Current advancements and prospects of enzymatic and non-enzymatic electrochemical glucose sensors.

This review discusses the most current developments and future perspectives in enzymatic and non-enzymatic glucose sensors, which have notably evolved over the preceding quadrennial period. Furthermore, a thorough exploration encompassed the sensor's intricate fabrication processes, the diverse range of materials employed, the underlying principles of detection, and an in-depth assessment of the sensors' efficacy in detecting glucose levels within essential bodily fluids such as human blood serums, urine, saliva, and interstitial fluids. It is worth noting that the accurate quantification of glucose concentrations within human blood has been effectively achieved by utilizing classical enzymatic sensors harmoniously integrated with optical and electrochemical transduction mechanisms. Monitoring glucose levels in various mediums has attracted exceptional attention from industrial to academic researchers for diabetes management, food quality control, clinical medicine, and bioprocess inspection. There has been an enormous demand for the creation of novel glucose sensors over the past ten years. Research has primarily concentrated on succeeding biocompatible and enhanced sensing abilities related to the present technologies, offering innovative avenues for more effective glucose sensors. Recent developments in wearable optical and electrochemical sensors with low cost, high stability, point-of-care testing, and online tracking of glucose concentration levels in biological fluids can aid in managing and controlling diabetes globally. New nanomaterials and biomolecules that can be used in electrochemical sensor systems to identify glucose concentration levels are developed thanks to advances in nanoscience and nanotechnology. Both enzymatic and non-enzymatic glucose electrochemical sensors have garnered much interest recently and have made significant strides in detecting glucose levels. In this review, we summarise several categories of non-enzymatic glucose sensor materials, including composites, non-precious transition metals and their metal oxides, hydroxides, precious metals and their alloys, carbon-based materials, conducting polymers, metal-organic framework (MOF)-based electrocatalysts, and wearable device-based glucose sensors deeply.

Cobalt ferrite/semiconducting single-walled carbon nanotubes based field-effect transistor for determination of carbamate pesticides.

Carbaryl and carbofuran are the carbamate pesticides which have been widely used worldwide to control insects in crops and house. If the pesticides entered in to the food products and drinking water, they could cause serious health effects in humans. Therefore, the development of a rapid, simple, sensitive and selective analytical device for on-site detection of carbamates is crucial to evaluate food and environmental samples. Recently, semiconducting single-walled carbon nanotube-based field effect transistors (s-SWCNT/FETs) have shown several advantages such as high carrier mobility, good on/off ratio, quasi ballistic electron transport, label-free detection and real-time response. Herein, cobalt ferrite (CFO) nanoparticles decorated s-SWCNTs have been prepared and used to bridge the source and drain electrodes. As-prepared CFO/s-SWCNT/FET had been used for the non-enzymatic detection of carbaryl and carbofuran. When used as a sensing platform, the CFO/s-SWCNT hybrid film exhibited high sensitivity, and selectivity with a wide linear range of detection from 10 to 100 fMand the lowest limit of detections for carbaryl (0.11 fM) and carbofuran (0.07 fM) were estimated. This sensor was also used to detect carbaryl in tomato and cabbage samples, which confirmed its practical acceptance. Such performance may be attributed to the oxidation of carbamates by potent catalytic activity of CFO, which led to the changes in the charge transfer reaction on the s-SWCNTs/FET conduction channel. This work presents a novel CFO/s-SWCNT based sensing system which could be used to quantify pesticide residues in food samples.

Amperometric determination of salivary thiocyanate using electrochemically fabricated poly (3, 4-ethylenedioxythiophene)/MXene hybrid film.

Thiocyanate (SCN) is a hazardous byproduct of the detoxification of cyanide. Even in minute quantity, the SCN has a negative impact on health. Although there are several ways for SCN analysis, an efficient electrochemical procedure has hardly ever been attempted. Here, the author reports the development of a highly selective and sensitive electrochemical sensor for SCN utilizing Poly (3, 4-Ethylenedioxythiophene) incorporated MXene (PEDOT/MXene) modified screen-printed electrode (SPE). The Raman, X-ray photoelectron (XPS), and X-ray diffraction (XRD) analyses support the effective integration of PEDOT on the MXene surface. Further, scanning electron microscopy (SEM) is employed to demonstrate the formation of MXene and PEDOT/MXene hybrid film. In order to specifically detect SCN in phosphate buffer media (pH 7.4), the PEDOT/MXene hybrid film is grown on the SPE surface via the electrochemical deposition method. Under the optimized condition, the PEDOT/MXene/SPE-based sensor provides a linear response against SCN from 10 to 100 µM and 0.1 µM to 1000 µM with the lowest limit of detections (LOD) of 1.44 µM and 0.0325 µM by differential pulse voltammetry (DPV) and amperometry, respectively. For accurate detection of SCN, our newly created PEDOT/MXene hybrid film-coated SPE demonstrates excellent sensitivity, selectivity, and repeatability. Ultimately, this novel sensor can be used to detect SCN precisely in environmental and biological samples.

2D MXene/graphene nanocomposite preparation and its electrochemical performance towards the identification of nicotine level in human saliva.

The quantitative analysis of neurological drugs is critical since the kinetics of body fluids is strongly dependent on the dosage of the drug levels. Thus, the study of neurological medicines is significant because of the major diseases connected to it, for instance, Alzheimer's and Parkinson's diseases. Herein, a 2D hybrid MXene/graphene (MX/Gr) film was synthesized through a top-down approach and utilized to prepare an electrochemical transducer for the electrochemical sensing of nicotine. The X-ray diffraction (XRD), Raman and X-ray photoelectron spectroscopy (XPS) confirmed the successful incorporation of MX with Gr sheets. The high-resolution scanning electron microscopy (HR-SEM) and transmission electron microscopy (TEM) have been used to confirm the formation of MX, graphene sheets and the MX/Gr hybrid film. Furthermore, the MX/Gr hybrid film composite modified glassy carbon electrode (GCE) was prepared to selectively detect the nicotine in phosphate buffer medium (0.1 M PBS, pH~7.4). Under the optimized condition, the MX/Gr/GCE based sensor provided a linear response against nicotine from 1 to 55 µM and 30 nM - 600 nM with the lowest limit of detections (LOD) of 290 nM and 0.28 nM by differential pulse voltammetry (DPV) and amperometry, respectively. This newly developed MX/Gr hybrid film modified electrode displayed a remarkable selectivity, sensitivity, and reproducibility for accurate detection of nicotine. Finally, this new sensor was applied to detect nicotine in human/artificial saliva samples with high accuracy.

Preparation of 2D Graphene/MXene nanocomposite for the electrochemical determination of hazardous bisphenol A in plastic products.

Bisphenol A (BPA) is one of the major contaminants with significant health hazards, which could also affect the endocrine system or induce cancer. It is essential to develop a highly sensitive and selective BPA sensor for environmental and food safety. Herein, 2D hybrid graphene/Ti3C2Tx nanocomposite (Gr/MXene) was prepared via a top-down method and then used to fabricate an electrochemical BPA sensor. The X-ray diffraction spectrometer (XRD) and Raman spectroscopy analysis were carried out to verify the successful formation of Gr sheets with MXene. The high resolution scanning electron microscopy (HR-SEM) was revealed the formation of MXene, and Gr/MXene nanocomposite. Furthermore, the 2D hybrid Gr/MXene nanocomposite modified glassy carbon electrode (GCE) was prepared for BPA oxidation in 100 mM phosphate buffer solution (PBS). Under the optimized condition, the Gr/MXene/GCE was displayed a linear range of detection from 10 to 180 nM and 1 to 10 µM BPA with the detection limits of 4.08 nM and 0.35 µM by amperometry and differential pulse voltammetry (DPV), respectively. Moreover, the proposed Gr/MXene modified electrode exhibited excellent stability, selectivity, repeatability and reproducibility towards the BPA detection. As a proof of concept, Gr/MXene modified sensor was effectively used to detect BPA in modern plastic products with the recovery ranging from 99.2 to 104.5%.

Selective Chemistry-Based Separation of Semiconducting Single-Walled Carbon Nanotubes and Alignment of the Nanotube Array Network under Electric Field for Field-Effect Transistor Applications.

Semiconducting single-walled carbon nanotubes (s-SWCNTs) are considered as a replacement for silicon in field-effect transistors (FETs), solar cells, logic circuits, and so forth, because of their outstanding electronic, optical, and mechanical properties. Herein, we have studied the reaction of pristine SWCNTs dispersed in a pluronic F-68 (PF-68) polymer solution with para-amino diphenylamine diazonium sulfate (PADDS) to separate nanotubes based on their metallicity. The preferential selectivity of the reactions was monitored by changes in the semiconducting (S22 and S33) and metallic (M11) bands by ultraviolet-visible-near infrared spectroscopy. Metallic selectivity depended on the concentrations of PADDS, reaction time, and the solution pH. Furthermore, separation of pure s-SWCNTs was confirmed by Raman spectroscopy and Fourier-transform infrared spectroscopy. After the removal of metallic SWCNTs, direct current electric field was applied to the pure s-SWCNT solution, which effectively directed the nanotubes to align in one direction as nanotube arrays with a longer length and high density. After that, electrically aligned s-SWCNT solution was cast on a silicon substrate, and the length of the nanotube arrays was measured as ∼2 to ∼14 µm with an areal density of ∼2 to ∼20 tubes/µm of s-SWCNTs. Next, electrically aligned s-SWCNT arrays were deposited on the channel of the FET device by drop-casting. Field-emission scanning electron microscopy and electrical measurements have been carried out to test the performance of the aligned s-SWCNTs/FETs. The fabricated FETs with a channel length of 10 µm showed stable electrical properties with a field-effect mobility of 30.4 cm2/Vs and a log10 (I on/I off) current ratio of 3.96. We envisage that this new chemical-based separation method and electric field-assisted alignment could be useful to obtain a high-purity and aligned s-SWCNT array network for the fabrication of high-performance FETs to use in digital and analog electronics.

Preparation of hybrid paper electrode based on hexagonal boron nitride integrated graphene nanocomposite for free-standing flexible supercapacitors.

Flexible energy storage devices have received great interest due to the increasing demand for wearable and flexible electronic devices with high-power energy sources. Herein, a novel hybrid flexible hexagonal boron nitride integrated graphene paper (BN/GrP) is fabricated from 2D hexagonal boron nitride (h-BN) nanosheets integrated with graphene sheets dispersion via a simple vacuum filtration method. FE-SEM indicated that layered graphene nanosheets tightly confined with h-BN nanosheets. Further, the Raman spectroscopy confirmed successful integration of BN with graphene. As-prepared BN/GrP free-standing flexible conductive paper showed high electrical conductivity of 5.36 × 104 S m-1 with the sheet resistance of 8.87 Ω sq-1. However, after 1000 continuous bending cycles, the BN/GrP sheet resistance increased just about 8.7% which indicated good flexibility of the paper. Furthermore, as-prepared BN/GrP showed excellent specific capacitance of 321.95 F g-1 at current density of 0.5 A g-1. In addition, the power and energy densities were obtained as 3588.3 W kg-1, and 44.7 W h kg-1, respectively. The stability of the prepared flexible electrode was tested in galvanostatic charge/discharge cycles, where the results showed the 96.3% retention even after 6000 cycles. These results exhibited that the proposed BN/GrP may be useful to prepare flexible energy-storage systems.