A novel collaborative self-supervised learning method for radiomic data.

The computer-aided disease diagnosis from radiomic data is important in many medical applications. However, developing such a technique relies on labeling radiological images, which is a time-consuming, labor-intensive, and expensive process. In this work, we present the first novel collaborative self-supervised learning method to solve the challenge of insufficient labeled radiomic data, whose characteristics are different from text and image data. To achieve this, we present two collaborative pretext tasks that explore the latent pathological or biological relationships between regions of interest and the similarity and dissimilarity of information between subjects. Our method collaboratively learns the robust latent feature representations from radiomic data in a self-supervised manner to reduce human annotation efforts, which benefits the disease diagnosis. We compared our proposed method with other state-of-the-art self-supervised learning methods on a simulation study and two independent datasets. Extensive experimental results demonstrated that our method outperforms other self-supervised learning methods on both classification and regression tasks. With further refinement, our method will have the potential advantage in automatic disease diagnosis with large-scale unlabeled data available.

Non-Fragile Observer-Based Adaptive Integral Sliding Mode Control for a Class of T-S Fuzzy Descriptor Systems With Unmeasurable Premise Variables.

The issue of non-fragile observer-based adaptive integral sliding mode control for a class of Takagi-Sugeno (T-S) fuzzy descriptor systems with uncertainties and unmeasurable premise variables is investigated. General nonlinear systems are represented by nonlinear T-S fuzzy descriptor models, because premise variables depend on unmeasurable system states and fuzzy models have different derivative matrices. By introducing the system state derivative as an auxiliary state vector, original fuzzy descriptor systems are transformed into augmented systems for which system properties remain the same. First, a novel integral sliding surface, which includes estimated states of the sliding mode observer and controller gain matrices, is designed to obtain estimation error dynamics and sliding mode dynamics. Then, some sufficient linear matrix inequality (LMI) conditions for designing the observer and the controller gains are derived using the appropriate fuzzy Lyapunov functions and Lyapunov theory. This approach yields asymptotically stable sliding mode dynamics. Corresponding auxiliary variables are introduced, and the Finsler's lemma is employed to eliminate coupling of controller gain matrices, observer gain matrices, Lyapunov function matrices, and/or observer gain perturbations. An observer-based integral sliding mode control strategy is obtained to assure that reachability conditions are satisfied. Moreover, a non-fragile observer and a non-fragile adaptive controller are developed to compensate for system uncertainties and perturbations in both the observer and the controller. Finally, example results are presented to illustrate the effectiveness and merits of the proposed method.