1.
Bioorg Med Chem Lett
; 19(4): 1218-23, 2009 Feb 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19131248
RESUMO
A series of N-benzyl-1-heteroaryl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamides targeting co-activator associated arginine methyltransferase 1 (CARM1) have been designed and synthesized. The potency of these inhibitors was influenced by the nature of the heteroaryl fragment with the thiophene analogues being superior to thiazole, pyridine, isoindoline and benzofuran based inhibitors.