Quantitative imaging performance of frequency-tunable capacitive micromachined ultrasonic transducer array designed for intracardiac application: Phantom study.

Commercially available intracardiac echo (ICE) catheters face a trade-off between viewing depth and resolution. Frequency-tunable ICE probes would offer versatility of choice between penetration or resolution imaging within a single device. In this phantom study, the imaging performance of a novel, frequency-tunable, 32-element, 1-D CMUT array integrated with front-end electronics is evaluated. Phased-array ultrasound imaging with a forward-looking CMUT probe prototype operated beyond collapse mode at voltages up to three times higher than the collapse voltage (-65 V) is demonstrated. Imaging performance as a function of bias voltage (-70 V to -160 V), transmit pulse frequency (5-25 MHz), and number of transmit pulse cycles (1-3) is quantified, based on which penetration, resolution, and generic imaging modes are identified. It is shown that by utilizing the concept of frequency tuning, images with different characteristics can be generated trading-off the resolution and penetration depth. The penetration mode provides imaging up to 71 mm in the tissue-mimicking phantom, axial resolution of 0.44 mm, and lateral resolution of 0.12 rad. In the resolution mode, axial resolution of 0.055 mm, lateral resolution of 0.035 rad, and penetration depth of 16 mm are measured. These results show what this CMUT array has the potential versatile characteristics needed for intracardiac imaging, despite its relatively small transducer aperture size of 2 mm × 2 mm imposed by the clinical application.

Penetration and delivery characteristics of repetitive microjet injection into the skin.

Drugs can be delivered transdermally using jet injectors, which can be an advantageous route compared to oral administration. However, these devices inject large volumes deep into the skin or tissues underneath the skin often causing bruising and pain. This may be prevented by injecting smaller volumes at lower depth in a repetitive way using a microjet injection device. Such a device could be used to apply drugs in a controllable and sustainable manner. However, the efficacy of microjet injection has been rarely examined. In this study, the penetration and delivery capacity was examined of a repetitive microjet injection device. Various experiments were performed on epidermal and full-thickness ex vivo human as well as ex vivo porcine skin samples. Results revealed that microjets with a velocity exceeding 90m/s penetrated an epidermal skin sample with a delivery efficiency of approximately 96%. In full-thickness human skin, the delivery efficiency drastically decreased to a value of approximately 12%. Experiments on full-thickness skin revealed that the microjets penetrated to a depth corresponding to the transition between the papillary and reticular dermis. This depth did not further increase with increasing number of microjets. In vivo studies on rats indicated that intact insulin was absorbed into the systemic circulation. Hence, the microjet injection device was able to deliver medication into the skin, although the drug delivery efficiency should be increased.