Use of Psychedelics for Pain: A Scoping Review.

Chronic pain is a public health concern that affects approximately 1.5 billion people globally. Conventional therapeutic agents including opioid and non-opioid analgesics have been associated with adverse side effects, issues with addiction, and ineffective analgesia. Novel agents repurposed to treat pain via different mechanisms are needed to fill the therapeutic gap in chronic pain management. Psychedelics such as lysergic acid diethylamide and psilocybin (the active ingredient in psychedelic mushrooms) are thought to alter pain perception through direct serotonin receptor agonism, anti-inflammatory effects, and synaptic remodeling. This scoping review was conducted to identify human studies in which psychedelic agents were used for the treatment of pain. Twenty-one articles that assessed the effects of psychedelics in treating various pain states were included. The present scarcity of clinical trials and small sample sizes limit their application for clinical use. Overall, psychedelics appear to show promise for analgesia in patients with certain headache disorders and cancer pain diagnoses. Future studies must aim to examine the combined effects of psychotherapy and psychedelics on chronic pain.

Six ways to maximize survey response rates: lessons from a medical school accreditation survey in a Canadian setting.

Background: Surveys are being increasingly used to gather feedback and study data in healthcare professions. However, it may be challenging to achieve high response rates in surveys administered to healthcare professionals. The aim of this paper is to report six strategies that contributed to a high response rate on the Independent Student Analysis at the University of Toronto (U of T), which can be applied to other surveys to achieve strong response rates amongst healthcare professionals. Methods: In 2019, as part of accreditation for the U of T MD Program, we conducted the Independent Student Analysis, a student-led survey examining a medical student's experience. We review and critically evaluate the factors that contributed to a robust response rate amongst one of the largest cohorts of medical students in Canada. Results: Among 1080 students in the MD program, we achieved an unprecedented response rate of 87.2%. Six factors were identified that most contributed to our high response rate, including: faculty support, student representation, eliciting participant feedback, creating protected time for completion, offering incentives, and generating awareness. Conclusions: Eliciting high survey response rates from medical learners can be challenging. However, with careful consideration of learner feedback and effective employment of the strategies discussed in this paper, medical school faculty may better engage students in survey completion, achieving higher response rates and gathering richer insight, which can be used to more effectively enact meaningful change amongst healthcare professionals.

Contexte: Les enquêtes auprès de professionnels de la santé sont de plus en plus utilisées pour recueillir et étudier des perspectives et des données, mais il peut s'avérer difficile d'obtenir des taux de réponse élevés. Cet article vise à présenter six stratégies qui ont permis de susciter une forte participation à l'enquête de l'Analyse indépendante des étudiants à l'Université de Toronto et qui peuvent être transposées à d'autres contextes de sondage auprès des professionnels du domaine.En 2019, dans le cadre du processus d'agrément du programme de doctorat en médecine de l'Université de Toronto, nous avons réalisé l'Analyse indépendante des étudiants, une enquête dirigée par les étudiants en médecine visant à examiner leur expérience. Nous passons en revue et évaluons de manière critique les facteurs qui ont contribué à l'atteinte d'un taux de réponse élevé auprès d'une des plus grandes cohortes d'étudiants en médecine au Canada. Résultats: Nous avons obtenu un taux de réponse sans précédent de 87,2 % parmi les 1 080 étudiants inscrits au programme de médecine. Les six facteurs qui ont le plus contribué à ce taux de réponse élevé sont : le soutien du corps professoral, la représentation des étudiants, leur participation à la conception de l'enquête, la création de plages horaires réservées pour remplir le questionnaire, l'offre d'incitatifs et la sensibilisation. Conclusions: Il peut être difficile de susciter une forte participation aux questionnaires chez les étudiants en médecine. Cependant, en considérant attentivement les commentaires des apprenants et en utilisant efficacement les stratégies présentées dans cet article, le corps professoral seront en mesure de mobiliser les étudiants à participer davantage aux enquêtes et de tirer profit de leur apport pour éclairer la promotion de changements pertinents chez les professionnels de la santé.

Comparing Analgesia on an As-Needed Basis to Traditional Intravenous Patient-Controlled Analgesia Within Fast-Track Orthopedic Procedures: A Randomized Controlled Trial.

BACKGROUND: The aim was to determine if the use of intravenous patient-controlled analgesia (IVPCA) in a fast-track joint replacement program is associated with increased use of perioperative opioid consumption and increased length of hospital stay. DESIGN: A prospective, double-blind, randomized controlled trial. SETTINGS: Academic hospital. PARTICIPANTS/SUBJECTS: A total of 80 patients aged 18-85 years, with body mass index (BMI) 18-40, undergoing elective total knee arthroplasty were recruited. METHODS: Pre-operatively, patients received gabapentin, celecoxib, and acetaminophen. Peri-operatively, patients received spinal anesthesia with morphine and fentanyl, and periarticular local anesthetic administration by the surgeon. Postoperatively, 80 patients were randomized by a computer-generated sequence into IVPCA group (group A, n = 40) and non-IVPCA group (group B, n = 40). RESULTS: The primary outcome was 48-hour postoperative opioid consumption and length of hospital stay. Secondary outcomes included side effects of opioids, patient satisfaction, and pain scores. There was no significant difference within 48-hour postoperative opioid consumption (median 61.3 vs. 87.5, p = .181) and length of hospital stay (median 49.8 hours vs. 49.5 hours; p = .89) between the two groups. Also, there was no significant difference in patient satisfaction (median 5 in both groups), pain scores, and opioid-related side effects. CONCLUSIONS: IVPCA was associated with nonsignificant reduction in opioid exposure in elective total knee arthroplasty surgery within 48 hours. Neither group was superior in terms of length of hospital stay, opioid related side-effects, pain scores, and patient satisfaction.

Fostering trust, collaboration, and a culture of continuous quality improvement: A call for transparency in medical school accreditation.

Medical schools provide the foundation for a physician's growth and lifelong learning. They also require a large share of government resources. As such, they should seek opportunities to maintain trust from the public, their students, faculty, universities, regulatory colleges, and each other. The accreditation of medical schools attempts to assure stakeholders that the educational process conforms to appropriate standards and thus can be trusted. However, accreditation processes are poorly understood and the basis for accrediting authorities' decisions are often opaque. We propose that increasing transparency in accreditation could enhance trust in the institutions that produce society's physicians. While public reporting of accreditation results has been established in other jurisdictions, such as Australia and the United Kingdom, North American accrediting bodies have not yet embraced this more transparent approach. Public reporting can enhance public trust and engagement, hold medical schools accountable for continuous quality improvement, and can catalyze a culture of collaboration within the broader medical education ecosystem. Inviting patients and the public to peer into one of the most formative and fundamental parts of their physicians' professional training is a powerful tool for stakeholder and public engagement that the North American medical education community at large has yet to use.

Les facultés de médecine procurent les bases pour la croissance professionnelle et le développement professionnel continu. Elles absorbent également une grande part des ressources gouvernementales. Conséquemment, elles devraient chercher des occasions de maintenir la confiance du public, de leurs étudiants, du corps professoral, des universités, des organismes de réglementation et les unes des autres. L'accréditation des facultés de médecine vise à assurer les parties prenantes que le processus éducationnel est conforme aux normes appropriées et donc de confiance. Toutefois, les processus d'accréditation sont mal compris et les fondements des décisions d'accréditation des autorités sont souvent opaques.Nous proposons que l'accroissement de la transparence du processus d'agrément puisse rehausser la confiance dans les institutions qui forment les médecins de notre société. Bien que la diffusion publique des résultats de l'agrémentsoit établie dans d'autres juridictions, comme en Australie et au Royaume-Uni, les organismes d'agrément de l'Amérique du Nord n'ont pas encore adopté cette approche plus transparente. Les la diffusion publique peut améliorer la confiance et la participation du public, tenir les facultés responsables de l'amélioration continue de la qualité et catalyser une culture de collaboration au sein de l'écosystème élargi de la formation médicale. Inviter les patients et le public à scruter l'une des étapes les plus formative fondamentale de la formation professionnelle de leurs médecins est un puissant outil pour les parties prenantes ainsi que pour susciter la participation du public. Il reste à l'utiliser dans la communauté d'éducation médicale nord-américaine.

The role of ultrasound in front-of-neck access for cricothyroid membrane identification: A systematic review.

PURPOSE: Conventional palpation techniques for cricothyroid membrane (CTM) identification are inaccurate and unreliable. Ultrasound plays a multi-faceted role in airway management, however there is limited literature around its use for CTM identification prior to cricothyrotomies. This review sought to compare ultrasound to palpation in the general population, identify its indications in subjects with ill-defined neck anatomy, and determine its role in defining neck anatomy. METHODS: Two reviewers independently assessed titles, abstracts and full-text English articles through the Ovid Medline and EMBASE databases. Studies related to ultrasound for CTM assessment and/or cricothyrotomy in subjects older than 12 years were included. RESULTS: Fourteen studies were selected. Compared to palpation, ultrasound has greater accuracy, but longer CTM identification times in those with normal airway anatomy. Interestingly, ultrasound offers comparable times to palpation in patients with difficult airways. Ultrasound also helps define anatomical parameters in the neutral and extended neck positions thereby underscoring the importance of neck positioning during cricothyrotomies and confirming consensus-based incision recommendations set by the Difficult Airway Society. CONCLUSION: Ultrasound appears to be superior to palpation for CTM localization especially in those with difficult airway anatomy and objectively defines neck anatomy. Its pre-emptive use should be incorporated during difficult airway management.

Kidney cancer survivorship care: Patient experiences in a Canadian setting.

INTRODUCTION: The incidence of kidney cancer (KCa) in Canada is rising. Despite this, there is a shortage of research assessing KCa care experiences. This study aims to explore the current experiences of KCa survivors related to treatment and management, information provision, and barriers to care. METHODS: A cross-sectional, descriptive study of KCa patients was conducted online and through various cancer centers across Canada. English- and French-speaking adults who received a KCa diagnosis and were currently undergoing treatment or had completed treatment in Canada were eligible to participate. RESULTS: In total, 368 surveys were completed. Ten percent of respondents had not yet received treatment, 29% were receiving treatment, and 56% had completed treatment. Most respondents (72%) had localized KCa (stage 0-3) at diagnosis. Sixty-one percent of respondents reported that their doctors discussed various treatment options with them and 24% reported discussing applicable clinical trials. Most (85%) respondents received information about their KCa and 36% discussed where to get information about their disease and support. The most commonly reported barriers to care were side effects (26%), system delays (26%), not having access to certain treatments (25%), and financial burden (24%). More participants in Central Region and Quebec (p=0.004) and rural/suburban (p=0.014) areas reported lacking access to certain treatments and KCa experts. CONCLUSIONS: This was the first large-scale study to explore access to care experiences of Canadian KCa survivors. Results show examples of good patient-centered care and provide new practical information that can inform efforts to improve patient-centered care for KCa patients.

Comparison of meperidine, tramadol and fentanyl for post-spinal shivering prevention during cesarean delivery: A double-blind randomized controlled trial.

AIM: To assess the effects of intravenously administered meperidine, fentanyl and tramadol in reducing the incidence, onset time and severity of the shivering response in parturients during cesarean delivery under spinal anesthesia. Secondary outcomes included patient satisfaction and sedation scores. METHODS: After Ethics board approval and informed written consent, 350 parturients (ASA physical status I or II), between 20 and 40 years of age, undergoing emergency or elective cesarean delivery under spinal anesthesia were recruited. Parturients were then randomly allocated to seven study groups: normal saline (control), low-dose meperidine (0.5 mg/kg), high-dose meperidine (0.75 mg/kg), low-dose fentanyl (0.5 mcg/kg), high-dose fentanyl (0.75 mcg/kg), low-dose tramadol (0.5 mg/kg) and high-dose tramadol (0.75 mg/kg). The incidence, onset time and severity of shivering, along with patient satisfaction and sedation scores were measured. RESULTS: All study drugs showed significant reduction in incidence, onset time and severity of shivering and greater satisfaction scores compared to the control group (P < 0.01). Within each drug class, no significant differences in shivering were found between the high-dose and low-dose groups. Among study drugs, low-dose tramadol was superior due to shivering prevention and significantly reduced sedation. CONCLUSION: Intravenously administered meperidine, fentanyl and tramadol reduce shivering incidence, onset time and severity in parturients undergoing cesarean delivery following spinal anesthesia. Importantly, low-dose intravenous tramadol (0.5 mg/kg) allowed shivering prevention and low sedation scores, thereby offering greater parturient satisfaction and better maternal-newborn bonding.

Category specificity in the medial temporal lobe: A systematic review.

Theoretical accounts of medial temporal lobe (MTL) function ascribe different functions to subregions of the MTL including perirhinal, entorhinal, parahippocampal cortices, and the hippocampus. Some have suggested that the functional roles of these subregions vary in terms of their category specificity, showing preferential coding for certain stimulus types, but the evidence for this functional organization is mixed. In this systematic review, we evaluate existing evidence for regional specialization in the MTL for three categories of visual stimuli: faces, objects, and scenes. We review and synthesize across univariate and multivariate neuroimaging studies, as well as neuropsychological studies of cases with lesions to the MTL. Neuroimaging evidence suggests that faces activate the perirhinal cortex, entorhinal cortex, and the anterior hippocampus, while scenes engage the parahippocampal cortex and both the anterior and posterior hippocampus, depending on the contrast condition. There is some evidence for object-related activity in anterior MTL regions when compared to scenes, and in posterior MTL regions when compared to faces, suggesting that aspects of object representations may share similarities with face and scene representations. While neuroimaging evidence suggests some hippocampal specialization for faces and scenes, neuropsychological evidence shows that hippocampal damage leads to impairments in scene memory and perception, but does not entail equivalent impairments for faces in cases where the perirhinal cortex remains intact. Regional specialization based on stimulus categories has implications for understanding the mechanisms of MTL subregions, and highlights the need for the development of theoretical models of MTL function that can accommodate the differential patterns of specificity observed in the MTL.