[Root morphological changes in maize and soybean intercropping system under different phosphorus levels]. / 不同磷水平下玉米-å¤§è±†é—´ä½œç³»ç»Ÿæ ¹ç³»å½¢æ€å˜åŒ–.

A pot experiment was conducted to investigate the changes of root morphology and its relationship with P uptake under different P levels (0, 50 and 100 mg P2O5·kg-1, represented by P0, P50 and P100, respectively). The results showed that intercropping significantly changed root morphological parameters of both maize and soybean, and increased the root:shoot ratio in soybean under different P levels. Intercropping significantly increased root length, root surface area, root volume, and root dry weight of maize and soybean by 25.6%, 22.0%, 39.2%, 34.3% and 28.1%, 29.7%, 37.3%, 62.3%, respectively, but significantly decreased the average root diameter by 15.2% and 11.7% compared to corresponding monoculture. The phosphorus uptake equivalent ratio (LERP) was >1, showing P uptake advantage of intercropping and that the LERP were unaffected by P levels. The root morphological changes induced by intercropping were closely related to P uptake improvement. The increases of maize root surface area and soybean root length were the main mechanisms driving efficient P uptake in maize and soybean intercropping. Based on the regression equation, 10% increase of maize root surface area or soybean root length caused 5%-10% increase of phosphorus uptake. P uptake of intercropped maize was not declined under P50 level compared to that of monoculture supplied with P100 level. In conclusion, maize and soybean intercropping has the potential to maintain crop P uptake when reducing application of phosphate fertilizer.

A Network Meta-Analysis of Short and Long-Term Efficacy of Targeted Therapy With Single or Double-Drug Regimens in the Treatment of Stage III/IV Malignant Melanoma Based on 16 Randomized Controlled Trials.

For the treatment of stage III/IV malignant melanoma (MM), a network meta-analysis (NMA) was conducted to compare the short and long-term efficacy of targeted therapy with single or double-drug regimens. All conducted randomized controlled trials (RCTs) searched from PubMed and Cochrane Library were included in the study for direct and indirect comparison for MM. The odds ratio (OR) and surface under the cumulative ranking curves (SUCRA) value of the targeted therapy with single or double-drug regimens for treatment of stage III/IV MM were also analyzed. To group the treatments according to their similarity with regards to both outcomes, cluster analyses were performed. Ultimately, 16 RCTs were incorporated for this NMA. The NMA revealed that the overall response rate (ORR) values of single-drug regimens (Vemurafenib [Vem], Dabrafenib [Dab], and Nivolumab [Niv]) were higher than those of Dacarbazine (Dac). Also the ORR values of double-drug regimens (Dab + Trametinib [Dab + Tra], Niv + Ipilimumab [Niv + Ipi], and Vem + Cobimetinib [Vem + Cob]) were moderately higher than those of Dac. The results of the SUCRA showed that short-term efficacy of single-drug regimens (Vem and Dab) were better, while the short-term efficacy of double-drug regimens (Dab + Tra and Vem + Cob) were relatively better. It was determined that Vem, Dab, and Niv might be the best choice in evaluating the treatment of stage III/IV MM among different single-drug targeted therapy regimens, while Dab + Tra, Niv + Ipi, and Vem + Cob might have better short-term efficacy among different double-drug targeted therapy regimens. J. Cell. Biochem. 119: 640-649, 2018. © 2017 Wiley Periodicals, Inc.

[Different mechanisms mediated the potentiation uterine smooth muscle caused by Polygala tenuifolia decoction progesterone in virginal rats].

OBJECTIVE: To research the effects of Polygala tenuifolia decoction on myoelectric activity of uterine smooth muscle and contractile activity of uterine smooth muscle strips of virginal rats. METHOD: To record the effects of P. tenuifolia decoction on myoelectric activity of uterine smooth muscle and contractile activity of uterine smooth muscle strips of virginal rats with biolap 410 biological system. Five blocking agents were used to study their mechanisms respectively. RESULT: Different dosages of water extract of P. tenuifolia (0.02, 0.04, 0.08 g x kg(-1)), could significantly potentiate uterine myoelectric activity and contractile activity of virginal rats. CONCLUSION: The effect of P. tenuifolia on myoelectric activity of uterine smooth muscle and contractile activity of uterine smooth muscle strips in rats may be mainly associated with H1 receptor, L-voltage-dependant calcium channels or prostaglandin synthese, its nothing to M receptor.