RESUMO
The modern level of knowledge on the etiology and pathogenesis of periodontal disease identifies microbial factor as the dominant cause of the development of aggressive and typical forms of periodontitis. The study involved 125 patients with chronic generalized periodontitis and aggressive forms of periodontitis divided in 2 groups. The treatment tactics was chosen selectively depending on the amount of periodontopathogenic microorganisms revealed by real-time PCR. In patients treated with antibiotics this amount decreased significantly resulting in clinical improvement and rapid remission.
Assuntos
Periodontite Agressiva/microbiologia , Bactérias/classificação , Periodontite Crônica/microbiologia , Boca/microbiologia , Adolescente , Adulto , Periodontite Agressiva/diagnóstico , Periodontite Agressiva/tratamento farmacológico , Antibacterianos/uso terapêutico , Bactérias/efeitos dos fármacos , Bactérias/isolamento & purificação , Periodontite Crônica/diagnóstico , Periodontite Crônica/tratamento farmacológico , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Reação em Cadeia da Polimerase em Tempo Real , Adulto JovemRESUMO
The inflammatory diseases of periodont are a serious medical social problem. The OHIP-14, the questionnaire concerning the quality of life is one of the most applied in stomatology. In stomatology, the most frequently applied questionnaire concerning life quality is OHIP-14. The patients participated in the study were divided on three groups depending on tactics of treatment. The application of comprehensive periodontological treatment enhances the life quality on all scales both in patients with severe chronic periodontitis and in patients with aggressive periodontitis. The life quality enhanced the most in patients underwent repeatedly the supportive therapy.
Assuntos
Periodontite/psicologia , Qualidade de Vida , Adolescente , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Periodontite/classificação , Periodontite/epidemiologia , Prevalência , Federação Russa/epidemiologia , Inquéritos e Questionários , Adulto JovemRESUMO
Levels of IL-1beta, IL-6, TNFalpha, IL-10 and TGF-beta in blood and wound of 56 patients with odontogenic phlegmons in dynamic of infection process were expected. In accordance with known facts production of proinflammatory cytokines (IL-1beta, IL-6, TNFalpha in blood in acute phase of the inflammation process was much more intensive than in normal conditions. Increased proinflammatory cytokines generation led to significant raising of IL-10 concentration, but elevation of its level in blood was only at the 10-14 the days of therapy. The dynamic of these cytokines concentrations in wound were similar. On other side the negative role in regeneration of wound plays TGFbeta. Minimal concentration of this cytokine in blood was found at 1-3 from treatment beginning. On the background of the intensive therapy the level of TGFbeta raised fastly and at 10-14 days was much more than in control conditions. Wound level of TGFbeta was more than in normal conditions from the third day. These changes may be one of the reason of hyper proliferation of keratinocytes, that led rough scars.