Efficiency at optimal performance: A unified perspective based on coupled autonomous thermal machines.

We show that coupled autonomous thermal machines, in the presence of three heat reservoirs and following a global linear-irreversible description, can have efficiency at maximum power (EMP) which is analogous in form to the EMP of models with two (hot and cold) reservoirs. In particular, the temperature dependence of EMP in the coupled model is via only the ratio of hot and cold temperatures if the intermediate reservoir temperature is expressed as an algebraic mean of these temperatures. Many popular expressions of EMP in the literature can be recovered by making a choice of some standard mean. Further, the universal properties of EMP near equilibrium can be explained in terms of the properties of symmetric means. For the case of broken time-reversal symmetry, a universal second-order coefficient of 6/49 is predicted in the series expansion of EMP, analogous to the 1/8 coefficient in the time-reversal symmetric case.

Designing of mouse model: a new approach for studying sulphur mustard-induced skin lesions.

This study was planned to design a mouse model for studying sulphur mustard (SM)-induced skin injury. SM was applied dermally at dose of 5 or 10 mg kg(-1) in polyethyleneglycol-300 (PEG-300) or dimethylsulphoxide (DMSO) or acetone once. The changes in body weight, organ body weight indices (OBWI) and haematological and oxidative stress parameters were investigated over a period of 3-7 days and supported by histopathological observations. Exposure to SM in PEG-300 or DMSO resulted in a significant depletion in body weight, OBWI, hepatic glutathione (GSH) and elevation in hepatic lipid peroxidation, without affecting the blood GSH and hepatic oxidised glutathione (GSSG) levels. Interestingly, no aforesaid change was observed after dermal application of SM diluted in acetone. These biochemical changes were supported by the histological observations, which revealed pronounced toxic effect and damage to liver, kidney and spleen after dermal application of SM diluted in PEG-300 or DMSO. The skin showed similar microscopic changes after dermal application of SM in all the three diluents, however; the severity of lesions was found to be time and dose dependent. It can be concluded that dermal exposure of SM diluted in acetone can be used to mimic SM-induced skin toxicity without systemic toxicity in a mouse model.