RESUMO
Blood samples were collected from Gadaba, a tribal population of Andhra Pradesh, South India, in order to examine the distribution of blood groups, red cell enzymes and the gammaglobulin polymorphism. Out of 20 genetic markers studied seven protein loci exhibited monomorphism. Surprisingly a case of a rare homozygous variant and twenty-one heterozygous variants at the phosphogluconate dehydrogenase locus (6-PGD), six variants at the phosphohexose isomerase locus (PHI) and a single case of phosphoglucomutase locus 1 (PGM 1) variant were observed. Further, the tribal populations of South India reveal higher frequencies of rare variants than the caste populations. However, the presence of rare variants that are phenotypically neutral may be plausibly due to their high selective value.
Assuntos
Etnicidade/genética , Genética Populacional , Adolescente , Adulto , Eritrócitos/enzimologia , Etnicidade/estatística & dados numéricos , Marcadores Genéticos , Variação Genética , Humanos , Índia , Pessoa de Meia-Idade , Polimorfismo Genético , População Rural/estatística & dados numéricosRESUMO
A total of 998 unrelated individuals from the Gadaba tribal population of Andhra Pradesh, South India, were screened for red cell phosphohexose isomerase (PHI) by starch gel electrophoresis. A new and hitherto for Andhra Pradesh not yet reported rare variant phenotype was observed: PHI 6-1. The new allele is designated as PHI*6Gadaba.
Assuntos
Etnicidade/genética , Variação Genética/genética , Glucose-6-Fosfato Isomerase/genética , Fenótipo , Alelos , Eritrócitos/enzimologia , Frequência do Gene/genética , Genética Populacional , Humanos , ÍndiaRESUMO
Blood samples from 1000 unrelated, adult individuals of the Gadaba tribal population were screened for 6-phosphogluconate dehydrogenase. We report the occurrence of a new fast moving variant, which is caused by the allele PGD* Gadaba. This allele is reported for the first time among the tribal populations of Andhra Pradesh. Its frequency comes to 0.0115, and it was observed in heterozygous (2.10%) and homozygous (0.10%) conditions.
Assuntos
Países em Desenvolvimento , Eritrócitos/enzimologia , Etnicidade/genética , Fenótipo , Fosfogluconato Desidrogenase/genética , Adulto , Alelos , Feminino , Frequência do Gene/genética , Variação Genética , Genética Populacional , Heterozigoto , Homozigoto , Humanos , Índia , MasculinoRESUMO
A total of 436 Jalari families, a fishing caste population of Visakhapatnam in Andhra Pradesh, India, are surveyed for thirteen anthropometric measurements. Heritability coefficients (h2) of these anthropometric measurements are calculated using Fisher (1918) and Penrose (1971) formulae. The longitudinal measurements record highest heritability coefficients followed by breadth measurements and circumferences. The heritability coefficients of all the measurements, calculated by using Penrose's method show relatively higher values than Fisher's method.
