Insight into Cancer Immunity: MHCs, Immune Cells and Commensal Microbiota.

Cancer cells circumvent immune surveillance via diverse strategies. In accordance, a large number of complex studies of the immune system focusing on tumor cell recognition have revealed new insights and strategies developed, largely through major histocompatibility complexes (MHCs). As one of them, tumor-specific MHC-II expression (tsMHC-II) can facilitate immune surveillance to detect tumor antigens, and thereby has been used in immunotherapy, including superior cancer prognosis, clinical sensitivity to immune checkpoint inhibition (ICI) therapy and tumor-bearing rejection in mice. NK cells play a unique role in enhancing innate immune responses, accounting for part of the response including immunosurveillance and immunoregulation. NK cells are also capable of initiating the response of the adaptive immune system to cancer immunotherapy independent of cytotoxic T cells, clearly demonstrating a link between NK cell function and the efficacy of cancer immunotherapies. Eosinophils were shown to feature pleiotropic activities against a variety of solid tumor types, including direct interactions with tumor cells, and accessorily affect immunotherapeutic response through intricating cross-talk with lymphocytes. Additionally, microbial sequencing and reconstitution revealed that commensal microbiota might be involved in the modulation of cancer progression, including positive and negative regulatory bacteria. They may play functional roles in not only mucosal modulation, but also systemic immune responses. Here, we present a panorama of the cancer immune network mediated by MHCI/II molecules, immune cells and commensal microbiota and a discussion of prospective relevant intervening mechanisms involved in cancer immunotherapies.

Can national environmental protection supervision and control have a lasting impact on corporate production efficiency? - an empirical study based on the multi-phase difference-in-difference model.

National environmental protection supervision and control has become essential means to regulate the environmental behavior of enterprises. Furthermore, the optimization, promotion, and sustainability of relevant policies are key topics of inquiry. Taking the implementation of national environmental protection supervision policies as the time series, this paper studies the impact of national environmental protection supervision and control on corporate production efficiency. It uses the multi-phase difference-in-difference (DID) method and explores the sustainability of said policies. Results indicate that, first, national environmental protection supervision and control can considerably enhance corporate production efficiency, and green technology innovation plays a vital role as an intervening variable. Second, national environmental protection supervision and control can only boost the increase in corporate production efficiency in the short term, and the impact will no longer be noticeable in the third year. This paper provides a decision-making basis for constantly boosting and revising national environmental protection supervision and control policies and stimulating green technology innovation.

Coupling coordination degree for urban green growth between public demand and government supply in urban agglomeration: A case study from China.

The public demand for urban green growth (UGG) varies greatly due to climate conditions, resource endowments, geographical location; thus, understanding the coupling relationship between public demand and government supply is important to optimize government investment. This paper aims to evaluate the coupling coordination of UGG between public demand and government supply. An index system consisting of six aspects, including environment, society, economy, population, production and life, was used to evaluate the government supply. Meanwhile, citizens' demand was measured by the satisfaction for the six aspects. The coupling coordination degree model (CCDM) was established to analyze the government supply and public demand for UGG, and it was tested in the case of Shandong Peninsula urban agglomeration in China. The results indicated that citizens of Shandong Peninsula are basically satisfied, and the satisfaction for the environment, population and life is higher than the average value. From 2015 to 2019, the government supply level shows a trend of rising first and then declining, of which environment has been always at a high level for the five years. The coupling coordination degree of UGG shows the supply and demand in different cities of urban agglomerations is unbalanced, and the overall value of the eastern coast is higher than that of the western inland area. Moreover, the concept of relative satisfaction was put forwards, which is of great significance for regional policy. To improve UGG for a city, determining optimization objectives base on their evaluation results of coupling coordination degree and relative satisfaction is important, as well as the possible external reasons for the low coupling coordination degree.

Quantifying security and resilience of Chinese coastal urban ecosystems.

The emerging threat to the coastal urban ecosystems from increased intensity and frequency of weather events is a compelling reason for improving our understanding of the integrity of the existing ecosystem. Resilience of an ecosystem is a critical property that aids recovery and adaptation when subject to intense stress. Quantifying the resilience of an ecological system requires a detailed understanding of the vulnerabilities and interactions within a complex web of interconnected social, technological and economic networks. Through an ecological network analysis of ascendency and redundancy of the flux of energy and material flows, the causal relationships are established through structural equations modeling (SEM) techniques. A model based-on the five factors of driving force (D), pressure (P), state (S), impact (I), and response (R) (DPSIR), recognizes the different roles these factors play in the coastal urban ecological security system of China. Energy and material flows transmission equations of the ecological security network are developed to evaluate the resilience of the ecological security network. The results show that the ecological security network of Chinese coastal cities has a relatively high network occupation rate (A/C = 0.6898), indicating a relatively mature state of the ecological security network of coastal cities with sufficient metabolic capacity and steady status. The low vacancy rate (R/C = 0.3102) shows that the coastal ecological security network lacks flexibility of surplus space. The energy and material flows conversion and dissipation ability in the network are strong: the five factors of DPSIR are highly interdependent, and the ecological security network framework is both steady and mature. However, the resilience of the coastal urban ecosystem against external impacts is weak. It is critical for coastal cities to broaden their planning protocols to introduce more flexible space to increase resilience and guarantee a robust pathway for sustainable development. This study contributes to a rational method for testing the internal causal relationships among DPSIR linkages toward quantifying our understanding of the resilience of a security ecosystem.

Notable Enhancement of Phase Transition Performance and Luminous Transmittance in VO2 Films via Simple Method of Ar/O Plasma Post-Treatment.

Ar/O plasma irradiation is proposed for post-treatment of vanadium dioxide (VO2) films. Oxidation and surface migration were observed in the VO2 films following irradiation. This combined effect leads to an effective stoichiometry refinement and microstructure reconstruction in the interfacial area. A notable improvement in luminous transmittance and an enhancement in phase transition performance of the treated VO2 films were achieved. Compared with that of as-deposited VO2 films, the electrical phase transition amplitude of treated films increased more than two-fold. The relative improvement in luminous transmittance (380⁻780 nm) is 47.4% (from 25.1% to 37%) and the increase in solar transmittance is 66.9% (from 29.9% to 49.9%), which is comparable to or better than the previous work using anti-reflection (AR) coatings or doping methods. The interfacial boundary state proved to be crucial and Ar/O plasma irradiation offers an effective approach for further refinement of thermochromic VO2 films.