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1.
Asian Pac J Cancer Prev ; 21(6): 1559-1565, 2020 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-32592349

RESUMO

BACKGROUND: Nowadays, the adjuvant treatment for breast cancer patients chosen depends on immunohistochemical pattern of Estrogen receptor(ER), Progesterone receptor(PR) and HER2 status of primary breast tumor. Several retrospective studies showed significant discordance in receptor expression between primary and metastatic tumors. The objective of this research was to determine discordant rate of ER, PR and HER2 status between primary breast cancer and synchronous axillary lymph node metastasis of individual breast cancer patients in Thammasat University Hospital. METHODS: A prospective observational study of all breast cancer patients who have axillary metastasis and underwent surgery at Thammasat Hospital between January 2011 to December 2015. Tumor staging, ER, PR, and HER2 status on primary breast tumor were recorded. Synchronous axillary lymph node metastasis was evaluated with immunohistochemistry for ER, PR, and HER2. RESULTS: The ER-positive rate from primary tumor to synchronous axillary lymph node metastasis decreased from 74.7% to 71.7%; the HER2 overexpression rate was decreased from 26% to 24%. In contrast, PR positive rate were 71% in both primary tumor and synchronous axillary lymph node metastasis. In case to case comparison, discordance rate of ER, PR and HER2 status between primary breast cancer and synchronous axillary lymph node metastasis were 11.1%, 20.2% and 10.1%, respectively. Furthermore, the tumor staging was not significant associated with discordance of ER, PR and HER2. CONCLUSION: ER, PR and HER 2 biomarkers showed significant concordance between primary tumor and synchronous axillary lymph node metastasis. Hence, if we cannot assess the ER, PR and HER2 status in primary tumor, then synchronous axillary lymph node metastasis can be studied instead. However, the repeat of biomarker testing in node-positive breast cancer patients may be beneficial for tailored adjuvant therapy, especially for patients with negative hormone receptor and/or HER2 profile on primary tumor.


Assuntos
Neoplasias da Mama/patologia , Carcinoma Ductal de Mama/secundário , Carcinoma Lobular/secundário , Neoplasias Primárias Múltiplas/patologia , Receptor ErbB-2/metabolismo , Receptores de Estrogênio/metabolismo , Receptores de Progesterona/metabolismo , Adulto , Idoso , Idoso de 80 Anos ou mais , Axila , Neoplasias da Mama/metabolismo , Neoplasias da Mama/cirurgia , Carcinoma Ductal de Mama/metabolismo , Carcinoma Ductal de Mama/cirurgia , Carcinoma Lobular/metabolismo , Carcinoma Lobular/cirurgia , Estudos de Casos e Controles , Feminino , Seguimentos , Humanos , Metástase Linfática , Pessoa de Meia-Idade , Invasividade Neoplásica , Neoplasias Primárias Múltiplas/metabolismo , Neoplasias Primárias Múltiplas/cirurgia , Prognóstico , Estudos Prospectivos , Taxa de Sobrevida , Adulto Jovem
2.
J Med Assoc Thai ; 99 Suppl 4: S42-7, 2016 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-29916677

RESUMO

Background: Endoscopic thyroidectomy has increased in popularity because of the good cosmesis. In Thailand, most endoscopic thyroidectomy surgeries are done with a gas technique, using CO2 insufflation to obtain a working space. The CO2 pressure has to be kept under control to prevent gas-related complications. In contrast, there are no such complications in video assisted neck surgery (VANS), a gasless technique. The VANS technique could be an option of endoscopic thyroidectomy in Thailand. Objective: This study reports the outcome of the initial experience of using gasless endoscopic thyroidectomy (VANS technique) in Thailand. Material and Method: From July to October 2015, five patients underwent thyroidectomy with the VANS technique at Thammasat University Hospital. Patient selection criteria consisted of non-malignant nodule diagnosed by FNA, nodule size <4 cm, no previous neck surgery and no neck irradiation. Results: All five patients successfully underwent endoscopic thyroid lobectomy with the VANS technique. The mean operating time was 152 minutes and mean blood loss was 34 ml. There were no serious complications, and the patients were satisfied with the cosmetic outcomes. Pathologic results were nodular goiter in four cases and adenomatous goiter with occult papillary microcarcinoma in one case (in this case, the margins were free of malignancy). Conclusion: The VANS technique is feasible and safe to be used in Thailand.


Assuntos
Pescoço/cirurgia , Nódulo da Glândula Tireoide/cirurgia , Cirurgia Vídeoassistida/métodos , Adulto , Endoscopia/métodos , Feminino , Bócio Nodular/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Duração da Cirurgia , Tailândia , Neoplasias da Glândula Tireoide/cirurgia , Tireoidectomia/métodos
3.
Oncol Lett ; 4(1): 67-70, 2012 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-22807962

RESUMO

Ewing's sarcoma/primitive neuroectodermal tumour (ES/PNET) is a rare tumour usually detected in young individuals and uncommonly found within the breast tissue. In this case report, we examined a 46-year-old patient, who developed a lump on her breast and was later diagnosed with ES/PNET. Clinical presentation, age at development and radiological findings were of interest and were discussed. Diagnosis of the tumour was confirmed using various immunohistochemical studies and the presence of a translocation, t(11;22). A literature review of this rare condition was also included.

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