Assuntos
Dermatomiosite , Doenças Pulmonares Intersticiais , Humanos , Dermatomiosite/complicações , Dermatomiosite/tratamento farmacológico , Doenças Pulmonares Intersticiais/complicações , Doenças Pulmonares Intersticiais/tratamento farmacológico , Progressão da Doença , Autoanticorpos , Helicase IFIH1 Induzida por Interferon , Estudos Retrospectivos , PrognósticoRESUMO
Neutrophilic dermatoses (ND) are inflammatory skin conditions characterized by a sterile infiltrate of normal polymorphonuclear leukocytes. The main clinical forms of ND include Sweet syndrome, pyoderma gangrenosum, erythema elevatum diutinum, subcorneal pustular dermatosis, and their atypical or transitional forms. ND are often idiopathic, but they may be associated with myeloid hematologic malignancies (Sweet syndrome), inflammatory bowel disease or rheumatoid arthritis (pyoderma gangrenosum), and monoclonal gammopathies (erythema elevatum diutinum, subcorneal pustular dermatosis). The possible infiltration of internal organs with neutrophils during the setting of ND underlies the concept of a neutrophilic systemic disease. ND may be seen as a polygenic autoinflammatory syndrome due to their frequent association with other autoinflammatory disorders (monogenic or polygenic) and the recent published efficacy of interleukin-1 blocking therapies in their management.
Assuntos
Doenças Musculoesqueléticas/complicações , Neutrófilos , Pioderma Gangrenoso/complicações , Síndrome de Sweet/complicações , Doenças Hematológicas/complicações , Humanos , Doenças Inflamatórias Intestinais/complicações , Pneumopatias/complicações , Pioderma Gangrenoso/patologia , Dermatopatias Vesiculobolhosas/patologia , Síndrome de Sweet/patologia , Vasculite Leucocitoclástica Cutânea/complicações , Vasculite Leucocitoclástica Cutânea/patologiaRESUMO
We report the case of a man with a seven year history of lung adenocarcinoma who was diagnosed with cutaneous lymphangitis carcinomatosa. Skin examination revealed both an asymptomatic erysepelatoid rash localized on the posterior chest and an erythematous, eczematiform, itchy rash on the right anterior chest and on the left shoulder. Histopathologic examination of biopsies of these lesions revealed the same aspect with an infiltration of the dermal lymphatics by metastatic adenocarcinomatous cells. Cutaneous lymphangitis carcinomatosa is a rare condition accounting for less than 5% of skin metastases. A literature review identified eight other cases of cutaneous lymphangitis carcinomatosa in patients with lung cancer.