[Clinical evaluation of the effectiveness of cholinesterase inhibition with neuromidin in the treatment of primary glaucoma patients]. / Klinicheskaia otsenka éffektivnosti ingibitora kholinésterazy neĭromedina v lechenii bol'nykh s pervichnoĭ glaukomoĭ.

AIM: to investigate neuromidin effectiveness in the treatment of patients with primary glaucoma and compensated intraocular pressure (IOP). MATERIAL AND METHODS: A total of 40 patients (80 eyes) were examined. Of them, 10 eyes with early glaucoma, 36 eyes with moderate-stage glaucoma, 33 eyes with advanced glaucoma, and 1 eye with end-stage glaucoma. In 19 eyes, IOP was controlled through beta-blockers, in 11 eyes - through carbonic anhydrase inhibitors, in 10 eyes - through prostaglandin analogues, and in 39 eyes - through combination drugs. Twenty-six eyes had received glaucoma surgery some time earlier. Ipidacrine was prescribed in tablets at 20 mg 2 times daily for 25 days. Treatment effectiveness was judged by visual functions, hydrodynamics, and morphometric parameters of the optic disc. RESULTS: In moderate-stage eyes, visual acuity improved in 66.6% of cases and remained unchanged in 33.3%. In advanced-stage eyes, visual acuity improved in 51.5% of cases and remained unchanged in 48.5%. Visual field broadened in all cases. Moreover, under the neuromidin therapy, the number of scotomas in early-stage eyes decreased, while the number of areas with normal sensitivity of the retina increased by 14.9%. In advanced-stage glaucoma, the effect was less pronounced: the number of type 1 and type 2 scotomas decreased by 3.0±0.6% and 2.9±0.8%, respectively; the number of absolute scotomas did not change; the number of areas with normal sensitivity of the retina increased by 7.4±2.0%. Also, P0 was found to be reduced and intraocular fluid outflow - activated. In early and moderate glaucoma, there was a significant reduction in the cup area as well as an increase in the neuroretinal rim area and retinal nerve fiber layer thickness. In advanced-stage cases, it was only the retinal nerve fiber layer thickness that changed. CONCLUSION: Neuromidin has a positive impact on visual function, hydrodynamics, and morphometric parameters of the optic disc.

[Clinical evaluation of the effectiveness of combined use of local and general hypotensive agents in patients with glaucoma and hypertension]. / Klinicheskaia otsenka éffektivnosti sochetannogo primeneniia mestnykh i obshchikh gipotenzivnykh sredstv u bol'nykh pervichnoi glaukomoi s gipertonicheskoi bolezn'iu.

Visual functions, hydrodynamics, and bloodflow in internal carotid arteries were evaluated in 60 patients with primary glaucoma and essential hypertension. Effects of systemic and local beta-adrenoblockers and combinations of local hypotensive agents with calcium antagonists and angiotensin-converting enzyme inhibitors were studied. Negative effect of a combination of local and oral beta-adrenoblockers and positive effect of a combination of local hypotensive agents with oral capotene were revealed. Capotene is recommended for the treatment of glaucomatous patients with essential hypertension.