RESUMO
The aim of the present study was to investigate the role of ADAMTS-7 gene in the pathogenesis of myocardial dystrophy associated with white muscle disease (WMD) in lambs. A total of 217 cardiac tissue samples from lambs with WMD were used in the study. Histopathological sections of the samples were stained with hematoxylin-eosin (HE) and examined using Western-blot, real-time PCR (RT-PCR) and immunohistochemistry for ADAMTS-7 gene expression, and the findings were statistically evaluated. Histopathological examinations revealed fibrosis associated with hyalinization, necrosis and granular calcifications in cardiomyocytes. Western blot and RT-PCR showed a statistically significant upregulation of ADAMTS-7 (p<0.05) (p<0.05). Immunohistochemical analyses showed that immunopositive cell numbers significantly high for ADAMTS-7 (p<0.05). The study has revealed that ADAMTS-7 gene is significantly expressed in myocardial dystrophy associated with WMD in addition to its role in the pathogenesis of this disease.
Assuntos
Proteína ADAMTS7/metabolismo , Cardiomiopatias/veterinária , Doença do Músculo Branco/genética , Proteína ADAMTS7/genética , Animais , Cardiomiopatias/genética , Regulação da Expressão Gênica , Predisposição Genética para Doença , HumanosAssuntos
Neoplasias Encefálicas/diagnóstico , Neoplasias do Ventrículo Cerebral/diagnóstico , Imageamento por Ressonância Magnética , Neuroblastoma/diagnóstico , Tomografia Computadorizada por Raios X , Neoplasias Encefálicas/cirurgia , Neoplasias do Ventrículo Cerebral/cirurgia , Pré-Escolar , Dominância Cerebral/fisiologia , Humanos , Ventrículos Laterais/patologia , Ventrículos Laterais/cirurgia , Masculino , Meninges/patologia , Neuroblastoma/cirurgia , Exame Neurológico , Lobo Parietal/patologia , Lobo Parietal/cirurgia , PrognósticoAssuntos
Aumento da Imagem , Imageamento por Ressonância Magnética , Tálus/patologia , Tuberculose Osteoarticular/diagnóstico , Biópsia , Doenças Ósseas Metabólicas/diagnóstico , Doenças Ósseas Metabólicas/patologia , Calcâneo/patologia , Criança , Cistos/diagnóstico , Cistos/patologia , Diagnóstico Diferencial , Feminino , Humanos , Hipertrofia , Membrana Sinovial/patologia , Ossos do Tarso/patologia , Tuberculose Osteoarticular/patologiaRESUMO
We describe a 9-year-old child with a history of trichoptysis caused by intrapulmonary teratoma and we present the CT and MRI findings of the teratoma. A heterogeneous mass containing cystic and solid elements was detected on both CT and MRI scans. Histopathological examination confirmed the diagnosis of teratoma. Teratomas arising from lung parenchyma, as in this case, are extremely rare in childhood. In the thoracic region, the most common localization of teratomas is the anterior mediastinal compartment. We also discuss the CT and MRI findings and the differential diagnosis of teratomas.
Assuntos
Cabelo/patologia , Neoplasias Pulmonares/diagnóstico , Teratoma/diagnóstico , Criança , Diagnóstico Diferencial , Humanos , Neoplasias Pulmonares/complicações , Imageamento por Ressonância Magnética , Masculino , Teratoma/complicações , Tomografia Computadorizada por Raios XRESUMO
Despite an increase in radical surgery for esophageal carcinoma, many patients continue to develop recurrent disease. Some reports have suggested that recurrent tumors should be treated aggressively with a combination of chemotherapy and radiotherapy. The aim of this study was to assess the comparative utility of computed tomography (CT) and magnetic resonance imaging (MRI) for the evaluation of recurrence after curative resection of cancer of the esophagus and gastroesophageal junction. To maximize survival benefit, detection of tumor recurrence as early and accurately as possible is important. Twenty-three patients who developed recurrent tumors after curative transthoracic esophagogastrectomy for esophageal carcinoma were analyzed retrospectively. The CT and MRI findings were correlated with pathology or with endoscopic and clinical follow-up. Primary tumor recurrence was detected at the anastomosis side in 19 patients (intraluminal mass in 13 and as diffuse or focal wall thickening in six). Distant recurrence was seen in the liver (n = 5), lung (n = 4), bone (n = 3), abdominal lymph node (n = 4), pleural effusion (n = 2) and pericardial effusion (n = 1). CT and MRI were found equal in showing the intraluminal mass, liver metastasis, pleural and pericardial effusion. Thickening of esophageal wall was demonstrated in nine patients using CT, but only seven of these tumor recurrences were confirmed by MRI, the remaining two were related to secondary fibrosis. Both CT and MRI showed diffuse gastric wall thickening determined as false tumor recurrence due to severe gastritis in one case. There were two (50%) false negatives for lung metastasis in MRI and one bone metastasis (33%) false negative in CT. CT was found superior in the demonstration of lung metastasis and MRI was superior in the evaluation of wall thickening and bone metastasis.
Assuntos
Neoplasias Esofágicas/cirurgia , Imageamento por Ressonância Magnética , Recidiva Local de Neoplasia/diagnóstico , Tomografia Computadorizada por Raios X , Adolescente , Adulto , Criança , Estudos de Coortes , Neoplasias Esofágicas/diagnóstico , Esofagectomia/métodos , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Recidiva Local de Neoplasia/mortalidade , Recidiva Local de Neoplasia/cirurgia , Estadiamento de Neoplasias , Valor Preditivo dos Testes , Probabilidade , Estudos Retrospectivos , Medição de Risco , Sensibilidade e Especificidade , Análise de SobrevidaAssuntos
Equinococose Pulmonar/epidemiologia , Adolescente , Adulto , Idoso , Cistos/diagnóstico por imagem , Cistos/epidemiologia , Equinococose Pulmonar/diagnóstico por imagem , Feminino , Humanos , Pulmão/diagnóstico por imagem , Masculino , Pessoa de Meia-Idade , Prevalência , Radiografia , Razão de Masculinidade , Turquia/epidemiologiaAssuntos
Anormalidades Múltiplas/genética , Asfixia Neonatal/genética , Aberrações Cromossômicas , Genes Recessivos , Pulmão/anormalidades , Osteocondrodisplasias/genética , Sindactilia/genética , Tórax/anormalidades , Dedos do Pé/anormalidades , Evolução Fatal , Humanos , Recém-Nascido , Masculino , Síndrome do Desconforto Respiratório do Recém-Nascido/genética , SíndromeRESUMO
Bronchogenic cysts are rare congenital anomalies located in the mediastinum and lung parenchyma. We present the clinical findings and describe the mediastinoscopic treatment of a bronchogenic cyst at the subcarinal space in a 50-year-old man. CT revealed a lesion at the subcarinal space with soft tissue density. Initially, mediastinoscopy was performed for diagnostic purposes. Histopathological evaluation of biopsy material taken from the cyst wall confirmed that the lesion was a bronchogenic cyst. The cyst contents were drained and a sclerosant agent was applied to the cyst lumen via the drainage tube. Mediastinoscopy not only provides diagnostic information but can also be used safely in the treatment of anterior bronchogenic cysts in patients not amenable to a second operation.
Assuntos
Cisto Broncogênico/cirurgia , Drenagem/métodos , Cisto Mediastínico/cirurgia , Mediastinoscopia , Cisto Broncogênico/congênito , Cisto Broncogênico/diagnóstico , Cisto Broncogênico/diagnóstico por imagem , Cisto Broncogênico/terapia , Broncoscopia , Terapia Combinada , Drenagem/instrumentação , Humanos , Masculino , Cisto Mediastínico/congênito , Cisto Mediastínico/diagnóstico , Cisto Mediastínico/diagnóstico por imagem , Cisto Mediastínico/terapia , Pessoa de Meia-Idade , Oxitetraciclina/uso terapêutico , Rifamicinas/uso terapêutico , Segurança , Soluções Esclerosantes/uso terapêutico , Escleroterapia , Tomografia Computadorizada por Raios XRESUMO
Diaphragmatic hernias are the most common abnormalities of gastrointestinal system especially in elderly patients. The radiographic findings of diaphragmatic hernias on esophagram are well known, but when incidentally found in an asymptomatic patient on axial computed tomography (CT) sections, the appearance of diaphragmatic hernia may mimic many other conditions. Our purpose is to present the CT findings of sliding hernia in an incidentally found asymptomatic patient, and to differentiate it from the other abnormalities that can be located in the distal paraesophageal area with the same appearance characteristics.
Assuntos
Neoplasias Esofágicas/diagnóstico por imagem , Hérnia Diafragmática/diagnóstico por imagem , Tomografia Computadorizada por Raios X , Diagnóstico Diferencial , Feminino , Humanos , Pessoa de Meia-IdadeRESUMO
The aim of this study was to assess the spectrum of radiographic findings in primary hyperparathyroidism (PHPT). The study group consisted of 16 women and 7 men whose Ca levels were at least two or three times higher than normal. The average age was 55.3 in women and 49.4 in men. We detected carcinoma in 1, hyperplasia in 1, multiple adenomas in 4, single adenoma in 17 patients. The most common finding in the skeletal system was the decreased bone mineral density (BMD) and the complete loss of the lamina durae dentium. BMD was found lower in women than in men. This result attributed the increased number of postmenopausal patients in our study group. The second most common finding in our study group was subperiosteal bone resorption. Brown tumors (BTs) were located at maxilla in one, widespread in one, mandibula in two, long tubular bones in four patients. Renal stone disease was found in five, spastic colon in two, gastric ulcer in one, mitral valve calcification in one patients. We demonstrated no pathologic changes consistent with PHPT in remaining seven patients.
Assuntos
Hiperparatireoidismo/diagnóstico , Adolescente , Adulto , Criança , Feminino , Humanos , Hiperparatireoidismo/sangue , Hiperparatireoidismo/diagnóstico por imagem , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Glândulas Paratireoides/diagnóstico por imagem , Tomografia Computadorizada por Raios X , Ultrassonografia DopplerAssuntos
Doenças Mamárias/complicações , Fasciite/complicações , Joelho , Idoso , Feminino , HumanosRESUMO
BACKGROUND: The purpose of the present study was to evaluate the severity of and factors related to osteopenia in children with cerebral palsy (CP). METHODS: Bone mineral density (BMD), calcium (Ca), phosphate (P), alkaline phosphatase (ALP), creatinine, parathyroid hormone (PTH) and 25-hydroxy vitamin D3 (25OHD3) concentrations were determined in 24 children with CP (15 ambulant, nine non-ambulant), aged between 10 months and 12 years (mean (+/-SD) 4.1+/-2.9 years). These vaules were compared with data obtained from a control group. RESULTS: Adjusted mean BMD values were lower in the patient group than in controls (P<0.05). However, there was no difference between BMD values of ambulant and non-ambulant patients. The Ca and P levels of the patient group were significantly higher than those of controls (P<0.05). CONCLUSIONS: The present study showed that BMD was decreased in all children with CP, but to a greater extent in non-ambulant children with CP, and immobilization is the major effective factor on bone mineralization.
Assuntos
Densidade Óssea/fisiologia , Paralisia Cerebral/fisiopatologia , Fosfatase Alcalina/sangue , Doenças Ósseas Metabólicas/etiologia , Calcifediol/sangue , Cálcio/sangue , Paralisia Cerebral/sangue , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Hormônio Paratireóideo/sangue , Fosfatos/sangueAssuntos
Dor no Peito/parasitologia , Tosse/parasitologia , Dispneia/parasitologia , Equinococose Pulmonar/complicações , Equinococose Pulmonar/diagnóstico por imagem , Adulto , Antinematódeos/uso terapêutico , Biópsia , Equinococose Pulmonar/tratamento farmacológico , Equinococose Pulmonar/patologia , Feminino , Humanos , Mebendazol/uso terapêutico , Radiografia Torácica , Tomografia Computadorizada por Raios XRESUMO
Leiomyosarcoma of the esophagus is an uncommon neoplasm of mesenchymal origin. The simultaneous occurrence of leiomyosarcoma and squamous cell carcinoma in the esophagus as separate tumors is a very rare event. We present a case leiomyosarcoma associated with squamous cell carcinoma that was diagnosed after surgical resection. The clinical, radiologic, endoscopic and pathologic findings of this rare entity, and four additional cases previously reported in the literature are reviewed.
Assuntos
Carcinoma de Células Escamosas/patologia , Neoplasias Esofágicas/patologia , Leiomiossarcoma/patologia , Neoplasias Primárias Múltiplas/patologia , Biópsia por Agulha , Carcinoma de Células Escamosas/complicações , Carcinoma de Células Escamosas/cirurgia , Neoplasias Esofágicas/cirurgia , Esofagectomia/métodos , Seguimentos , Humanos , Leiomiossarcoma/cirurgia , Masculino , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Neoplasias Primárias Múltiplas/cirurgia , Medição de Risco , Resultado do TratamentoRESUMO
The aim of this study was to assess the epidemiological and aetiological factors of male breast carcinoma in eastern Turkey. For this purpose we evaluated breast carcinoma patients admitted to our regional hospital from 1990 to 2000. A total of 196 patients were admitted during that time, 11 of whom were male (5%). The average age at presentation was 60.7 +/- 7.5. Infiltrating ductal carcinoma was the most frequent histopathological type; lobular carcinoma was detected in only one of our cases. Right-sided male breast carcinoma was seen in 7 of 11 cases, left-sided in four cases. We detected gynaecomastia in two patients. Other factors were excessive alcohol consumption for 35 years in one patient, family history in one patient and exposure to electromagnetic fields (EMFs) and light at night in four patients. We demonstrated no risk factor in the other three cases. Of the patients in our study, the youngest was 45 years old--the patient with post-pubertal gynaecomastia. The overall rate of male breast carcinoma seen among people who had worked for the Turkish Institution of Electricity in eastern Turkey was 0.3%. In our study we demonstrated a close relation between exposure to EMFs and light at night and male breast carcinoma in eastern Turkey. We also supposed that not only exposure to EMFs but also the duration of the exposure could affect the risk of development of male breast carcinoma.