Dermatological Manifestations of Parkinson's Disease: Clues for Diagnosis.

Background and objective Parkinson's disease (PD) is a common neurodegenerative disorder. There are various manifestations of PD. Among them, motor dysfunction has been studied in many research studies; however, few studies are available related to the dermatological manifestations of PD. This study was conducted with the aim to shed light on various skin conditions that occur in PD. Methods This cross-sectional study was conducted at a tertiary care hospital in Pakistan for a period of nine months; 107 patients with PD were included after obtaining informed consent. A self-administrated questionnaire was used to record demographic data and dermatological findings. Results Among the various dermatological manifestations, patients with PD most commonly presented with seborrheic dermatitis (46.7%) and rosacea (10.2%). Other manifestations included bullous pemphigoid (7.4%) and melanoma (4.6%). Conclusion The study revealed several dermatological manifestations of PD, which usually get overlooked by neurologists. Through this study, we want to emphasize that PD, apart from all the motor signs and symptoms, can also present as skin problems, and hence, a multi-disciplinary approach should be taken while managing PD.

Sensitivity, Specificity and Accuracy of Androgen Deficiency in Ageing Male (ADAM) Questionnaire for the Clinical Detection of Androgen Deficiency in the Male Population in Pakistan.

INTRODUCTION: Androgen deficiency in relation to the increasing age is quite prevalent worldwide. However, diagnosing it in low-income countries is quite a challenge due to cost concerns. Through this study, we plan to measure the sensitivity and specificity of the Androgen Deficiency in Ageing Male (ADAM) questionnaire in the Pakistani population. METHODS: A cross-sectional survey study was conducted from September 2019 to November 2019 in a Pakistani tertiary care hospital. Two hundred and fifty-five participants belonging to ages 30-69 years completed the ADAM Questionnaire in the out-patient department. Venous blood samples were taken to check serum total testosterone levels. RESULTS: The ADAM questionnaire revealed 90.12% sensitivity, 41.3% specificity, 45.34% positive predictive value, 90.80% negative predictive value, and 61.29% accuracy in the Pakistani population. CONCLUSION: Low specificity and positive predictive value have been shown by the ADAM questionnaire. Hence, it cannot be used as a diagnostic tool to detect androgen deficiency, replacing the blood sample.

Clinical Spectrum of Hyponatremia in Patients with Stroke.

Introduction Hyponatremia is a common electrolyte imbalance, which is readily observed in patients with ischemic as well as hemorrhagic stroke. It is mostly hypoosmolal and may be due to syndrome of inappropriate anti-diuretic hormone (SIADH) or cerebral salt wasting syndrome (CSWS). The aim of this study was to evaluate the clinical spectrum of hyponatremia in patients of both hemorrhagic and ischemic strokes. Methods In this prospective observational study, all patients admitted with stroke were screened for serum sodium levels right after hospital admission. Patients with serum sodium levels <135 mEq/L were included. Their demographic characteristics, type of stroke, etiology of hyponatremia, and site of hemorrhage/vascular territory ischemia was included. Results Hyponatremia was diagnosed in 34.2% of patients. Their mean serum sodium level was 130.4 ± 3.5 (mEq/L). Ischemic stroke was more common in the hyponatremia group (67.7%), and SIADH was a more common cause of hyponatremia (71.1%). In hyponatremic patients with hemorrhagic stroke, right putamen hemorrhage was seen in 50% of patients with SIADH, and right thalamus was seen in 73.3% patients with CSWS. In hyponatremic patients with ischemic stroke, left middle cerebral artery ischemia was seen in 47% patients with SIADH and right middle cerebral artery ischemia was seen in 55% patients with CSWS. Conclusion In patients with hyponatremia secondary to stroke, ischemic stroke is a common entity. SIADH remains a more frequently witnessed underlying pathology in hyponatremic stroke patients.

Serum Sodium Profile of Congestive Heart Failure Patients and its Impact on Their Outcome at Discharge.

Introduction Patients with congestive heart failure (CHF) readily present with electrolyte imbalance which commonly includes deficiencies of sodium, potassium, and magnesium. Hyponatremia occurs in advanced stages of CHF and is associated with adverse disease outcome-longer hospital stay, severity of CHF, and increased risk of mortality. Methods In this observational, single-center, prospective, case-control study adult patients admitted with clinical diagnosis of CHF were included after informed consent. Their demographic, clinical, and biochemical profile was attained. Patients with low serum sodium (hyponatremia) were grouped as "cases" and patients with normal serum sodium profile (normonatremia) were grouped as "controls". Factors associated with both groups and their hospital outcome were compared. SPSS for Windows version 16 (SPSS Inc., Chicago, IL, USA) was utilized. Results Hyponatremia (serum sodium <135 mmol/L) was present in 58/189 (30.7%) patients admitted with CHF. Younger patients with non-ischemic CHF, and history of previous diagnosis, treatment, and hospitalization due to CHF were more likely to be affected. Diabetic nephropathy, chronic kidney disease, salt-restricted diet, drugs including furosemide, spironolactone, and angiotensin-converting enzyme inhibitors, low serum potassium, and reduced GFR were also related to hyponatremia. Hyponatremic CHF patients showed adverse hospital outcome on all parameters including higher death rate (12% vs. 0.8%), longer duration of hospital day, and deranged blood pressures and severe CHF at the time of discharge. Conclusion Hyponatremic CHF patients are associated with prolonged hospital stay, more severe form of CHF, and deranged blood pressures. Overall, hyponatremia is an indirect clinical indicator of circulatory dysfunction and should guide a clinician for closer observation as outcomes could be poor. These patients also have higher in-hospital mortality risk.