work. A thematic map showed the centrality and density of the words presented and, finally, a three-field graph showed a strong intimacy between countries, keywords and authors. Conclusion: A greater interest in the subject was observed in China with greater relevance of journals and institutions focused on neurology. However, despite telerehabilitation being an effective alternative in the context of the pandemic, few studies have explored this modality.

Neurological syndromes and potential triggers associated with antibodies to neuronal surface antigens.

BACKGROUND: Autoantibodies against surface neuronal antigens have been associated with specific neurological presentations including autoimmune encephalitis (AE), with variable association with neoplasia and infections. METHODS: We described the phenotype and environmental associations of patients with neurological syndromes associated with antibodies against neuronal surface antigens who were referred to a tertiary center in the South of Brazil. All patients were tested for neuronal autoantibodies using cell-based assays. Clinical, radiological, and laboratory findings were retrospectively reviewed. RESULTS: We identified 16 patients, 15 had subacute, and one had a progressive disease course. Among patients with subacute onset, 11 (73 %) were N-Methyl-d-Aspartate receptor (NMDAr-IgG)+, 3 (20 %) were Leucine-rich Glioma-Inactivated-1 (LGI1-IgG)+, and 1 (6 %) was positive for Glycine receptor-IgG. The patient with a progressive disease course had antibodies against IgLON5. Most patients had disease onset in spring and summer suggesting environmental factors for the development of AE. Also, we observed a different pattern of brain lesions when NMDAr-IgG encephalitis followed herpes encephalitis and a previously unreported association with Rosai-Dorfman-Destombe disease. All patients with encephalopathy met criteria for possible AE and all proven NMDAr-IgG+ met criteria for NMDAr-IgG encephalitis. However, only one LGI1-IgG+ patient fulfilled clinical criteria for limbic encephalitis. All but one received high-dose intravenous methylprednisolone, 11 also had intravenous human immunoglobulin, and 4 plasma exchange. Furthermore, all patients received second-line immunotherapy. Importantly, most patients improved with immunotherapy, even when initiated later in the disease course. CONCLUSION: We identified seasonal variability associated with neuronal surface antibodies suggesting environmental triggers. Also, we described the coexistence of NMDAr-IgG encephalitis with histiocytosis. In our series, most patients received second-line immunotherapy. We observed neurologic improvement after treatment even in cases of delayed diagnosis. Increasing the recognition and availability of tests and treatments for these conditions is of paramount importance in low- and middle-income countries.

Stress-relaxation properties of French fries as a function of moisture content, oil content, frying temperature, and testing temperature.

There is insufficient information on the effect of temperature, moisture content (MC), and oil concentration on the mechanical properties of fried potatoes. The static mechanical testing capabilities of a dynamic mechanical analyzer (DMA) were utilized to measure the stress relaxation function of fried potatoes as a function of frying time, temperature, and testing temperature. The French fries were prepared in oil heated at 177°C, 184°C, and 191°C, and their MC and oil content (OC) values were measured as a function of frying time. The samples loaded in DMA were subjected to 2% strain, and the stress relaxation was performed for 600 s. The DMA furnace temperature was set at 37°C, 60°C, and 90°C. A two-element generalized Maxwell model was fitted into the DMA data. French Fries lost more than 70% of their moisture and absorbed more than 80% of their final OC during the first 180 s of frying. During the same interval (up to 180 s), the relaxation modulus parameters (G0 , G1 , and G2 ) did not change significantly and then increased linearly. These parameters also did not change considerably for MC above 2 g/g solids. At lower MC values, G1 and G2 increased as the MC was reduced, but the elastic modulus G0 stayed almost constant, independent of the MC.

Bioequivalence of 2 formulations of montelukast (5 mg chewable tablet) in the fasting state: an open-label randomized, single-dose, 2-period, crossover study / Estudo de bioequivalência entre duas formulações de comprimidos mastigáveis de Montelucaste de 5 mg em condições de jejum: um estudo randomizado, de dose única, aberto, dois períodos, cruzado

Introduction: Montelukast, a selective and active leukotriene receptor antagonist, is one of the most common agents in asthma treatment for both adults and children. Objective: To assess whether the pharmacokinetic profiles of two formulations of montelukast were similar after a single 5 mg dose (chewable tablets), administered orally under fasting conditions, sampling blood before and 36 hours after administration. Methods: This was a randomized, 2-sequence, 2-period, crossover study of 2 chewable tablet formulations of the drug: Singulair®, provided by Merck Sharp and Dohme Farmacêutica Ltda. (reference), and generic montelukast, manufactured by Eurofarma Laboratórios S.A. (test). Plasma samples obtained from 35 participants were analyzed for montelukast through high-performance liquid chromatography coupled to tandem mass spectrometry, with montelukast-d6 as the internal standard. Peak montelukast concentrations were 299.313 (SD, 11.039) ng/mL for the reference formulation and 279.803 (SD, 10.085) ng/mL for test formulation. Results: Statistical analysis showed no significant differences between AUC0-36h, AUC0-inf, or Cmax between formulations, with the following test/reference ratios: 102.458 for AUC0-36h, 102.522 for AUC0-inf, and 93.490 for Cmax. No serious adverse events were reported during the trial. Our results demonstrated the bioequivalence of Singulair® and Eurofarma's generic montelukast. Conclusions: Our results revealed that the new generic tablets are clinically safe and can be used interchangeably with the brand name product. Eurofarma's montelukast offers a safe, effective, and cheaper treatment option for people with asthma or allergic rhinitis.

Introdução: O montelucaste, um antagonista seletivo e ativo dos receptores de leucotrienos, é um dos agentes mais comumente usados na prática clínica no tratamento da asma, tanto em adultos quanto em crianças. Objetivo: Avaliar se os perfis farmacocinéticos de duas formulações de montelucaste eram semelhantes após uma dose única de comprimidos mastigáveis de 5 mg, administrados por via oral em jejum, coletando amostras de sangue desde antes da administração até 36 horas depois disso. Métodos: Estudo comparativo randomizado, 2 sequências e 2 períodos, cruzado, de dois medicamentos em comprimidos mastigáveis: Singulair®, fornecido pela Merck Sharp e Dohme Farmacêutica Ltda. (referência) e Montelucaste 5 mg, fabricado pela Eurofarma Laboratórios S.A. (teste). Amostras de plasma obtidas de 35 indivíduos elegíveis foram analisadas para montelucaste por cromatografia líquida de alta eficiência acoplada a espectrometria de massa em tandem, tendo Montelucaste-d6 como padrão interno. As concentrações máximas de montelucaste foram 299,313±11,039 ng/mL para referência e 279,803±10,085 ng/mL para formulação de teste. Resultados: A análise estatística não mostrou diferenças significativas para AUC0-36h, AUC0-inf e nem para Cmax entre as formulações, apresentando as razões Teste/Referência: 102,458 para AUC0-36h, 102,522 para AUC0-inf e 93,490 para Cmax. Nenhum evento adverso grave foi relatado durante o estudo. De acordo com a regulamentação brasileira, o atual estudo farmacocinético demonstrou bioequivalência entre os agentes individuais e forneceu evidências de bioequivalência entre Singulair® e Montelukast fabricado pela Eurofarma. Resultado: Os resultados mostraram que os novos comprimidos genéricos são clinicamente seguros e podem ser trocados pela marca original. O montelucaste da Eurofarma oferece uma opção de tratamento mais barata, segura e eficaz para indivíduos com asma ou rinite alérgica.

Análise da produção científica e fomento dos bolsistas de produtividade do CNPQ em educação física no período de 2010-2020 / Analysis of scientific production and foment of grant holders of CNPQ in physical education in the period of 2010-2020 / Análisis de la producción científica y fomento de los becarios de productividad del CNPQ en educación física en el período 2010-2020

O objetivo deste estudo foi analisar as concessões de bolsas e a produção científica dos bolsistas de produtividade do CNPq, na área de Educação Física, no período de 2010-2020. A busca dos pesquisadores com bolsa de produtividade na área da Educação Física ocorreu na página eletrônica do CNPq. A contabilização dos dados registrados nos currículos dos bolsistas ocorreu com auxílio do software scriptLattes v8.10. Verificou-se que: a) a publicação de artigos se elevou no decorrer do período analisado; b) os artigos de estrato elevado no Qualis (A1, A2 e JCR) mantiveram um crescimento constante; c) a produção de itens não contabilizados pelos critérios de concessão de bolsa permaneceu estável; d) houve renovação parcial dos pesquisadores bolsistas de produtividade. Concluiu-se que os bolsistas de produtividade têm ampliado sua produção e fortalecendo suas métricas. No entanto, é necessária a constante revisão dos critérios de concessão a fim de minimizar o produtivismo acadêmico. (AU)

The study aims to analyze the concession of grants and the scientific production of grant holders of the National Council for Scientific and Technological Development (CNPq), in the Physical Education area, in the period of 2017-2020. The search for grant holders in the Physical Education area was obtained through the CNPq website. It accounted for the data of curriculum Lattes through software scriptLattes v8.10. We found that: a) the publication of papers increased during the analyzed period; b) high-level papers (A1, A2, and JCR) had steady growth; c) production of items not accounted for grant guidelines were static; d) there is partial renovation of grant holders. We concluded that grant holders have expanded their production and strengthened their metrics. However, it is necessary to constantly revise grant guidelines to minimize academic productivism. (AU)

El objetivo de este estudio fue analizar la concesión de bacas y la producción científica de los becarios de productividad del CNPq, en el campo de la Educación Física, en el período 2010-2020. La búsqueda de investigadores con beca de productividad en el área de Educación Física se realizó en el sitio web del CNPq. La contabilización de los datos registrados en los currículos de los becarios se realizó a través del software scriptLattes v8.10. Se encontró que: a) la publicación de artículos aumentó durante el periodo analizado; b) los artículos de alto nivel (A1, A2 y JCR) mantuvieron un crecimiento constante; c) la producción de elementos no contabilizados por los criterios de concesión de bacas se mantuvo estable; d) hay renovación parcial de los investigadores becarios de productividad. Se concluye que los becarios de productividad han ampliado su producción y fortalecido sus métricas. Sin embargo, es necesario revisar constantemente los criterios de concesión para minimizar el productivismo académico. (AU)

Judicialização no acesso a medicamentos: os números no período de 2019 a 2021 no município de Ponta Grossa, Paraná / Judicialization in access to medicines: the numbers in the period from 2019 to 2021 in the municipality of Ponta Grossa, Paraná

descrever o perfil das ações judiciais quanto ao fornecimento de medicamentos no município de Ponta Grossa, Paraná, entre 2019 a 2021. Metodologia: Utilizou-se o método descritivo-exploratório e retrospectivo, de abordagem quantitativa. Foram analisados 89 processos, sendo grande parte dos autores do sexo feminino (57,3%), com predomínio de assistência jurídica pública por meio do Ministério Público (69,7%) e com prescrições do serviço público (96,6%). Resultados: Observou-se que 93,3% das solicitações não constavam na Relação Nacional de Medicamentos Essenciais. Ademais, verificou-se maior demanda do medicamento Avastin (31,5). As doenças que mais acometeram a parte autora foram retinopatia diabética (42,7%; n=38) e doença pulmonar obstrutiva crônica (24,7%). Destaca-se que no período da coleta de dados, 79,8% dos processos encontravam-se finalizados. Os valores gastos com a judicialização de medicamentos variaram de R$ 407,94 a R$ 47.220,00. Considerações: Haja vista o número não exorbitante de ações judiciais, é possível que existam estratégias municipais efetivas, ou a ausência de Defensoria Pública no atendimento as demandas de saúde, pode ter tornado fator inibidor de acesso à justiça. Outro ponto quanto a delimitação no acesso, são os requisitos cumulativos firmados na tese pelo STF, quanto a concessão de medicamentos não previstos nas listas de dispensação do SUS. Conclui-se que há necessidade de aprimorar o diálogo entre o judiciário e o setor de saúde por meio dos seus gestores, bem como a realização de mais estudos para subsidiar um mapeamento, planejamento, descrição de gastos com a judicialização, aquisição de medicamentos e incorporação de novas tecnologias

Objective: to describe the profile of lawsuits regarding the supply of medicines in the city of Ponta Grossa, Paraná, between 2019 and 2021. Methods: A descriptive-exploratory and retrospective method was used, with a quantitative approach. A total of 89 processes were analyzed, most of which were female authors (57.3%), with a predominance of public legal assistance through the Public Prosecutor's Office (69.7%) and with prescriptions from the public service (96.6%). Results: It was observed that 93.3% of requests were not included in the National List of Essential Medicines. Furthermore, there was a greater demand for the drug Avastin (31.5). The diseases that most affected the author were diabetic retinopathy (42.7%; n=38) and chronic obstructive pulmonary disease (24.7%). It is noteworthy that during the data collection period, 79.8% of the processes were concluded. The amounts spent on the legalization of medicines ranged from R$ 407.94 to R$ 47,220.00. Considerations: Given the not exorbitant number of lawsuits, it is possible that there are effective municipal strategies, or the absence of a Public Defender's Office in meeting health demands, which may have become an inhibiting factor in access to justice. Another point regarding the delimitation of access, are the cumulative requirements signed in the thesis by the STF, regarding the concession of medicines not foreseen in the SUS dispensing lists. It is concluded that there is a need to improve the dialogue between the judiciary and the health sector through its managers, as well as to carry out more studies to support a mapping, planning, description of expenses with the judicialization, acquisition of medicines and incorporation of new technologies

Bioequivalence/bioavailability Study of a New Formulation of Imatinib Mesylate 100 mg Coated Tablets versus Glivec® in Brazilian Healthy Male Volunteers in Fed State / Estudo de Bioequivalência/Biodisponibilidade de uma Nova Formulação de Mesilato de Imatinibe versus Glivec® em Voluntários Saudáveis Brasileiros em Condições Alimentares / Estudio de Bioequivalencia/Biodisponibilidad de una Nueva Formulación de Mesilato de Imatinib versus Glivec® en Voluntarios Saludables Brasileños Bajo Condiciones Alimentarias

Introduction: Imatinib mesylate is currently the first-line oral treatment for all stages of chronic myeloid leukemia (CML) and is also used in some cases of gastrointestinal stromal tumor (GIST) and acute lymphoblastic leukemia (ALL). Objective: Investigate the bioavailability of two products containing imatinib mesylate, 100 mg coated tablet, to determine if they are bioequivalent. Method: The study was conducted using an open-label, randomized, balanced design and the formulations were administered orally in a single dose to 48 healthy adult males, in fed state, followed by sequential blood withdraws for the next 72 hours. Forty-eight male healthy volunteers were selected to participate in the study. Test formulation from Eurofarma Laboratórios S.A. Brazil was compared to from Novartis Biociências S.A. The comparative bioavailability of the formulations was assessed based on statistical comparisons of relevant pharmacokinetic parameters obtained from drug concentration data from collected blood samples measured using an analytical method based on high-performance liquid chromatography coupled to mass spectrometry. Results: The ratio of the geometric means between the test and the reference, with a 90% confidence interval, of pharmacokinetic parameters for Cmax was 102.26% (94.17-111.04%) and for AUC0-t was 101.24% (95.19-107.68%). Conclusion: Imatinib mesylate 100 mg (test product) from Eurofarma Laboratórios S.A. was considered bioequivalent to the reference Glivec® 100 mg manufactured by Novartis Biociências S.A, and the test product can be interchangeable with the reference, based on their pharmacokinetic performance

Introdução: O mesilato de imatinibe é atualmente o tratamento oral de primeira linha para todos os estágios de leucemia mieloide crônica (LMC) e é usado também em alguns casos de tumores gastrointestinais (GIST) e na leucemia linfoide aguda (LLA). Objetivo: Investigar a biodisponibilidade de dois produtos contendo mesilato de imatinibe de 100 mg em comprimidos revestidos para determinar se são bioequivalentes. Método: Estudo conduzido usando um desenho aberto, randomizado e balanceado. As formulações foram administradas de forma oral em única dose a 48 participantes saudáveis do sexo masculino após alimentação, seguido de coletas de sangue por 72 horas. Quarenta e oito participantes saudáveis foram selecionados para participar do estudo. A formulação teste da Eurofarma Laboratórios S.A. foi comparada com a formulação referência da Novartis Biociências S.A. A biodisponibilidade relativa das formulações foi avaliada em comparações estatísticas dos parâmetros farmacocinéticos relevantes obtidos de concentrações de droga das amostras coletadas mediante a utilização de um método analítico baseado em cromatografia líquida de alta performance acoplada à espectrometria de massas. Resultados: A razão das médias geométricas entre teste e referência com intervalo de confiança 90% dos parâmetros farmacocinéticos para Cmáx foi de 102,26% (94,17-111,04%) e para ASC0-t foi de 101,24% (95,19-107,68). Conclusão: Mesilato de imatinib 100 mg (produto teste) da Eurofarma Laboratórios S.A. foi considerado bioequivalente ao Glivec® 100 mg produzido por Novartis Biociências S.A., e o produto teste pode ser intercambiável como referência com base em seu desempenho farmacocinético

Introducción: El mesilato de imatinibe es actualmente el tratamiento oral de primera línea para todos los estadios de leucemia mieloide crónica (LMC) y es usado también en algunos casos de tumores gastrointestinales (GIST) y leucemia linfoide aguda (LLA). Objetivo: Investigar la biodisponibilidad de dos productos de mesilato de imatinibe de 100 mg en comprimidos revestidos para determinar si son bioequivalentes. Método: Estudio ejecutado usando un diseño abierto, aleatorizado y balanceado. Las formulaciones fueron administradas de forma oral en dosis única a 48 participantes saludables de sexo masculino en condiciones de alimentación, seguidas de muestras de sangre por 72 horas. Cuarenta y ocho participantes saludables fueron seleccionados para participar del estudio. La formulación de prueba de Eurofarma Laboratórios S.A. fue comparada con la formulación referencia de Novartis Biociências S.A. La biodisponibilidad relativa de las formulaciones fue evaluada mediante comparaciones estadísticas de los parámetros farmacocinéticos relevantes obtenidos de concentraciones del fármaco de muestras recolectadas con la utilización de un método analítico basado en cromatografía de alto rendimiento acoplada a espectrometría de masas. Resultados: La relación de las medias geométricas entre la prueba y la referencia con un intervalo de confianza del 90% de los parámetros farmacocinéticos para Cmax fue 102,26% (94,17-111,04%) y para AUC0-t fue 101,24% (95,19-107,68). Conclusión: El mesilato de imatinib 100 mg (producto de prueba) de Eurofarma Laboratórios S.A. fue considerado bioequivalente al Glivec® 100 mg producido por Novartis Biociências S.A. y el producto de prueba puede ser intercambiable con el de referencia en función de su desempeño farmacocinético

Effect of different adhesive strategies on the microtensile bond strength of dentin to indirect resin-based composite.

BACKGROUND: To evaluate the microtensile bond strength of indirect resin composite bonded to dentin using five different adhesives strategies. MATERIAL AND METHODS: Forty specimens (Solidex) were produced and randomly into five groups with different adhesives strategies: (G1)- Single Bond Universal + etch + silane + RelyX Ultimate, (G2)- Single Bond Universal + silane + RelyX Ultimate, (G3)- Single Bond Universal + etch + RelyX Ultimate, (G4)- Single Bond Universal + RelyX Ultimate, and (G5)-Scotchbond Multi-purpose + RelyX ARC. After cementation the specimens were stored in 100% humidity for 24hours at 37°C. The specimens were sectioned perpendicular to the adhesive interface to obtain beams and submitted to microtensile test. Microtensile values were expressed in MPa and analyzed by one-way ANOVA and multiple comparison Tukey tests (α=0.05). RESULTS: The mean bond strength in MPa groups were: G1=11,48, G2=14,15, G3=16,95, G4=17,03 and G5=16,80. Statistical analysis showed that the bond strength values were not significantly affected by the different adhesive strategies. CONCLUSIONS: Cementation of dentin to indirect resin composite cannot be significantly affected by different adhesive strategies used. The specimens treated with silane, etch associated with Single bond universal did not increase bond strength values. Key words:Adhesives, dental cements, dentin.

A Practical Method for QTc Interval Measurement.

Objective The various formulae used for QT correction by heart rate (HR) require the execution of operations with the aid of calculators or applications. This study aimed to evaluate the performance of a simple rule for QTc estimation, comparing the measurements obtained with those provided by the commonly used equations of Bazett, Fridericia, Framingham, and Hodges. Methods We used the database of a previous observational study, which analyzed patients prospectively with acute pulmonary edema admitted in an emergency service. One hundred four patients were included for QTc assessment, of whom 86 patients underwent two ECG: one ECG <24h and other >24h after admission. Thus, a total of 190 ECGs were analyzed by two observers that manually measured QT and HR. QTc was obtained using the known formulae and the proposed equations: QTc = QT+2 (FC-60) for HR ≤ 90 bpm and QTc=QT+2(FC-60)-10 for HR>90 bpm. Results Bland-Altman plots show good agreement between the simple rule and Hodges equation, with a mean difference of -3,4, SD of 4.96 and 95% limits of agreement from -9,9 to 3.2. There was not a good agreement between the simple method and the other formulae. Conclusion The proposed method has good agreement with the measures of QTc by the equation of Hodges in the HR range of 40 to 130bpm in acutely ill patients. Our method may be a plausible option for quick QT correction in these subjects.

Esporte e lazer: caracterização e análise dos grupos de pesquisa no Brasil que abordam tais objetos / Sport and leisure: characterization and analysis of research groups in Brazil dealing with these objects

O presente artigo, de cunho exploratório, analisa a estruturação do subcampo formado pelos grupos de pesquisa em Esporte e Lazer cadastrados no Diretório de Grupos de Pesquisa no Brasil (DGP), em busca realizada no último dia do ano de 2016. Buscou-se examinar como os grupos são formados, onde estão localizados, os periódicos em que ocorrem suas produções e a vinculação dos líderes em programas de Pós-Graduação. Para tal, efetuou-se uma análise a partir das informações quantitativas fornecidas pelo DGP e currículos Lattes dos referidos líderes, subsidiados pela teoria dos campos do sociólogo Pierre Bourdieu. Conclui-se que os Grupos de Pesquisa em esporte e lazer apresentam íntima relação com a área da Educação Física, e estão distribuídos por todo o Brasil. Entretanto, a inexistência de uma cadeia de interdependência entre estes prejudica a compreensão mais precisa de como tem se desenvolvido o esporte e lazer no Brasil.

The present exploratory article analyzes the structuring of the subfield that encompasses Sport and Leisure research groups that were accordingly registered in the "Diretório de Grupos de Pesquisa no Brasil" (DGP, "Brazilian Directory of Research Groups", our translation) until the last day of 2016. We attempted to examine how these groups were founded, where they are located, which journals their productions were published and the affiliation of the leader groups in Post-Graduation programs. Proceeding from the quantitative information provided by DGP, the Lattes academic curricula database and the theoretical background built on the French sociologist Pierre Bourdieu, we attempted to analyze these elements in light of the Field Theory, so that some logical disputes, which can be found in this subarea, can be understood. We concluded that the Sport and Leisure Research Groups are closely related with the Physical Education area and are spread throughout Brazil. However, the lack of an interdependence chain between these groups jeopardize the better comprehension of how sport and leisure have been developed in Brazil.

Ecological-economic sustainability of the Baltic cod fisheries under ocean warming and acidification.

Human-induced climate change such as ocean warming and acidification, threatens marine ecosystems and associated fisheries. In the Western Baltic cod stock socio-ecological links are particularly important, with many relying on cod for their livelihoods. A series of recent experiments revealed that cod populations are negatively affected by climate change, but an ecological-economic assessment of the combined effects, and advice on optimal adaptive management are still missing. For Western Baltic cod, the increase in larval mortality due to ocean acidification has experimentally been quantified. Time-series analysis allows calculating the temperature effect on recruitment. Here, we include both processes in a stock-recruitment relationship, which is part of an ecological-economic optimization model. The goal was to quantify the effects of climate change on the triple bottom line (ecological, economic, social) of the Western Baltic cod fishery. Ocean warming has an overall negative effect on cod recruitment in the Baltic. Optimal management would react by lowering fishing mortality with increasing temperature, to create a buffer against climate change impacts. The negative effects cannot be fully compensated, but even at 3 °C warming above the 2014 level, a reduced but viable fishery would be possible. However, when accounting for combined effects of ocean warming and acidification, even optimal fisheries management cannot adapt to changes beyond a warming of +1.5° above the current level. Our results highlight the need for multi-factorial climate change research, in order to provide the best available, most realistic, and precautionary advice for conservation of exploited species as well as their connected socio-economic systems.

O que os olhos não veem, mas o coração sente: classificação per capita e por faturamento do quadro de medalhas dos Jogos Paralímpicos Rio-2016 / Out of sight, but not out of mind: classification per capita and by billing of the medal board at the Paralympic Games Rio 2016 / Ojos que no ven, corazón que siente: clasificaciones per cápita y por facturación del medallero en los Juegos Paralímpicos de Rio 2016

Resumo Objetivou-se analisar o quadro de medalhas dos jogos Paralímpicos Rio-2016 considerando o número de habitantes e o Produto Interno Bruto (PIB) dos países medalhistas. Inferiu-se que as primeiras colocações dos jogos Paralímpicos no quadro de medalhas usado pela mídia foram ocupadas por países com maior potencial econômico, o que foi reforçado pelos cálculos de correlação de Spearman entre as variáveis investigadas neste estudo. Observou-se, ainda, que o Brasil, mesmo não tendo obtido um desempenho ruim, apresenta um grande potencial de melhoria no número de medalhas de ouro e total de medalhas, tendo em vista seu tamanho populacional e PIB.

Abstract We objectified to analyze the medal board of the Rio 2016 Paralympic Games considering the number of inhabitants and the Gross Domestic Product (GDP) of medalist countries. We inferred that the first positions of the Paralympic Games medal table used by the media were occupied by countries with greater economic potential, which was reinforced by Spearman correlation calculations between the variables investigated in this study. We also noted that Brazil, even not having obtained poor performance, has a great potential for improvement in the number of gold and total medals, given its population size and GDP.

Resumen El objetivo fue analizar el medallero de los Juegos Paralímpicos de Rio 2016 según el número de habitantes y el Producto Interior Bruto (PIB) de los países medallistas. Se comprobó que las primeras posiciones del medallero de los Juegos Paralímpicos utilizados por los medios de comunicación estaban ocupados por países con mayor potencial económico, algo que fue reforzado por medio del cálculo de la correlación de Spearman entre las variables investigadas en este estudio. Se observó también que Brasil, a pesar de no haber obtenido bajo rendimiento, tiene un elevado potencial de mejora en el número de medallas de oro y total de acuerdo con el tamaño de su población y el PIB.

Análise da produção técnico-científica dos bolsistas de produtividade do CNPQ da área de educação física no triênio 2010-2012 / Analysis of technical-scientific production of CNPQ researchers grant in physical education area in 2010-2012 triennium / Análisis de la producción técnico-científica del los pesquisidores con beca de productividad en el área de educación física en el trienio 2010-2012

O presente estudo objetivou analisar a produção técnico-científica dos bolsistas de produtivi-dade da área da Educação Física no triênio 2010-2012. A relação de bolsistas de produtivida-de foi obtida por meio da página eletrônica do CNPq, tendo sido posteriormente buscados seus currículos na Plataforma Lattes e contabilizadas, por meio do software scriptLattes v8.07, sua produção bibliográfica, técnica e artística e as orientações concluídas. Constatou-se que estes visam prioritariamente publicações em periódicos de Qualis A1, A2 e B1, bem co-mo orientações de mestrado e doutorado. Conclui-se que os bolsistas de produtividade da área da Educação Física tendem a direcionar suas produções para atender aos requisitos estipula-dos pelo CNPq para manutenção/ascensão da bolsa de produtividade.

This study objectified to analyze the technical-scientific production of researchers grant in Physical Education area in 2010-2012 triennium. The list of researchers grant was obtained through CNPq website, so their curriculum was searched in Lattes Platform and we accounted through scriptLattes v8.07 software their bibliographical, technical and artistic production such as completed guidance. We found that they primarily look for publications in Qualis A1, A2 and B1 journals, as well as master and PhD guidance. We concluded that researchers grant in Physical Education tend to direct their production to meet the requirements stipulated by the CNPq for maintenance/rise of the grant.

Este estudio tiene el objetivo de analizar la producción técnico-científica de los becarios de productividad del área de Educación Física durante el periodo 2010 a 2012. La lista de los becarios de productividad se obtuvo a través de la página electrónica del CNPq, loscurrículos correspondientes se buscaron posteriormente en la Plataforma Lattes y la producción biblio-gráfica, técnica y artística, bien como las orientaciones finalizadas identificadas en esos cu-rrículos se contabilizaron a través del software scriptLattes v8.07. Se constató que esos beca-rios buscan principalmente publicaciones en periódicos con Qualis A1, A2 y B1, así como orientaciones de maestría y doctorado. Se concluye que los pesquisidores con beca de produc-tividad en el área de Educación Física tienden a dirigir su producción a la finalidad de cumplir con los requisitos estipulados por el CNPq para el mantenimiento/progresión de la beca.

Bioequivalência de cloridrato de propafenona 300mg em comprimido revestido em administração pós-prandial em adultos saudáveis / Bioequivalence of propafenone hydrochloride 300mg film coated tablets in healthy adults

OBJETIVO: Avaliar a bioequivalência de duas formulações de cloridrato de propafenona 300mg em comprimido revestido.MÉTODOS: Estudo randomizado, cruzado, aberto, com dois tratamentos, duas sequências e quatro períodos com 60 participantes sadios de ambos os sexos. Os voluntários foram internados em quatro oportunidades durante 24 horas; em cada período, os sujeitos receberam a formulação teste ou a formulação referência, em regime pós-prandial. Foram coletadas 23 amostras de sangue após administração da droga para determinação plasmática da propafenona. Para quantificação da droga, foi utilizada técnica de cromatografia líquida acoplada à espectrometria de massas sequencial. RESULTADOS: As formulações foram consideradas clinicamente bem toleradas. A concentração máxima e a área sob a curva de zero a 36 horas foram comparadas: a média geométrica da razão entre as formulações teste e referência para concentração máxima foi de 110,16%, com intervalo de confiança de 99,44% a 122,04% e coeficiente de variação de 33,95%. A média geométrica da razão entre as formulações teste e referência para a área sob a curva de zero a 36 horas foi de 107,92%, com intervalo de confiança de 99,58% a 116,96% e coeficiente de variação de 26,39%. A média geométrica da razão entre o medicamento teste e referência para área sob a curva de zero ao infinito foi de 107,12%, com intervalo de confiança de de 99,11% a 115,78% e coeficiente de variação de 25,48%. CONCLUSÃO: As formulações teste e referência foram estatisticamente bioequivalentes, de acordo com sua taxa e extensão de absorção.

OBJECTIVE: To evaluate the bioequivalence of two 300mg profanone hydrochloride coated tablets. METHODS: Randomized, cross-over, openstudy, with two treatments, two sequences, and four periods with 60 healthy participants of both genders. The volunteers were admitted in four opportunities over 24 hours; on each period, the subjects received a test formulation, or a reference formulation, in a postprandial administration. Twenty-three samples of blood were collected after oral administration of the drug for determining plasma level of propafenone. Liquid chromatography-mass spectrometry was used for quantifying propafenone. RESULTS: The formulations were considered clinically well tolerated. The maximum concentration and the area under the curve from zero to 36 hours were compared: the geometric mean of the ratio between the test and reference formulations for maximum concentration was 110.16%, with confidence interval of 99.44% - 122.04%), coefficient of variation of 33.95%. The geometric mean of the ratio between the test and reference formulations for the area under the curve of zero to 36 hours was 107.92%, with confidence interval of 99.58% - 116.96%, and coefficient of variation of 26.39%. The geometric mean of the ratio between the formulations for area under the curve of zero to infinitum as 107.12% with confidence interval of 99.11% - 115.78%),and coefficient of variation of 25.48%. CONCLUSION: According to the rate and extension of absorption, the test and reference formulations are statistically bioequivalent.

Expanded commuting in the metropolitan region of Belo Horizonte: evidence for reverse commuting / Comutação ampliada na Região Metropolitana de Belo Horizonte: evidências à mobilidade pendular inversa / Conmutación ampliada en la Región Metropolitana de Belo Horizonte: evidencias de la movilidad pendular inversa

Large Brazilian cities, particularly those that have experienced rapid population growth since the middle of the last century, have exhibited significant signs of population dispersion in their peripheries in recent decades. A study of the population's spatial redistribution in the Metropolitan Region of Belo Horizonte (MRBH) confirms this finding. In the process of dispersion, the levels of urban commuting increase, and commuting becomes a relevant indicator of the degree of integration within the metropolis. This paper evaluates the current magnitude and main features of reverse commuting, as characterized by the daily displacements of the population that resides not in the periphery but rather in the core. Flows from the metropolitan core towards the peripheral municipalities are examined using sample microdata on the MRBH municipalities from the 2000 and 2010 demographic censuses by combining the variables of "municipality of residence" and "municipality of work/study." The results indicate an increase in reverse commuting in both absolute and relative terms. When this flow is compared totraditional commuting (periphery/center), the relative values are considerable. In some cases, this relationship reaches notably high values, as the case of Confins (the municipality where the international airport is located), and also municipalities that are part of a relatively old conurbation, such as Nova Lima and Betim

As grandes cidades brasileiras, sobretudo aquelas com rápido crescimento demográfico observado a partir de meados do século passado, vêm apresentando nas últimas décadas significativos sinais de dispersão da população em suas periferias. O estudo da redistribuição espacial da população na Região Metropolitana de Belo Horizonte (RMBH) aponta para essa assertiva. Nesse processo aumentam os níveis de comutação urbana e a mobilidade pendular é um indicador relevante para aferir graus de integração no interior da metrópole. Nesse artigo avalia-se a magnitude atual e as principais características da denominada pendularidade inversa, caracterizada pelos deslocamentos diários da população residente não na periferia, mas sim no núcleo. São escrutinados os fluxos do core metropolitano em direção aos municípios periféricos. Para tanto, foram utilizados os microdados amostrais dos Censos Demográficos de 2000 e 2010 referentes aos municípios da RMBH, por meio de combinações das variáveis "município de residência" e "município de trabalho/estudo". Os resultados indicam um crescimento tanto em termos absolutos como relativo da pendularidade inversa. Quando se compara esse fluxo com a pendularidade tradicional - (periferia/centro), os valores relativos são consideráveis. Em alguns casos, essa relação atinge valores muito altos, como Confins (município onde se localiza o aeroporto internacional), ou nos municípios de conurbação relativamente antiga: Nova Lima e Betim

Las grandes ciudades de Brasil, especialmente aquellas que han experimentado un crecimiento rápido de la población desde mediados del siglo pasado, han presentado en las últimas décadas señales significativas de dispersión de la población en sus periferias. El estudio de la redistribución espacial de la población en la Región Metropolitana de Belo Horizonte (RMBH) apunta en esa dirección. En este proceso aumentan los niveles de conmutación urbana, y la movilidad pendular es un indicador relevante para estimar grados de integración dentro de la metrópoli. En este artículo se evalúan la magnitud actual y las principales características de la llamada pendularidad inversa, que se caracteriza por los desplazamientos diarios de la población residente en el centro, no en la periferia. Se examinaron los flujos desde el núcleo metropolitano hacia los municipios periféricos. Para esto, se utilizaron los microdatos muestrales de los censos emográficos de 2000 y 2010 de los municipios de la RMBH, por medio de combinaciones de las variables "municipio de residencia" y "municipio de trabajo/estudio". Los resultados revelan un aumento de la pendularidad inversa tanto en términos absolutos como relativos. Cuando se compara este flujo con la pendularidad tradicional (periferia/centro), los valores relativos son considerables. En algunos casos esta relación alcanza valores muy altos, como en Confins, municipio en el que se encuentra el aeropuerto internacional, o en los municipios de conurbación relativamente antigua, como Nueva Lima y Betim

The effect of sex and genotype on growth performance, feed efficiency, and carcass traits of local sheep group Pantaneiro and Texel or Santa Inês crossbred finished on feedlot.

This study aimed to assess and compare the growth performance, feed efficiency, and carcass traits of Pantaneiro sheep and their Texel and Santa Inês crossbreds. Ninety-six lambs, fifty-one males, and forty-five females, with a mean weaning weight of 15.21 ± 1.25 kg and 78 ± 13 days of age, were slaughtered at a 32-kg body weight. The results showed better production efficiency from males compared with females. Texel-crossed lambs had a better growth performance than the other genotypes. The Texel × Pantaneiro lambs were more efficient with a better feedlot performance, higher ribeye muscle area, and better carcass characteristics with an adequate amount of fat cover. Pantaneiro lambs and their crosses with meat breeds could be useful in meat production systems under Savanna environmental conditions.

An improved LC-MS/MS method for quantitation of indapamide in whole blood: application for a bioequivalence study.

An improved LC-MS/MS method for the quantitation of indapamide in human whole blood was developed and validated. Indapamide-d3 was used as internal standard (IS) and liquid-liquid extraction was employed for sample preparation. LC separation was performed on Synergi Polar RP-column (50 × 4.6 mm i.d.; 4 µm) and mobile phase composed of methanol and 5 mm aqueous ammonium acetate containing 1 mm formic acid (60:40), at flow rate of 1 mL/min. The run time was 3.0 min and the injection volume was 20 µL. Mass spectrometric detection was performed using electrospray ion source in negative ionization mode, using the transitions m/z 364.0 → m/z 188.9 and m/z 367.0 → m/z 188.9 for indapamide and IS, respectively. Calibration curve was constructed over the range 0.25-50 ng/mL. The method was precise and accurate, and provided recovery rates >80% for indapamide and IS. The method was applied to determine blood concentrations of indapamide in a bioequivalence study with two sustained release tablet formulations. The 90% confidence interval for the geometric mean ratios for maximum concentration was 95.78% and for the area under the concentration-time curve it was 97.91%. The tested indapamide tablets (Eurofarma Laboratórios S.A.) were bioequivalent to Natrilix®, according to the rate and extent of absorption.