RESUMO
To shed light on the role of Streptococcus equisimilis (SE) in the pathogenesis of intervertebral disc infection, we report here a case of lumbar spondylodiscitis in a 37-year-old male caused by SE, with identification of this strain by cultures from L4-L5 lumbar disc biopsy. Intravenous therapy with penicillin and gentamycin combined with immobilization resulted in a rapid and complete recovery. The patient did not have underlying disease and showed no obvious history of exposure to animals. We conclude that SE may be responsible for both septic arthritis and spondylodiscitis.
Assuntos
Discite/etiologia , Vértebras Lombares/microbiologia , Infecções Estreptocócicas/complicações , Streptococcus/isolamento & purificação , Adulto , Biópsia , Discite/microbiologia , Discite/patologia , Discite/terapia , Gentamicinas/uso terapêutico , Humanos , Imobilização , Injeções Intravenosas , Disco Intervertebral/microbiologia , Disco Intervertebral/patologia , Vértebras Lombares/patologia , Masculino , Penicilinas/uso terapêutico , Infecções Estreptocócicas/patologia , Infecções Estreptocócicas/terapia , Streptococcus/classificação , Streptococcus/patogenicidadeRESUMO
The most serious complication of Paget's disease is sarcomatous degeneration of pagetic bone. Multifocal sarcomatous degeneration occurs mainly in polyostotic Paget's disease. Multifocal Paget's sarcoma is uncommon and can arise in any site. We report two cases of synchronous multifocal sarcomatous degeneration. The two patients were elderly women (aged 77 and 86 years, respectively) who developed sarcomatous lesions concomitantly, in the first case report in left ilium, left tibia, and first lumbar vertebra and in the second case report in the skull, right ilium, and sacrum. Whether these cases are due to the simultaneous development of several primaries or to metastases from a single primary remains unclear.
Assuntos
Neoplasias Ósseas/patologia , Osteíte Deformante/patologia , Osteossarcoma/patologia , Idoso , Idoso de 80 Anos ou mais , Neoplasias Ósseas/diagnóstico por imagem , Transformação Celular Neoplásica , Feminino , Humanos , Neoplasias Primárias Múltiplas , Osteíte Deformante/diagnóstico por imagem , Osteossarcoma/diagnóstico por imagem , Tomografia Computadorizada por Raios XRESUMO
Brown tumors are classic skeletal manifestations of hyperparathyroidism usually seen in severe forms with subperiosteal bone resorption. They are exceedingly rare at the spine. We report the case of a woman on hemodialysis who developed two brown tumors, including one at the spine, as the first manifestations of secondary hyperparathyroidism. There were no neurologic manifestations. The clinical and radiologic abnormalities resolved after parathyroidectomy preceded by a bisphosphonate infusion to prevent possible spinal lysis progression during the immediate postoperative period. In addition to the location of one of the brown tumors at the spine, unusual features in this case were the explosive onset of hyperparathyroidism and the absence of detectable subperiosteal resorption. We also suggest that bisphosphonate therapy given before parathyroidectomy may be useful in patients with spinal brown tumors.
Assuntos
Hiperparatireoidismo/complicações , Neoplasias da Coluna Vertebral/etiologia , Neoplasias da Coluna Vertebral/patologia , Vértebras Torácicas/patologia , Vértebras Torácicas/fisiopatologia , Feminino , Humanos , Pessoa de Meia-Idade , Glândulas Paratireoides/patologia , Glândulas Paratireoides/fisiopatologia , Glândulas Paratireoides/cirurgia , Radiografia , Neoplasias da Coluna Vertebral/diagnóstico por imagem , Vértebras Torácicas/diagnóstico por imagemRESUMO
Primary sarcomas of great vessels are rare and involve the aorta, pulmonary artery and inferior vena cava. The pathologic classification of these tumors can be made on the location of the sarcoma in relation to the vessel wall, luminal or mural. Luminal sarcomas are usually intimal sarcoma and mural sarcoma are most frequently leiomyosarcoma. The myofibroblastic or endothelial differentiation of these tumors is still debated. We report a case of intimal sarcoma of the pulmonary artery.
Assuntos
Artéria Pulmonar , Sarcoma/patologia , Neoplasias Vasculares/patologia , Adulto , Autopsia , Endotélio Vascular/patologia , Humanos , MasculinoRESUMO
The acetabulum is a rare location for osteoid osteoma. Conventional surgery of such lesions may require either a large bone resection, an arthrotomy, or a hip dislocation. This report describes the technique and results of percutaneous lesion removal using computed tomography guidance in three osteoid osteomas of the acetabulum. Histologic confirmation was obtained in the three cases. The three patients experienced complete pain relief with a mean followup of 36 months.
Assuntos
Acetábulo/cirurgia , Neoplasias Ósseas/cirurgia , Osteoma Osteoide/cirurgia , Acetábulo/patologia , Adulto , Biópsia , Neoplasias Ósseas/patologia , Criança , Seguimentos , Humanos , Masculino , Procedimentos Cirúrgicos Minimamente Invasivos , Osteoma Osteoide/patologia , Osteotomia/instrumentação , Osteotomia/métodos , Radiografia Intervencionista , Tomografia Computadorizada por Raios XAssuntos
Articulações dos Dedos/diagnóstico por imagem , Tuberculose Osteoarticular/diagnóstico por imagem , Adulto , Antituberculosos/uso terapêutico , Biópsia por Agulha , Diagnóstico Diferencial , Feminino , Seguimentos , Humanos , Radiografia , Tuberculose Osteoarticular/tratamento farmacológico , Tuberculose Osteoarticular/patologiaRESUMO
Myositis ossificans circumscripta (MOC) is a benign proliferation of fibrous tissue with large amounts of bone within soft tissues. Its clinical and radiological course is described and the value of CT and MR imaging is emphasized. Differential diagnosis includes soft tissue hematoma, infection or tumor. Florid reactive periostitis of the phalanges, turret exostosis, bizarre periosteal osteochondromatous proliferation in the hand and fibro-osseous pseudotumor of the digits are also described.
Assuntos
Miosite Ossificante/diagnóstico , Biópsia , Diagnóstico Diferencial , Humanos , Imageamento por Ressonância Magnética , Músculos/patologia , Miosite Ossificante/diagnóstico por imagem , Miosite Ossificante/patologia , Tomografia Computadorizada por Raios XRESUMO
This report describes the case of woman who was admitted to the hospital for highly destructive axial and peripheral arthropathy in association with acute malignant hypertension and skin purpura. Type I IgGkappa serum cryoglobulinemia was identified and was classified as a monoclonal gammopathy of unknown significance. Cryoglobulin was shown to crystallize in the serum and synovium fluid and was responsible for both granulomatous microcrystalline synovial inflammation and occlusive vasculopathy in the kidneys and skin. Cryocrystalglobulinemia pathogenicity and therapeutic implications are discussed.
Assuntos
Crioglobulinas/metabolismo , Artropatias/etiologia , Paraproteinemias/complicações , Doenças Vasculares/etiologia , Artrografia , Cristalização , Feminino , Humanos , Hipertensão Maligna/complicações , Artropatias/diagnóstico por imagem , Artropatias/patologia , Pessoa de Meia-Idade , Púrpura/complicaçõesRESUMO
Acrokerato-elastoidosis described by Costa is characterized by numerous little keratotic points and translucent horny wheals on the dorsal aspect of hands and (or) feets. The ultrastructural study shows lesions of the elastic tissue which is very rarefied with an abnormal structure, but also demonstrates alterations of the fibroblasts that contain dense granules at the periphery of their cytoplasm without elastic extracellular fibers, suggesting a trouble in the secretion or the excretion of the elastic material.
Assuntos
Acrodermatite/patologia , Adolescente , Tecido Elástico/patologia , Dermatoses do Pé/patologia , Dermatoses da Mão/patologia , HumanosRESUMO
Acrokerato-elastoidosis described by Costa is characterized by numerous little keratotic points and translucent horny wheals on the dorsal aspect of hands and (or) feet. The ultrastructural study shows lesions of the elastic tissue which is very rarefied with an abnormal structure, but also demonstrates alterations of the fibroblasts that contain dense granules at the periphery of their cytoplasm without elastic extracellular fibers, suggesting a trouble in the secretion or the excretion of the elastic material.