Cooperative Fe/Co-Catalyzed Remote Desaturation for the Synthesis of Unsaturated Amide Derivatives.

Unsaturated amides represent common functional groups found in natural products and bioactive molecules and serve as versatile synthetic building blocks. Here, we report an iron(II)/cobalt(II) dual catalytic system for the syntheses of distally unsaturated amide derivatives. The transformation proceeds through an iron nitrenoid-mediated 1,5-hydrogen atom transfer (1,5-HAT) mechanism. Subsequently, the radical intermediate undergoes hydrogen atom abstraction from vicinal methylene by a cobaloxime catalyst, efficiently yielding ß,γ- or γ,δ-unsaturated amide derivatives under mild conditions. The efficiency of Co-mediated HAT can be tuned by varying different auxiliaries, highlighting the generality of this protocol. Remarkably, this desaturation protocol is also amenable to practical scalability, enabling the synthesis of unsaturated carbamates and ureas, which can be readily converted into various valuable molecules.

Diagnostic Reference Levels in Interventional Pediatric Cardiology: Two-Year Experience in a Tertiary Referral Hospital in Latin America.

The goal of the present study was to propose the first local diagnostic reference levels (DRLs) for interventional pediatric cardiology procedures in a large hospital in Colombia. The data collection period was from April 2020 to July 2022. The local DRLs were calculated as the 3rd quartile of patient-dose distributions for the kerma-area product (Pka) values. The sample of collected clinical procedures (255) was divided into diagnostic and therapeutic procedures and grouped into five weight and five age bands. The Pka differences found between diagnostic and therapeutic procedures were statistically significant in all weight and age bands, except for the 1-5-year age group. The local DRLs for weight bands were 3.82 Gy·cm2 (<5 kg), 7.39 Gy·cm2 (5-<15 kg), 19.72 Gy·cm2 (15-<30 kg), 28.99 Gy·cm2 (30-<50 kg), and 81.71 Gy·cm2 (50-<80 kg), respectively. For age bands, the DRLs were 3.97 Gy·cm2 (<1 y), 9.94 Gy·cm2 (1-<5 y), 20.82 Gy·cm2 (5-<10 y), 58.00 Gy·cm2 (10-<16 y), and 31.56 Gy·cm2 (<16 y), respectively. In conclusion, when comparing our results with other existing DRL values, we found that they are similar to other centers and thus there is scope to continue optimizing the radiation dose values. This will contribute to establishing national DRLs for Colombia in the near future.

Low-Power Highly Robust Resistance-to-Period Converter.

This paper presents a novel structure of Resistance- to-Period (R-T) Converter highly robust to supply and temperature variations. Robustness is achieved by using the ratiometric approach so that complex circuits or high accuracy voltage references are not necessary. To prove the proposed architecture of R-T converter, a prototype was implemented in a 0.18 µ m CMOS process with a single supply voltage of 1.8 V and without any stable reference voltage. Experimental results show a maximum ±1.5% output signal variation for ±10% supply voltage variation and in a 3⁻95 ° C temperature range.

Desalination of sea water with aquatic lily (Eichhornia crassipes).

During the last decades, methods of halo conditioning have been developed to increase the tolerance to salinity in glucophyta crops. Some experiments have carried out the application of hydrogen peroxide (H2O2), in support to the modification of cell tolerance in saline medium. The first objective of this study was to evaluate the effects of the incorporation of H2O2 in salinity tolerance development of the aquatic lily (Eichhornia crassipes). Results showed that the incorporation of 0.03 % H2O2 salinity tolerance developed in salt concentrations similar to seawater. Saline stress tolerance in aquatic lily was shown by the excretion of salts in its leaves; this process helped also in removing salt from seawater. At the same time, the reproduction of the lily is intimately linked to the content of nitrogen (N) and phosphorus (P) (nutrients) in water. This reason is important to control the concentrations of these elements in the water. This will allow maintaining a control in the dissemination of the lily. Considering the mentioned above, the second objective was to continue development of the adaptation of the aquatic lily in seawater, using H2O2 and the required amount of nutrients. This paper points out the importance of considering a biological process for the treatments in the desalination of seawater, making the process more sustainable.

Hyperandrogenism Accompanies Increased Intra-Abdominal Fat Storage in Normal Weight Polycystic Ovary Syndrome Women.

CONTEXT: Normal weight polycystic ovary syndrome (PCOS) women may have altered adipose structure-function underlying metabolic dysfunction. OBJECTIVE: This study examines whether adipose structure-functional changes exist in normal weight PCOS women and correlate with hyperandrogenism and/or hyperinsulinemia. DESIGN: This is a prospective cohort study. SETTING: The setting was an academic medical center. PATIENTS: Six normal weight PCOS women and 14 age- and body mass index-matched normoandrogenic ovulatory (NL) women were included. INTERVENTION(S): All women underwent circulating hormone and metabolic measurements; frequently sampled intravenous glucose tolerance testing; total body dual-energy x-ray absorptiometry; abdominal magnetic resonance imaging; and SC abdominal fat biopsy. MAIN OUTCOME MEASURE(S): Circulating hormones and metabolites, body fat and its distribution, and adipocyte size were compared between PCOS and NL women, and were correlated with each other in all women. RESULTS: Circulating LH and androgen levels were significantly greater in PCOS than NL women, as were fasting insulin levels, pancreatic ß-cell responsiveness to glucose, and total abdominal fat mass. Intra-abdominal fat mass also was significantly increased in PCOS women and was positively correlated with circulating androgen, fasting insulin, triglyceride, and non-high-density lipoprotein cholesterol levels in all women. SC abdominal fat mass was not significantly increased in PCOS women, but contained a greater proportion of small SC abdominal adipocytes that positively correlated with serum androgen levels in all women. CONCLUSION: Hyperandrogenism in normal weight PCOS women is associated with preferential intra-abdominal fat deposition and an increased population of small SC abdominal adipocytes that could constrain SC adipose storage and promote metabolic dysfunction.

Yoga Empowers Seniors Study (YESS): Design and Asana Series.

The practice of yoga asanas (postures) may be an optimal method of preserving or enhancing physical function in older men and women. However, the physical demands, efficacy and safety of an asana practice for seniors have not been well studied. The Yoga Empowers Seniors Study (YESS) is an intervention development study that created two senior-adapted series of asanas targeted for an ambulatory older population. YESS is using biomechanics and physical performance tests to acquire information about the physical demands placed on the muscles and joints by the asanas and the functional performance adaptations resulting from the yoga practice. This manuscript details the standardized, senior-adapted, YESS asana series and the additional asana modifications provided when participants had physical limitations. This presentation will enable the yoga research and teaching communities to interpret the biomechanics, physical performance and side effects outcomes of YESS.

Síndrome mielodisplásico revisión bibliográfica actual y su tratamiento homeopático / Current literature review myelodysplastic syndrome and its homeopathic treatment

Los Síndromes Mielodisplásicos (MDS) constituyen un grupo de trastornos clonales caracterizados por citopenias progresivas, dishematopoyesis y su riesgo a progresar a leucemia mieloide aguda. La etiología de los MDS primarios es desconocida y los secundarios pueden deberse al uso de agentes antineoplásicos, productos químicos y radio o quimioterapia. Su fisiopatologia incluye la alteración de la hematopoyesis, que puede acompañarse de alteraciones citogenéticas, moleculares e inmunológicas. El diagnóstico es la afectación de al menos el 10% de las células en cada una de las series (dishematopoyesis). En el 80 % de las biopsias de médula ósea se observan signos de desorganización en la arquitectura hematopoyética habitual. En el diagnóstico diferencial están los procesos com alteraciones mielodisplásicas como las anemias por deficiência de vitamina B12, ácido fólico o piridoxina, las hepatopatias crónicas, la anemia de las enfermedades crónicas, el tratamiento con quimioterapia, la infección por VIH y la aplasia medular, entre otros. El tratamiento alopático es tóxico que em pocas ocasiones mejora la calidad de vida, sólo el trasplante de médula ósea. La terapéutica Homeopática, en cambio, estimula y modula la hematopoyesis, logrando así mejoría y em gran cantidad de los pacientes remisión de su estado.

Síndrome mielodisplásico revisión bibliográfica actual y su tratamiento homeopático / Current literature review myelodysplastic syndrome and its homeopathic treatment

Los Síndromes Mielodisplásicos (MDS) constituyen un grupo de trastornos clonales caracterizados por citopenias progresivas, dishematopoyesis y su riesgo a progresar a leucemia mieloide aguda. La etiología de los MDS primarios es desconocida y los secundarios pueden deberse al uso de agentes antineoplásicos, productos químicos y radio o quimioterapia. Su fisiopatologia incluye la alteración de la hematopoyesis, que puede acompañarse de alteraciones citogenéticas, moleculares e inmunológicas. El diagnóstico es la afectación de al menos el 10% de las células en cada una de las series (dishematopoyesis). En el 80 % de las biopsias de médula ósea se observan signos de desorganización en la arquitectura hematopoyética habitual. En el diagnóstico diferencial están los procesos com alteraciones mielodisplásicas como las anemias por deficiência de vitamina B12, ácido fólico o piridoxina, las hepatopatias crónicas, la anemia de las enfermedades crónicas, el tratamiento con quimioterapia, la infección por VIH y la aplasia medular, entre otros. El tratamiento alopático es tóxico que em pocas ocasiones mejora la calidad de vida, sólo el trasplante de médula ósea. La terapéutica Homeopática, en cambio, estimula y modula la hematopoyesis, logrando así mejoría y em gran cantidad de los pacientes remisión de su estado.(AU)