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Bioorg Med Chem Lett
; 20(8): 2609-13, 2010 Apr 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20231096
RESUMO
We have designed and synthesized a novel series of 2,8-diaryl-quinoxalines as Janus kinase 2 inhibitors. Many of the inhibitors show low nanomolar activity against JAK2 and potently suppress proliferation of SET-2 cells in vitro. In addition, compounds from this series have favorable rat pharmacokinetic properties suitable for in vivo efficacy evaluation.