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PURPOSE: Elective open incisional hernia operations are a frequently performed and complex procedure. Prophylactic drainage is widely practised to prevent local complications, but nevertheless the benefit of surgical drain placement remains a controversially discussed subject. Objective of this analysis was to evaluate the current status of patient care in clinical routine and outcome in this regard. METHODS: The study based on prospectively collected data of the Herniamed Register. Included were all patients with elective open incisional hernia between 1/2005 and 12/2020 and completed 1-year follow-up. Multiple linear and logistic regression analysis was performed to assess the relation of individual factors to the outcome variables. RESULTS: Analysed were data from 39,523 patients (28,182 with drain, 11,341 without). Patients with drain placement were significantly older, had a higher BMI, more preoperative risk factors, and a larger defect size. Drained patients furthermore showed a significant disadvantage in the outcome parameters intraoperative complications, general complications, postoperative complications, complication-related reoperations, and pain at the 1-year follow-up. No significant difference was observed with respect to the recurrent rate. CONCLUSION: With 71.3%, the use of surgical drainages has a high level of acceptance in elective open incisional hernia operations. The worse outcome of patients is associated with the use of drains, independent of other influencing factors in the model such as patient or surgical characteristics. The use of drains may be a surrogate parameter for other unobserved confounders.
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INTRODUCTION: Median arcuate ligament syndrome has been known anatomically for approximately 100 years and results from a compression of the coeliac axis by fibrous attachment of the diaphragmatic crura. Owing to the rarity of the disease and limited available data, many aspects of treatment are controversial. Currently, laparoscopic decompression is considered by several authors as standard surgical procedure. We present an analysis of the clinical routine of MALS therapy. METHODS: We conducted a prospective observational trial in patients with MALS between March 2016 and August 2018, in which clinical symptoms, diagnostic evaluation, procedures with complication analysis and follow-up data were recorded. RESULTS: A total of 18 patients (12 female, 6 male) with MALS, aged between 15 and 65 years, were included in this study. All patients presented with long-standing abdominal pain. Preoperative Doppler ultrasonography showed a flow velocity of the coeliac artery averaging 289.9cm/second in mid-position of the diaphragm, 285.9cm/second in expiration and 199.0cm/second in inspiration. All operated patients underwent laparoscopic decompression; two patients received an angiographic intervention. Postoperatively, a significant decrease of the flow velocity in mid-position of the diaphragm was detected (P = 0.018). At follow-up after 5.2 months, 50.0% of the patients were pain-free, 37.5% reported symptomatic relief and 12.5% showed evidence for a recurrence. CONCLUSION: MALS is challenging both diagnostically and therapeutically. Laparoscopy with release of the median arcuate ligament is an essential part of the therapy and can be confirmed by Doppler ultrasonography. Disease outcome is also influenced by several predictive factors.
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Artéria Celíaca/cirurgia , Síndrome do Ligamento Arqueado Mediano/cirurgia , Dor Abdominal/diagnóstico por imagem , Dor Abdominal/etiologia , Adolescente , Adulto , Idoso , Velocidade do Fluxo Sanguíneo , Artéria Celíaca/diagnóstico por imagem , Artéria Celíaca/fisiopatologia , Descompressão Cirúrgica/efeitos adversos , Descompressão Cirúrgica/métodos , Feminino , Seguimentos , Humanos , Laparoscopia/efeitos adversos , Laparoscopia/métodos , Masculino , Síndrome do Ligamento Arqueado Mediano/complicações , Síndrome do Ligamento Arqueado Mediano/diagnóstico por imagem , Pessoa de Meia-Idade , Resultado do Tratamento , Ultrassonografia Doppler/métodos , Adulto JovemRESUMO
INTRODUCTION: Since its first publication in 1997, minimally invasive video-assisted thyroidectomy (MIVAT) has developed into the predominant minimally invasive surgery of the thyroid. A major advantage over conventional thyroid surgery is the superior cosmetic result. However, there are still few data comparing the long-term cosmetic results of the two methods. This paper compares the long-term cosmetic results of the two methods, based on follow-up assessments. METHODS: Between 2004 and 2011, 143 preselected patients underwent a MIVAT in our department. Additionally, 134 patients underwent a conventional thyroidectomy in our hospital in 2011. A total of 117 patients from the MIVAT group and 102 patients from the conventional thyroidectomy group received follow-up assessments after 23.1 and 23.6 months, respectively, using the patient and observer scar assessment scale. RESULTS: The measurable cervical scar length averaged 1.9 cm in the MIVAT group and 3.9 cm in the conventional group (P < 0.001). Some 11.1% of the patients in the MIVAT group and 7.1% of the patients in the conventional group had developed keloid (P = 0.391). The patient scar assessment score was 10.4 for the MIVAT group compared with 9.9 for the conventional thyroidectomy group (P = 0.691) and the observer scare assessment score was 8.6 for MIVAT compared with 9.9 for conventional thyroidectomy (P = 0.011). CONCLUSION: In the patient assessment instrument, conventional thyroidectomy had a small advantage over MIVAT in the cosmetic long-term results. This difference between the two groups was, however, not significant. Our result contradicts short-term cosmetic results of published randomized studies with improvement for MIVAT. The Observer Score demonstrates a significant advantage of the MIVAT.
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Cicatriz/diagnóstico , Estética , Avaliação de Resultados da Assistência ao Paciente , Doenças da Glândula Tireoide/cirurgia , Tireoidectomia/efeitos adversos , Cirurgia Vídeoassistida/efeitos adversos , Adulto , Idoso , Idoso de 80 Anos ou mais , Cicatriz/etiologia , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Glândula Tireoide , Tireoidectomia/métodos , Fatores de Tempo , Resultado do Tratamento , Cirurgia Vídeoassistida/métodos , Adulto JovemRESUMO
Colon carcinomas are the most common malignant tumours in the Western world. Important findings about the overall quality of medical care have been reported in multi-centre observational studies. A quality enhancement of therapeutic care can be achieved by an additional increase in diagnostic and therapeutic measures in the interdisciplinary setting. The development of colon cancer centres improves the chance to objectively observe the results of medical care induced by the development of an interdisciplinary and cross-sectoral unit that includes a comprehensive medical care for patients. The implementation of the current medical findings based on evidence in clinical routine, the inspection of the usage of guidelines by external specialists as part of an audit and the continuous correction of analysed deficits in the course of treatment guarantee a continuous improvement of service.
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Institutos de Câncer/organização & administração , Institutos de Câncer/normas , Neoplasias Colorretais/cirurgia , Cirurgia Colorretal/organização & administração , Cirurgia Colorretal/normas , Certificação/organização & administração , Certificação/normas , Neoplasias Colorretais/diagnóstico , Neoplasias Colorretais/mortalidade , Assistência Integral à Saúde/organização & administração , Assistência Integral à Saúde/normas , Comportamento Cooperativo , Comparação Transcultural , Intervalo Livre de Doença , Medicina Baseada em Evidências , Feminino , Alemanha , Fidelidade a Diretrizes , Humanos , Comunicação Interdisciplinar , Masculino , Auditoria Médica , Avaliação de Resultados em Cuidados de Saúde/organização & administração , Avaliação de Resultados em Cuidados de Saúde/normas , Avaliação de Processos e Resultados em Cuidados de Saúde/organização & administração , Avaliação de Processos e Resultados em Cuidados de Saúde/normas , Equipe de Assistência ao Paciente/organização & administração , Equipe de Assistência ao Paciente/normas , Melhoria de Qualidade/organização & administração , Melhoria de Qualidade/normasAssuntos
Carcinoma de Células em Anel de Sinete/patologia , Doença de Crohn/patologia , Neoplasias do Íleo/patologia , Laparoscopia , Adulto , Anastomose Cirúrgica , Azatioprina/administração & dosagem , Azatioprina/efeitos adversos , Carcinoma de Células em Anel de Sinete/induzido quimicamente , Carcinoma de Células em Anel de Sinete/cirurgia , Transformação Celular Neoplásica/efeitos dos fármacos , Transformação Celular Neoplásica/patologia , Colectomia , Colo/patologia , Colo/cirurgia , Doença de Crohn/tratamento farmacológico , Doença de Crohn/cirurgia , Feminino , Humanos , Neoplasias do Íleo/induzido quimicamente , Neoplasias do Íleo/cirurgia , Íleo/patologia , Íleo/cirurgia , Invasividade Neoplásica , Estadiamento de Neoplasias , Bexiga Urinária/patologiaRESUMO
INTRODUCTION: With about 135,000 operations every year appendectomy is one of the most frequent surgical operations in Germany. Acute appendicitis has shown changes in diagnosis and therapy with time. The status of the laparoscopic appendectomy has had to be redefined recently. The aim of this study was to make an analysis of the current surgical therapy for appendicitis and the individual procedures. PATIENTS AND METHODS: Three prospective multi-centre quality assurance studies (1988 /â89, 1996 /â97; 2008 /â09) of the "An-Institut" acquired 17,732âtreatments from all supply levels of Germany. RESULTS: The average age of patients increased within of the three studies from 25.7 to 34.6âyears. Within the studies in 1996 /â97 and in 2008 /â09 the share of laparoscopic appendectomy advanced from 33.1 to 85.8âpercent. In the study from 2008 /â09 the laparoscopic appendectomy showed a significant advantage over the conventional technique in terms of wound-healing disturbances (pâ< 0.001) and a clinical duration of stay (pâ< 0.001). At no stage of the appendix inflammation did the laparoscopic appendectomy lead to a significant increase of intraabdominal abscesses. Compared with the conventional technique the operating time was shorter (46.6 min vs. 53.5 min). Currently the use of a stapler is the mostly frequently applied method of appendiceal stump closure (83.6âpercent). CONCLUSION: The laparoscopic appendectomy is the most common method of current operative therapy. In comparison to former publications, there is no proof of any disadvantages of laparoscopic appendectomy.
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Apendicectomia , Apendicite/cirurgia , Pesquisa sobre Serviços de Saúde , Laparoscopia , Complicações Pós-Operatórias/etiologia , Adulto , Fatores Etários , Apendicectomia/estatística & dados numéricos , Apendicite/diagnóstico , Apendicite/epidemiologia , Estudos Transversais , Feminino , Alemanha , Humanos , Laparoscopia/estatística & dados numéricos , Tempo de Internação/estatística & dados numéricos , Masculino , Complicações Pós-Operatórias/epidemiologia , Estudos Prospectivos , Garantia da Qualidade dos Cuidados de Saúde , Fatores Sexuais , Grampeamento Cirúrgico/estatística & dados numéricos , Ultrassonografia/estatística & dados numéricos , CicatrizaçãoRESUMO
Within the last decade, intramedullary nailing systems have gained enormous popularity in the treatment of fractures of the trochanteric region. However, these implants are not free of any complications. Commonly reported treatment failures include stress-derived femur fracture, rotational displacement, varus deformity of the femoral neck and head, and implant cutout through the femoral neck. So far, there are only five cases known in the literature describing dislocation of the medial leg screw into the pelvis. The patient history, operative intervention, and course are reported. The incidence of such cases is discussed. Modifications of intramedullary nailing systems are mentioned.
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Parafusos Ósseos/efeitos adversos , Fixação Intramedular de Fraturas/efeitos adversos , Fraturas Ósseas/etiologia , Ossos Pélvicos/lesões , Falha de Prótese , Idoso de 80 Anos ou mais , Fraturas Ósseas/diagnóstico por imagem , Humanos , Masculino , Ossos Pélvicos/diagnóstico por imagem , RadiografiaAssuntos
Artéria Celíaca/cirurgia , Isquemia/cirurgia , Laparoscopia/métodos , Estômago/irrigação sanguínea , Adulto , Angiografia Digital , Aorta Abdominal/cirurgia , Velocidade do Fluxo Sanguíneo/fisiologia , Constrição Patológica/diagnóstico , Constrição Patológica/cirurgia , Diagnóstico Diferencial , Expiração/fisiologia , Seguimentos , Gastroscopia , Humanos , Inalação/fisiologia , Isquemia/diagnóstico , Ligamentos/cirurgia , Masculino , Microcirurgia/métodos , Complicações Pós-Operatórias/diagnóstico , Recidiva , Síndrome , Tomografia Computadorizada por Raios X , Ultrassonografia Doppler em CoresAssuntos
Dor Abdominal/etiologia , Dor Abdominal/cirurgia , Apendicectomia , Íleo/irrigação sanguínea , Achados Incidentais , Isquemia/diagnóstico , Laparoscopia , Papulose Atrófica Maligna/diagnóstico , Omento/irrigação sanguínea , Pele/irrigação sanguínea , Adulto , Biópsia , Diagnóstico Diferencial , Humanos , Íleo/patologia , Isquemia/patologia , Masculino , Papulose Atrófica Maligna/patologia , Mesentério/irrigação sanguínea , Mesentério/patologia , Músculo Liso Vascular , Omento/patologia , Pele/patologiaRESUMO
Appendicitis is the most common cause of an -acute abdomen. Around 135 000 patients undergo appendectomy in Germany every year. Acute -appendicitis shows changes in epidemiology, -diagnosis and therapy. Epidemiological data indicate a continuing decrease in the incidence of acute non-perforated appendicitis. The incidence of perforated appendicitis has remained constant despite laparoscopy and imaging diagnostics. The status of sonography and CT scanning is increasing in the diagnosis of appendicitis. But there are differences between the sensitivity and specifity of study results and the clinical routine. The in-crease of imaging diagnostics does not correlate with a decrease in the incidence of perforated -appendicitis. Laparoscopic appendectomy has -developed as a dominant method for operative therapy. There is no proof of a higher rate of postoperative intraabdominal abscesses any more. The use of a stapler is mostly required for appendical stump closure.
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Abdome Agudo/epidemiologia , Abdome Agudo/cirurgia , Apendicectomia/estatística & dados numéricos , Apendicite/epidemiologia , Apendicite/cirurgia , Abscesso Abdominal/epidemiologia , Adolescente , Fatores Etários , Apendicite/diagnóstico , Criança , Estudos Transversais , Alemanha , Humanos , Incidência , Laparoscopia/estatística & dados numéricos , Imageamento por Ressonância Magnética , Complicações Pós-Operatórias/epidemiologia , Fatores Sexuais , Tomografia Computadorizada por Raios X , Ultrassonografia , Revisão da Utilização de Recursos de Saúde/estatística & dados numéricos , Adulto JovemRESUMO
BACKGROUND: In human acute pancreatitis (AP) the local anaesthetic procainhydrochloride (procain-HCl) is given intravenously for pain treatment. Procain has been shown to inhibit catalytic activity of pancreatic (group I) phospholipase A2 (PLA2) and non-pancreatic (group II) PLA2. Both enzymes are important mediators for the local and systemic inflammatory process in AP. To determine the effect of procain, we examined serum and tissue levels of both types of PLA2 activity in the experimental rodent taurocholate model of AP. METHODS: In 60 rats, severe pancreatitis was induced by taurocholate. Forty rats were treated with procain-HCl intravenously at a dosage of 2 mg/kg body weight/h either at or 1 h after induction of pancreatitis. Twenty rats served as controls. We measured catalytic activities of group I and group II PLA2 in serum and tissue samples of lung and pancreas. RESULTS: Serum group II PLA2 catalytic activity was significantly reduced 3 and 6 h after AP induction in rats treated with procain-HCl (p < 0.001) in both treatment groups. In pancreatic and lung tissue, group II PLA2 catalytic activity was significantly reduced compared with normal values (p < 0.001). CONCLUSION: Procain-HCl given intravenously either at or 1 h after induction of necrotizing pancreatitis significantly inhibits group II PLA2 catalytic activity in serum and tissues.
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Biocatálise/efeitos dos fármacos , Pancreatite/tratamento farmacológico , Pancreatite/enzimologia , Fosfolipases A2/metabolismo , Procaína/farmacologia , Procaína/uso terapêutico , Animais , Fosfolipases A2 do Grupo II/sangue , Pulmão/efeitos dos fármacos , Pulmão/enzimologia , Masculino , Pancreatite/sangue , Pancreatite/induzido quimicamente , Fosfolipases A2/sangue , Ratos , Ratos Wistar , Ácido TaurocólicoRESUMO
BACKGROUND: We report on a new method of incisional hernia repair applicable to any size of hernia and the long-term results of this method. Musculus rectus abdominis is bandaged or partially bandaged in a loose way with a 2-cm-wide band of polypropylene (Prolene) on both sides at a distance of 2 cm, depending on the size of the hernial opening. The aims of this technique, which were defined in 1999 when we started using the method, were to find a simple method for surgeons, a safe mesh fixation and the prevention of a postoperative stiff abdomen. Another aim was to find a method for optimal patient care at reasonable costs. METHODS: Two hundred and seventeen patients underwent an operation according to this method in our department from June 1999 until December 2007. The first 75 patients of this cohort were treated using a technique in which the musculus rectus abdominis was bandaged in a loose way. One hundred and forty-two patients (since October 2001) were treated using a technique in which the muscle was not entirely bandaged. Instead, the polypropylene bands, which had been placed in sublay position, were penetrating the lateral rim through incisions and were fastened there. We included 124 patients (October 2001 to December 2006) in our further examination with a follow-up of 17-79 months. RESULTS: We found a recurrence rate of 6%, 80.1% of the patients had no trouble, 18.1% of the patients had very rarely any complaint, 0.9% of the patients had problems after exercise and 0.9% had permanent problems. All patients had excellent mobility of the abdomen. CONCLUSION: This method was proven to give good results in the long run and can be easily learned by any surgeon. This method is a true alternative to all methods which have been published so far.
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Hérnia Ventral/cirurgia , Reto do Abdome/cirurgia , Procedimentos Cirúrgicos Operatórios/métodos , Adulto , Idoso , Idoso de 80 Anos ou mais , Materiais Biocompatíveis , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Polipropilenos , Próteses e ImplantesRESUMO
Cystic tumor lesions of the pancreas are relatively uncommon. Advances in imaging and pathohistology, including immunohistochemistry, have led to the detection and classification of novel tumor entities. A promoting aspect is the extended indication profile in pancreatic surgery, in particular, because of lower perioperative morbidity and mortality. One of these classified cystic neoplasms of the pancreas is serous oligocystic adenoma (SOIA), a rare and benign tumor lesion. We report on a 41-year-old man with a cystic lesion within the pancreatic head. Therefore, he underwent pylorus-preserving cephal duodenopancreatectomy. Pathohistologic investigation revealed a SOIA. He had a medical history significant for subtotal colectomy because of a synchronous double colonic carcinoma. Both tumor tissue specimens had been characterized for a high level of microsatellite instability (MSI) and loss of hMLH1, as well as for a corresponding germ line mutation in hMLH1 gene, leading to the diagnosis of hereditary non-polyposis associated colon cancer (HNPCC). The case is remarkable since the SOIA revealed MSI and loss of hMLH1 protein in the tumor cells that has never been reported for this tumor type. In addition, there is a rare and extraordinary association between SOIA and HNPCC, which has never been published before, since SOIA, in this case, could have been developed in the setting of HNPCC syndrome.
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Neoplasias Colorretais Hereditárias sem Polipose/genética , Cistadenoma/genética , Neoplasias Pancreáticas/genética , Adulto , Cistadenoma/metabolismo , Cistadenoma/cirurgia , Reparo do DNA , Humanos , Imuno-Histoquímica , Masculino , Instabilidade de Microssatélites , Proteína 2 Homóloga a MutS/metabolismo , Neoplasias Pancreáticas/metabolismo , Neoplasias Pancreáticas/cirurgia , Resultado do TratamentoRESUMO
Loss of the coxsackie and adenovirus receptor (CAR) has previously been observed in gastric cancer. The role of CAR in gastric cancer pathobiology, however, is unclear. We therefore analysed CAR in 196 R(0)-resected gastric adenocarcinomas and non-cancerous gastric mucosa samples using immunohistochemistry and immunofluorescence. Coxsackie and adenovirus receptor was found at the surface and foveolar epithelium of all non-neoplastic gastric mucosa samples (n=175), whereas only 56% of gastric cancer specimens showed CAR positivity (P<0.0001). Loss of CAR correlated significantly with decreased differentiation, increased infiltrative depths, presence of distant metastases, and was also associated with reduced carcinoma-specific survival. To clarify whether CAR impacts the tumorbiologic properties of gastric cancer, we subsequently determined the role of CAR in proliferation, migration, and invasion of gastric cancer cell lines by application of specific CAR siRNA or ectopic expression of a human full-length CAR cDNA. These experiments showed that RNAi-mediated CAR knock down resulted in increased proliferation, migration, and invasion of gastric cancer cell lines, whereas enforced ectopic CAR expression led to opposite effects. We conclude that the association of reduced presence of CAR in more severe disease states, together with our findings in gastric cancer cell lines, suggests that CAR functionally contributes to gastric cancer pathogenesis, showing features of a tumour suppressor.
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Adenocarcinoma/metabolismo , Regulação Neoplásica da Expressão Gênica , Receptores Virais/metabolismo , Neoplasias Gástricas/metabolismo , Adenocarcinoma/secundário , Adenoviridae/fisiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Western Blotting , Movimento Celular , Proliferação de Células , Proteína de Membrana Semelhante a Receptor de Coxsackie e Adenovirus , Enterovirus/fisiologia , Feminino , Imunofluorescência , Mucosa Gástrica , Humanos , Técnicas Imunoenzimáticas , Metástase Linfática , Masculino , Pessoa de Meia-Idade , Invasividade Neoplásica , Prognóstico , RNA Mensageiro/genética , RNA Mensageiro/metabolismo , Receptores Virais/genética , Reação em Cadeia da Polimerase Via Transcriptase Reversa , Neoplasias Gástricas/patologia , Análise Serial de Tecidos , Transfecção , Células Tumorais CultivadasRESUMO
MATERIAL AND METHODS: All surgical departments in Saxony-Anhalt, Saxony and Thuringia were included in the study. Two questionnaires were administered. One was directed at the chairmen of departments and the other at residents. An additional questionnaire was administered to foreign residents. RESULTS: A total of 58 chairmen of surgical departments, who maintain 270 training positions and 100 residents with 22 (22%) being foreigners, participated in the study. Twenty resident positions (7.4%) were unfilled, 27 (27%) residents saw their professional future abroad and 46 (46%) were generally satisfied with their surgical records while three (3%) were satisfied with the documentation procedures. A total of 28 (28%) were content with the amount of free time but 7 (31.8%) foreign residents regretted their decision to come to Germany. CONCLUSION: The decline in the number of physicians in central Germany is serious. The situation is caused by insufficient salary, unrecorded and unpaid overtime, an unacceptable amount of leisure time and an insufficient guarantee for the amount surgical procedures provided.
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Cirurgia Geral/educação , Internato e Residência , Atitude do Pessoal de Saúde , Escolha da Profissão , Coleta de Dados , Médicos Graduados Estrangeiros/estatística & dados numéricos , Alemanha , Humanos , Satisfação no Emprego , Recursos Humanos , Carga de Trabalho/estatística & dados numéricosRESUMO
BACKGROUND: Surgery, as well as conservative treatment, in patients with clinically apparent intrathoracic anastomotic leaks are often associated with poor results and carry a high morbidity and mortality. This report describes our results with the endoscopic treatment of intrathoracic anastomotic leakages. PATIENTS: 27 consecutive patients presenting with clinically apparent intrathoracic anastomotic leak, caused by resection of an epiphrenic diverticulum (n=1), esophagectomy for esophageal cancer (n=19), limited resection for carcinoma of the gastroesophageal junction (n=1) or gastrectomy for gastric cancer (n=6) were endoscopically treated. The extent of the dehiscences ranged from about 10-70%. After endoscopic lavage and debridement of the leakage (mean duration: 16,8 days) the leaks were closed with fibrin clue (n=9) or endoclips (n=2) in cases of smaller leaks or by stent placement (n=11), stent placement after unsuccessful fibrin clue injections (n=3) or stent placement and endoclipping (n=1) in patients with a large leakage. Simultaneously the periesophageal mediastinum was drained by chest drains. RESULTS: 25 of 27 patients were successfully treated endoscopically. Under endoscopic treatment one patient died due to septic multiorgan failure. Another patient developed a refractory, persistent leak. Procedure related complications (stent migration, anastomotic stenosis) were obtained in 6 patients. CONCLUSION: An endoscopic approach is successful and safe to treat symptomatic intrathoracic anastomotic leaks smaller than 70% of the circumference. An endoscopic lavage and debridement of the leak, prior to leak closure, seems to be helpful to reduce mediastinal and pleural inflammation. In patients with smaller leaks (<30%) fibrin clue injections and endoclipping is recommended. Patients with a dehiscence from 30-70% of the circumference profit from stent placement.
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Anastomose Cirúrgica/efeitos adversos , Endoscopia , Adulto , Idoso , Idoso de 80 Anos ou mais , Desbridamento , Divertículo Esofágico/cirurgia , Neoplasias Esofágicas/cirurgia , Esofagectomia , Junção Esofagogástrica , Feminino , Adesivo Tecidual de Fibrina , Gastrectomia , Humanos , Masculino , Mediastino , Pessoa de Meia-Idade , Stents , Neoplasias Gástricas/cirurgia , Deiscência da Ferida Operatória/cirurgia , Irrigação Terapêutica , Resultado do TratamentoRESUMO
BACKGROUND: As angiogenesis is one of the key steps in tumor growth, invasion, and metastasis, antiangiogenic therapy is supposed to be an attractive approach for antitumor treatment. We investigated the cytotoxic, anti-adhesive, and anti-invasive effects of angiostatin in vitro and on intraperitoneal tumor growth in a laparoscopic rat model of peritoneal carcinomatosis using CC531 colon adenocarcinoma cells. METHODS: The in vitro adhesion and cytotoxicity assays were performed with microtiter plates, and the invasion assay with Transwell dual chambers. Normal saline was used as control. In in vivo experiments, CC531 adenocarcinoma cells were intraperitoneally given to Wistar Albino Glaxo rats after the establishment of a pneumoperitoneum. The animals received angiostatin in different doses intraperitoneally, and in some, angiostatin was additionally administered subcutaneously. Saline was used as control. After 21 days, the animals were euthanized to determine the intra-abdominal tumor weight. RESULTS: In in vitro experiments, there was no effect of angiostatin on the viability of tumor cells in the cytotoxicity assay, but there was a significant inhibition of tumor cell adhesion and invasion (p<0.05 and p<0.01) in all angiostatin concentrations. In in vivo experiments, an intraperitoneal application of 20 microg angiostatin, but not 10 microg, significantly (p<0.005) decreased the intraperitoneal tumor weight compared with controls. This effect was most pronounced after the combined intraperitoneal and subcutaneous applications. CONCLUSION: Angiostatin given intraperitoneally at a dose of 20 microg alone or in combination with subcutaneous application significantly diminishes intraperitoneal tumor growth in rats undergoing laparoscopy. This may offer additional therapeutic options for patients undergoing laparoscopic surgery for colorectal cancer.
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Inibidores da Angiogênese/farmacologia , Angiostatinas/farmacologia , Neovascularização Patológica/prevenção & controle , Neoplasias Peritoneais/patologia , Adenocarcinoma/patologia , Animais , Adesão Celular/efeitos dos fármacos , Linhagem Celular Tumoral/efeitos dos fármacos , Neoplasias do Colo/patologia , Modelos Animais de Doenças , Relação Dose-Resposta a Droga , Injeções Intraperitoneais , Injeções Subcutâneas , Laparoscopia , Masculino , Transplante de Neoplasias , Neoplasias Peritoneais/irrigação sanguínea , Pneumoperitônio Artificial , Distribuição Aleatória , Ratos , Ratos WistarRESUMO
BACKGROUND: Endoscopic and laparoscopic local resection of gastric tumors has increasingly been performed in recent years. This article describes the technical considerations and early results of laparoscopic-endoscopic rendezvous resection of gastric lesions. PATIENTS AND METHODS: Rendezvous resection was performed in 26 patients with submucosal gastric tumors (n = 22) and early gastric cancer (n = 4). Laparoscopic wedge resection (LWR) was performed in 16 patients with anterior wall tumors and laparoscopic intragastric resection (LIR) in 7 patients with posterior wall tumors. Conversion to open surgery was carried out in 3 cases. RESULTS: Operation times were 53 min (range 35-115) for LWR and 83 min (range 56-130) for LIR, respectively. In submucosal lesions the mean tumor size was 36 mm (range 16-47) and in early gastric cancer 17.3 mm (range 16-20). Rendezvous resection was performed with curative intent and clear resection margins in all patients without lymphatic or vessel permeation. Postoperative complications occurred in 2 patients. After a mean follow-up of 22.8 months (range 2-71), no local recurrence or metastatic disease and no tumor-related death were observed. CONCLUSIONS: When selected properly, the laparoscopic-endoscopic approach is considered to be curative and safe for resection of localized gastric tumors.
Assuntos
Endoscopia Gastrointestinal/métodos , Neoplasias Gastrointestinais/cirurgia , Laparoscopia/métodos , Humanos , Resultado do TratamentoRESUMO
BACKGROUND: The object of this study was to examine the effect of taurolidine on intraabdominal tumor growth in a laparoscopic animal model. We tested the cytotoxic, antiadhesive, and anti-invasive effects of this substance on CC531 adenocarcinoma cells in vitro and in vivo using WAG rats. METHODS: For in vitro experiments, Transwell dual chambers with polycarbonate filters coated with 100 microg/cm2 Matrigel were used to investigate the effects of 5, 10, and 20 microl of 2.0% taurolidine on the invasion of 1 x 10(5) CC531 adenocarcinoma cells. For the adhesion assays, tumor cells were applied onto microtiter plates coated with 5, 10, and 20 microl taurolidine and 0.9% NaCl solution for the control group subsequently. For in vivo experiments, 40 WAG rats were randomized into three therapy groups and one control group. All animals underwent laparoscopy and received 1 ml of CC531 adenocarcinoma cells (5 x 10(6) cells/ml) intraabdominally at the beginning of the procedure. According to the randomization, the rats were administered taurolidine with different concentrations or 1 ml of 0.9% NaCl solution for the control group. After 21 days, the animals were killed and the intraabdominal tumor weight was determined. RESULTS: For the in vitro experiments, we found a moderate cytotoxicity and a significant inhibition of tumor cell adhesion and invasion (p < 0.01) by all taurolidine concentrations used in the assay. For in vivo experiments, the application of all concentrations of taurolidine significantly decreased the intraperitoneal tumor weight (p < 0.001). CONCLUSION: Taurolidine significantly decreases adhesion and invasion of CC531 adenocarcinoma cells in vitro and significantly diminishes tumor growth in vivo. This may offer additional therapeutic options for laparoscopic surgery for colorectal cancer.
Assuntos
Adenocarcinoma/tratamento farmacológico , Antineoplásicos/farmacologia , Neoplasias do Colo/tratamento farmacológico , Taurina/análogos & derivados , Tiadiazinas/farmacologia , Animais , Antineoplásicos/administração & dosagem , Adesão Celular/efeitos dos fármacos , Linhagem Celular Tumoral , Modelos Animais de Doenças , Relação Dose-Resposta a Droga , Técnicas In Vitro , Laparoscopia , Masculino , Invasividade Neoplásica , Ratos , Ratos Endogâmicos , Taurina/administração & dosagem , Taurina/farmacologia , Tiadiazinas/administração & dosagemRESUMO
We report the case of a 33 year-old female with a history of 16 years of oral contraception who had been admitted to hospital for further diagnosis of multiple focal liver lesions; laboratory findings showed elevated levels of gamma-GT und AP. Diagnostic procedures showed no primary malignancy as possible reason for metastasis. All further imaging procedures compared with doppler-enhanced ultrasound did not help in diagnosis and lead to inconsistent results. Transcutaneous liver-biopsy showed normal liver histology. In laparoscopic biopsy the result was multifocal adenoma. Because of the rupture risk and potential malignant transformation and no change of sonomorphologic appearance within 12 months a liver-segment resection has been undertaken. Pathology revealed the diagnosis of a multifocal hyperplastic-adenomateous focal-nodular hyperplasia. This case shows that there is no need to use different methods of medical imaging redundantly. We favor a fine-needle double-puncture (lesion and extra-lesion) and tissue examination through an experienced pathologist. A total resection of the lesion is necessary in case of resting uncertainty to characterize its tissue characteristics.