RESUMO
Tumor tissue repositories (TTRs) play a pivotal role in both basic and translational research by acting as a conduit to facilitate innovative research, thereby providing solutions to treat the incurable disease--'Cancer'. One of the fundamental requirements to achieve this goal would be the acquisition of high quality tumor tissue specimens that are stored in such a manner that its integrity is preserved. Further, a quality system should be in place that assures the compliance of procedures that are the key to a smooth functioning of all the inter-related departments that play a key role in the entire operations. To address this, we have initiated an effort to build a tumor tissue repository of brain tumor tissues in the Southern part of the Indian sub-continent. One of the cardinal features of brain tumors is the heterogeneity, both phenotypically and genotypically. Moreover, significant gaps exist in current understanding of the molecular pathways involved in the genesis, progression, and biological and clinical behavior of brain tumors. We hope that our initiative will provide researchers accessibility to a reserve of high quality tissues in this part of the globe. We have created and validated a complete histology service including tissue processing, embedding, sectioning and H&E staining for fixed tissues, in addition to creating and staining frozen sections. To our knowledge, such a structured initiative to store brain tumor samples is the first of its kind in the India.
Assuntos
Pesquisa Biomédica/organização & administração , Neoplasias Encefálicas/patologia , Controle de Qualidade , Bancos de Tecidos/organização & administração , Bancos de Tecidos/normas , Adulto , Idoso , Idoso de 80 Anos ou mais , Biomarcadores Tumorais/genética , Biomarcadores Tumorais/metabolismo , Pesquisa Biomédica/ética , Neoplasias Encefálicas/genética , Neoplasias Encefálicas/metabolismo , Criança , Criopreservação , Feminino , Humanos , Técnicas Imunoenzimáticas , Masculino , Pessoa de Meia-Idade , RNA Mensageiro/genética , RNA Neoplásico/genética , Reação em Cadeia da Polimerase Via Transcriptase Reversa , Manejo de Espécimes , Doadores de Tecidos , Adulto JovemAssuntos
Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Infecções por Citomegalovirus/etiologia , Gastrite/etiologia , Linfoma Anaplásico de Células Grandes/complicações , Estrongiloidíase/etiologia , Adulto , Albendazol/uso terapêutico , Anti-Helmínticos/uso terapêutico , Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Antivirais/uso terapêutico , Bleomicina/administração & dosagem , Bleomicina/efeitos adversos , Ciclofosfamida/administração & dosagem , Ciclofosfamida/efeitos adversos , Infecções por Citomegalovirus/tratamento farmacológico , Doxorrubicina/administração & dosagem , Doxorrubicina/efeitos adversos , Doenças Endêmicas , Ganciclovir/uso terapêutico , Gastrite/tratamento farmacológico , Gastrite/parasitologia , Gastrite/virologia , Humanos , Hospedeiro Imunocomprometido , Imunossupressores/efeitos adversos , Leucovorina/administração & dosagem , Leucovorina/efeitos adversos , Linfoma Anaplásico de Células Grandes/tratamento farmacológico , Masculino , Metotrexato/administração & dosagem , Metotrexato/efeitos adversos , Omã , Prednisolona/administração & dosagem , Prednisolona/efeitos adversos , Prednisona/administração & dosagem , Prednisona/efeitos adversos , Indução de Remissão , Estrongiloidíase/tratamento farmacológico , Vincristina/administração & dosagem , Vincristina/efeitos adversosRESUMO
A 45-year-old diabetic man presented with an episodic history of painless gross hematuria. He had had no previous urinary symptoms or any other medical problems. His physical examination, urine cytology, and computed tomography scan findings were normal. Cystoscopy demonstrated two nodular masses in the urinary bladder with a hemorrhagic mucosal surface. Biopsies revealed amyloidosis, and immunohistochemical staining of the specimens defined the process as amyloid AA (mostly seen in secondary amyloidosis). The workup for systemic conditions associated with amyloid AA was negative. This represents an unusual case of primary localized AA-type amyloidosis of the bladder.