Urinary hydroxypyrene and estradiol in an occupationally exposed "outdoor" population.

BACKGROUND: Polycyclic aromatic hydrocarbons (PAHs) are widely present in the air pollution. The urinary hydroxypyrene (1-HOPu) is considered the main biological biomarker currently available to measure the exposure to PAH. It is supposed responsible of an increase of estradiol levels in males. Aim of this study is to verify whether there is a relation between 1-HOPu and plasmatic estradiol in non-smoker male workers. METHODS: The study was conducted on a sample of 122 non-smoker policemen in a large Italian city; we monitored their levels of 1-HOPu and the values of estradiol. The sample was divided into three groups according to the levels of urinary hydroxypyrene. The indices of correlation (r) and multiple linear regression (ß), between levels of 1-HOPu and estradiol were calculated. It was also calculated the student's t-test among the groups to check the differences. RESULTS: We found statistically significant correlations and multivariate linear regressions between 1-HOPu and estradiol in the total sample and in group III (levels of 1-HOPu above the 75th percentile). The average levels of estradiol in group III was statistically and significantly higher than in the group I (levels of 1-HOPu below the 25th percentile) and group II (levels 1-HOPu between 25th and the 75th percentile). CONCLUSIONS: 1-HOPu in non-smoker male workers is related with an increase of plasmatic estradiol. We believe that PAHs, of which 1-HOPu is the main biomarker, can interact with the hypothalamic-pituitary axis. The preliminary results suggest that the topic needs further research on male and female as well.

[Asbestos risk: risk assessment and prevention]. / Rischio amianto: valutazione del rischio e prevenzione.

Asbestos is a very relevant medical and social issue, because of its potential dangerous effects on human health. It's present indeed in different environments, because it was widely used in the past. Asbestos is classified as first-class carcinogen, and so labelled with R 45 risk phrase. Exposure to asbestos fibers (both occupational and not) can cause diseases involving mainly the respiratory system. We point out the methods for a correct assessment of the risk from asbestos, with particular reference to current legislation and to the main preventive measures that have to be taken in case of presence of asbestos in a building. A correct prevention has to be carried out through education and information of workers and the use of specific check-lists.

[Urban stressors and thyroid hormones]. / Stressor urbani e ormoni tiroidei.

OBJECTIVES: The aim of the study is to evaluate whether occupational exposure to urban stressors could cause alterations in thyroid hormones plasma levels (TSH, FT3 and FT4) in female outdoor workers vs. administrative. MATERIALS AND METHODS: The study has been performed on an initial sample of 198 female subjects divided in two groups (occupationally exposed and not exposed to urban stressors). After excluding the subjects with the main confounding factors, female outdoor workers and administrative staff were matched by age, working life and drinking habit. RESULTS: In 40 female outdoor workers mean plasma TSH levels were significantly higher compared to 40 administrative staff. The distribution of TSH values in outdoor workers and in administrative staff was significant. Plasma FT3 and FT4 levels were not significantly different in the two groups. Our results suggest that exposure to urban stressors (chemical, physical and psycho-social), can alter the plasma concentration of TSH. CONCLUSIONS: According to our previous research, plasma TSH levels may be used as an early biological marker of chronic exposure to urban stressors, in occupational set even before the onset of the related disorders.

[Cardiovascular parameters in workers exposed to urban pollutions]. / Parametri cardiovascolari in lavoratori esposti ad inquinamento urbano.

The aim of the study is to evaluate if "outdoor" workers exposed to chemical, physical and psycho-social urban stressors could have alterations of systolic and diastolic blood pressure at rest and heart disease investigated by electrocardiogram compared with a group of "indoor" workers not exposed. Among non-smoking, the mean values of systolic blood pressure at rest were significantly higher in exposed compared to non exposed (p = 0.002) and frequency of electrocardiographic abnormalities was significantly higher in exposed (20.8%) than not exposed (10.4%, p = 0.02). Among exposed, the values of systolic blood pressure at rest were significantly higher in smokers than non-smokers (p = 0.002). Among non-exposed, the frequency of electrocardiographic abnormalities was significantly higher in smokers than non-smokers (p = 0.002). The study results suggest that chronic exposure to chemical, physical and psycho-social stressors can be a cardiovascular risk factor in addition to cigarette smoking in a manner determined by the categories of outdoor workers.

[Radon risk and prevention]. / Rischio radon e prevenzione.

The chemical element Radon is the strongest source of natural ionizing radiations for men and it is responsible of some patologies, such as lungs cancer. The concentration of this gas in houses is in Italy on average 70-75 Bq/m3. Apart from a regulative first step, represented by the 2002 Radon National Plan, at the moment there are no specified rules regarding the risks of exposition to radon in general population. On the contrary, safeguarding workers exposed to natural sources of radiation, working places are regulated by legislative decrees. In order to carry out corrective actions in case of high rates, it is necessary to correctly measure the expositional levels both with active and passive instruments. The topical knowledge about radon and its effects urge us to take preventive and reductive measures, protecting the well-being if population.