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1.
Klin Monbl Augenheilkd ; 240(4): 569-573, 2023 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-37164396

RESUMO

Retinal periphlebitis (RPP) is a long-known entity in patients with multiple sclerosis (MS) and has not been revisited in the context of recent developments in MS pathogenesis and heterogeneity. We present six cases of RPP in three female and three male MS patients. They all have relapsing-remitting MS and did not have or had minor ocular symptoms. It is important to perform a thorough retinal examination in patients with MS, as peripheral and sectorial lesions could be unseen. A better knowledge on the concomitant involvement of retinal veins contributes to the understanding of immunopathology, with potentially distinct autoantigenic targets. RPP might serve as a subphenotype marker that may influence treatment choices in MS. Further research is needed.


Assuntos
Esclerose Múltipla , Flebite , Veia Retiniana , Humanos , Masculino , Feminino , Esclerose Múltipla/complicações , Esclerose Múltipla/diagnóstico , Retina , Flebite/etiologia , Flebite/complicações
2.
Int J Cardiol ; 125(1): 133-5, 2008 Mar 28.
Artigo em Inglês | MEDLINE | ID: mdl-17395289

RESUMO

Oxidative stress is a crucial pathophysiological mechanism of myocardial ischaemia-reperfusion injury (IRI). We evaluated the cardioprotective effects of a novel glutathione analogue, UPF1 (4-methoxy-L-tyrosinyl-gamma-L-glutamyl-L-cysteinyl-glycine; MW 483.5), on an isolated rat heart model of thirty-minute global ischaemia followed by 90 min of reperfusion. Treatment with UPF1 (1 mg/ml) prior to ischaemia improved the recovery of post-ischaemic left ventricular end-diastolic pressure (p=0.046), developed pressure (p=0.002) and coronary flow (p=0.01). No protective effect was observed when the hearts were treated with UPF1 after ischaemia. Administration of UPF1 had no influence upon infarct size or enzyme leakage from the heart. The results suggest that glutathione analogue type of biomolecules could possess a therapeutic potential in clinical situations where myocardial IRI is presented as myocardial stunning rather than tissue infarction.


Assuntos
Antioxidantes/farmacologia , Cardiotônicos/farmacologia , Glutationa/análogos & derivados , Isquemia Miocárdica/fisiopatologia , Traumatismo por Reperfusão Miocárdica/complicações , Miocárdio Atordoado/prevenção & controle , Animais , Glutationa/farmacologia , Coração/efeitos dos fármacos , Isquemia Miocárdica/tratamento farmacológico , Miocárdio Atordoado/etiologia , Estresse Oxidativo , Ratos , Espécies Reativas de Oxigênio , Fatores de Risco
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