Role of Growth Factors in Nasal Cartilage Development and Molding: A Comprehensive Review.

This review aims to investigate the properties of growth factors concerning the morphogenesis and development of nasal cartilage, which is fundamentally important for facial form and appearance. Since cartilage lacks a blood supply, it is more difficult to regenerate, as cartilage tissue obtains sustenance by diffusion. Cytokines are signalling molecules that control chondrocyte metabolism and extracellular matrix formation, which is required for cartilage development, homeostasis, and healing. Some craniofacial illnesses alter the composition of the cartilage and the structural organization of growth factors, allowing for moulding. TGF-ß (transforming growth factor-ß) encourages chondrocyte differentiation, whereas IGF-1 (insulin-like growth factor-1) stimulates cartilage-forming collagen synthesis and chondrocyte multiplication. We used the scoping review approach to present current research on the role of growth factors in the creation and architecture of nasal cartilage. We generally observed this structure before conducting specific experiments to determine the impact of growth agents on the development of chondrocytes and cartilage. Prominent findings increase our understanding of how growth factors influence the extracellular matrix, cell activities and features, and cartilage growth rate; all are critical for cartilage tissue development and repair. Research into growth factors and their physiological interactions with cartilage may help improve treatment's functional and aesthetic outcomes and our understanding of the origins and consequences of nasal congenital anomalies. This study emphasizes the importance of expanding knowledge and experience, as well as the use of growth factors in clinical practice, to stimulate cartilage development.

Friction and Forces in Orthodontics: Understanding Space Closure.

Orthodontic space closure is a critical aspect of treatment aimed at the correct positioning of teeth and is linked to tooth movement and optimal biomechanics. Therefore, the goal of this case study is to elucidate the process, describing the challenges encountered and the solutions adopted, with a focus on the frictionless technique and the use of devices like the Opus Loop to close spaces. Sliding mechanics, known for high friction, and segmental mechanics, characterized by low friction and continuous adjustment, are two significant technologies used. In this specific case, the frictionless methods applied to a 23-year-old female patient with protruding superior labial incisors included: extraction of the first premolars in all four quadrants, followed by consecutive wiring. Retraction was performed using an Opus Loop, significantly improving the patient's facial profile and dental arch over the next year and a half. As a result, the study demonstrates that the Opus Loop greatly reduces friction forces and offers an effective mechanism to influence tooth movement in orthodontic treatment regimens.