Magnetic Fe3O4 nanoparticles loaded guava leaves powder impregnated into calcium alginate hydrogel beads (Fe3O4-GLP@CAB) for efficient removal of methylene blue dye from aqueous environment: Synthesis, characterization, and its adsorption performance.

In the present work, a novel Fe3O4-GLP@CAB was successfully synthesized via a co-precipitation procedure and applied for the removal of methylene blue (MB) from aqueous environment. The structural and physicochemical characteristics of the as-prepared materials were explored using a variety of characterization methods, including pHPZC, XRD, VSM, FE-SEM/EDX, BJH/BET, and FTIR. The effects of several experimental factors on the uptake of MB using Fe3O4-GLP@CAB were examined through batch experiments. The highest MB dye removal efficiency of Fe3O4-GLP@CAB was obtained to be 95.2 % at pH 10.0. Adsorption equilibrium isotherm data at different temperatures showed an excellent agreement with the Langmuir model. The adsorption uptake of MB onto Fe3O4-GLP@CAB was determined as 136.7 mg/g at 298 K. The kinetic data were well-fitted by the pseudo-first-order model, indicating that physisorption mainly controlled it. Several thermodynamic variables derived from adsorption data, like as ΔGo, ΔSo, ΔHo, and Ea, accounted for a favourable, spontaneous, exothermic, and physisorption process. Without seeing a substantial decline in adsorptive performance, the Fe3O4-GLP@CAB was employed for five regeneration cycles. Because they can be readily separated from wastewater after treatment, the synthesized Fe3O4-GLP@CAB was thus regarded as a highly recyclable and effective adsorbent for MB dye.

Removal of anionic (Acid Yellow 17 and Amaranth) dyes using aminated avocado (Persea americana) seed powder: adsorption/desorption, kinetics, isotherms, thermodynamics, and recycling studies.

Aminated avocado seed powder (AASP)-an eco-friendly novel adsorbent has been used for the removal of Acid Yellow 17 (AY 17) and Amaranth (AMR) from an aqueous phase. The AASP (before and after adsorption) was systematically characterized by different analytical techniques such as FT-IR, FESEM, EDX, and N2 adsorption-desorption analysis. Non-linear form of various kinetic (PFO and PSO) and isotherm (Langmuir and Freundlich) models were used to examine the adsorption behavior of AY 17 and AMR onto AASP. The adsorption of AY 17 and AMR onto AASP was well illustrated by the PSO kinetic model and Langmuir isotherm models. At 303 K, the maximum adsorption capacities (obtained from the Langmuir) of the AASP for AY 17 and AMR was 42.7 and 89.2 mg/g, respectively. The AY 17 and AMR adsorption was strongly pH-dependent with an optimum pH value of 2.0. Activation energy was calculated as 12.3 and 16.3 kJ/mol for AY 17 and AMR respectively, suggesting physical adsorption. The positive values of ΔGo and ΔHo indicated that the adsorption process of AY 17 and AMR onto AASP was non-spontaneous and endothermic. The negligible loss of adsorption capacity and excellent regeneration of AASP were observed for the five cycles. Statement of novelty: The present research majorly focused on the synthesis of adsorbent from Avocado seed for the removal of Acid Yellow 17 and Amaranth anionic dyes from aqueous solution. Although the literature is available on direct seed powder as adsorbent, to the best of our knowledge, no chemical modified adsorbent synthesis was not available. Hence, to fill the gap in the literature, we chose the following study that significantly enhanced the adsorption efficiency of the selected anionic dyes.

Novel pyranopyrazole derivatives comprising a benzoxazole core as antimicrobial inhibitors: Design, synthesis, microbial resistance and machine aided results.

From a medical point of view lot of existing antibiotics became unusable because microbial gained strong antibiotic resistance. The combination of two compounds in one core may lead to kill such type of pathogens. Herein, we developed pyranopyrazole derivatives comprising benzoxazole moiety by green approach strategy and studied their antimicrobial performance on four bacteria and two fungi. As a result, most of the compounds delivered reliable toxicity to kill the pathogens. In those,6aexhibited considerable activity against the microbial pathogens. Moreover,compounds 6d, 6l,and6nshowed prominent antibacterial activity. In addition, molecular docking studies of docked compounds revealed the strong bonding interaction with DNA-Gyrase and were docked into the intercalation location of DNA of the DNA-gyrase complex. The molecule bounded to the DNA stabilized by the H bonds, hydrophobic interactions, and π-π interaction. In addition, the linked 5-chlorobenazoxazole structure stabilized by the DT-8 and DG2009 of the F chain with pi-pi interactions. From the computer-aided results, it was observed that compound6a demonstrated maximum docking score -10.0 kcal/mole towards DNA-gyrase. Overall, this investigation suggested that these biologically active compounds can be utilized as leads for preclinical studies with the goal of developing newer antimicrobial drugs.

Impregnation of magnetic - Momordica charantia leaf powder into chitosan for the removal of U(VI) from aqueous and polluted wastewater.

Uranium (U(VI)) is radioactive and the primary raw material in the production of nuclear energy. Hence the research associated with uranium removal gained a lot of importance because to reduce the threat of uranium contamination to ecology and its environment surroundings. Thus, economically as well as environmentally friendly sorbents with a good sorption capacity have to be acquired for the removal of U(VI) pollutants from the aqueous and polluted sea samples. In this study magnetic- Momordica charantia leaf powder impregnated into chitosan (m-MCLPICS) was prepared through the impregnation method. After preparation the adsorbent undergone through various characterizations such as BET, XRD, FTIR, SEM with elemental mapping, and VSM analysis. The specific surface area (93.12 m2/g), pore size (0.212 cm3/g) and pore volume (15.35 nm) of m-MCLPICS was obtained from the BET analysis. A pH value of 5 and 0.5 g of adsorbent dose were selected as an optimum values for U(VI) removal. Kinetic data follows the pseudo-second-order model, and the equilibrium data fitted well with the Langmuir isotherm model. ΔG° (-1.6999, -2.4994, -3.5476 and -4.5147 kJ/mol), ΔH0 (25.1 kJ/mol) and ΔS0 (0.089 kJ/mol K) indicates that the U(VI) sorption process is feasible, spontaneous and endothermic.

Adsorptive removal of anionic dye (Reactive Black 5) from aqueous solution using chemically modified banana peel powder: kinetic, isotherm, thermodynamic, and reusability studies.

The removal of Reactive Black 5 (RB5) using chemically modified banana peel powder (CMBPP) from aqueous solution was dealt with in the present investigation. Factors affecting the adsorption of RB5 (like pH solution, agitation speed, initial concentration of RB5, contact time and temperature) were investigated. FTIR, SEM-EDX, BET and Elemental analysis characterized the adsorbent material. Adsorption kinetic results evaluated by non-linear pseudo-second-order model was fitted well and showed good correlation with the experimental data than the pseudo-first-order model. The experimental equilibrium data evaluated by non-linear Langmuir, Freundlich, Dubinin-Radushkevich (D-R), and Temkin equations and the experimental data were well described by the Langmuir isotherm model. Langmuir monolayer sorption capacity of RB5 onto CMBPP was observed at pH 3.0 (211.8 mg/g). The values of thermodynamic parameters revealed that the sorption process was feasible, spontaneous, endothermic, and physisorption in nature, i.e. (ΔG° <0, ΔH° > 0, and ΔS° > 0). Desorption studies reveal that the maximum recovery of RB5 when 0.1 M NaOH solution used as a desorbent. The CMBPP also exhibited excellent regeneration efficiency for the five cycles of successive adsorption-desorption. The results exposed that CMBPP could use as a prospective adsorbent material for the removal of RB5 from aqueous media.

Phytochemistry and pharmacological activities of the genus Rhynchosia: a comprehensive review.

MAIN CONCLUSION: The genus Rhynchosia is a rich source of natural compounds especially flavonoids and prenylated isoflavonoids. Further experimental studies on Rhynchosia members may be result new and novel secondary metabolites with potent biological activities. Traditionally, medicinal plants have played a significant role on human life since ancient days. At present, natural compounds are the major source for the modern drug discovery owing to their therapeutic selectivity, minutest of side effects, inexpensive source and serve as lead molecules for the discovery of new drugs. Rhynchosia species (Fabaceae) are extensively circulated throughout the tropical and subtropical areas around the world. A few plants of this genus were used in traditional medicine for the treatment of various ailments such as antibacterial, antidiabetic, abortifacients, healing of wounds, hepatoprotective, remedial of boils, rheumatic pains and skin infections. The present review compiles traditional uses, isolated chemical compounds and pharmacological activities of Rhynchosia species. So far, in total, seventy-seven compounds were isolated from the genus Rhynchosia, including flavonoids, isoflavonoids, flavan-3-ols, xanthones, biphenyls, simple polyphenols and sterols. It is interesting to note that the genus Rhynchosia is a rich source of C-glycosylflavonoids and prenylated isoflavonoids. Further, phytochemical and pharmacological studies on this genus are required since only few species have been investigated so far.

Modification of chitosan macromolecule and its mechanism for the removal of Pb(II) ions from aqueous environment.

It is well-known that heavy metals are non-biodegradable and have been showing remarkable impacts on the environment, public health and economics. Because of high toxic tendency, lead (Pb), is one of the foremost considerable hazardous metal with high environmental impacts. Chitosan is a polysaccharide, and can be utilized in wastewater treatment because of its good sorption ability. Amino and hydroxyl groups (C-3 position) on chitosan can serve as electrostatic interaction and complexation sites for metal cations. Chemical crosslinking can effectively enhance the stability of chitosan in acidic media. Hence a novel, cost-effective and eco-friendly ZnO incorporated into aminated chitosan Schiff's base (ACSSB@ZnO) has been synthesized, characterized (BET, XRD, FTIR, SEM, TEM and 1H NMR), and utilized as an adsorbent for the removal of Pb(II) ions from the aqueous environment. The various operating parameters, such as pH (2-8), agitation speed (30-180), adsorbent dose (0.1-0.8 g), contact time (0-140 min), metal ion concentration and temperature (303-323 K) were investigated. The maximum sorption capacity of Pb(II) onto ACSSB@ZnO was found to be 55.55 mg/g. The equilibrium, and kinetic studies suggested that the adsorption process followed the Langmuir isotherm and Pseudo-Second-Order model. Thermodynamic data showed that the sorption process was feasible, spontaneous, and endothermic.

Pyranopyrazoles as efficient antimicrobial agents: Green, one pot and multicomponent approach.

Innovative therapeutic heterocycles having precisely thiadiazolyl-pyranopyrazole fragments were prepared by using the ecofriendly synthetic route. Entire compounds formed in quantitative yields. All the composites tested for their antimicrobial effectiveness against four microbial, two beneficial fungi's and accurately measured the minimum inhibitory concentrations (MIC and MBC/MFC), along with some initial structure activity relationships (SARs) also discussed. From the biological outcomes, the motif 6f provided an outstanding activity against all six pathogens. The possible presence of a nitro substituent on this composite may undoubtedly enhance the activity. In addition, amalgams 6d, 6g and 6l displayed promising antimicrobial results. This may be justified to the presence of electron capture group attached to the benzene ring, while the combinations 6j and 6k were zero effect towards all bacterial strains. The other compounds were excellent to low antimicrobial efficiency. The intriguing point was observed that all the active compounds had in common immense antibacterial effectiveness on Gram-negative bacteria than Gram-positive one and more antifungal activity on A. niger compare to other fungus. All things considered and suggested that this outstanding green synthetic approach is used to develop biological active compounds. On top of that, biological results confirmed that these biologically energetic motifs suitable for additional preclinical examine with the aim of standing novel innovative drugs.

Removal of Pb(II) ions from aqueous media using epichlorohydrin crosslinked chitosan Schiff's base@Fe3O4 (ECCSB@Fe3O4).

Lead is one of the highly toxic metals reaching the water bodies from industries and discarded domestic wastes. Chitosan and its derivatives can be used to modify magnetic materials to promote the adsorption properties of the magnetic materials for the removal of metal ions. The obtained ECCSB@Fe3O4 was characterized by XRD, FTIR, SEM, TEM and VSM analysis. The effect of solution pH, adsorbent dosage, contact time, initial metal ion concentration and temperature effect was studied. The results of the batch sorption kinetic experiments were substituted into the pseudo-first order, pseudo-second order and intraparticle diffusion models. The R2 and SSE results show that pseudo-second order equation describes the sorption process very well. Adsorption process revealed that the initial uptake of Pb(II) was rapid and equilibrium was achieved within 105 min. Langmuir and Freundlich adsorption isotherm models were applied to represent adsorption isotherm data. The equilibrium data were well fitted by the Langmuir isotherm model by revealing the maximum sorption capacity value 86.20 mg/g of ECCSB@Fe3O4. Different thermodynamic parameters, namely, changes in standard Gibbs energy, enthalpy, and entropy, were also evaluated from the temperature dependence, and the results suggest that the adsorption reaction is spontaneous and endothermic in nature.

Synthesis, antimicrobial activity and advances in structure-activity relationships (SARs) of novel tri-substituted thiazole derivatives.

Trisubstituted thiazoles were synthesized and studied for their antimicrobial activity and supported by theoretical calculations. In addition, MIC, MBC and MFC were also tested. Moreover, the present study was analyzed to scrutinize comprehensive structure-activity relationships. In fact, LUMO orbital energy and orbital orientation was reliable to explain their antibacterial and antifungal assay. Amongst the tested compounds, tri-methyl-substituted thiazole compound showed higher antimicrobial activity and low MIC value due to highest LUMO energy.

Synthesis, antioxidant, and cytotoxic activities of N-azole substituted thiomorpholine derivatives.

A new class of N-azole substituted thiomorpholine derivatives were prepared and their antioxidant and cytotoxic activities were studied. The methyl substituted oxazolyl thiomorpholine dioxide 9b exhibited radical scavenging activity greater than the standard ascorbic acid. On the other hand, the thiazolyl thiomorpholine 10c having a chloro substituent on the aromatic ring was identified as a remarkable lead molecule for cytotoxic activity against A549 and HeLa cells, with IC50 values of 10.1 and 30.0 µM, respectively.