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1.
Acta Paediatr ; 111(2): 424-431, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-34586680

RESUMO

AIM: The potential for immunotherapy to prevent asthma development has become a hot topic. This prompted us to revisit data from an early study that examined allergic sensitisation on bronchial hyperresponsiveness (BHR) in children with and without respiratory symptoms. Unlike previous studies, it used both indirect and direct test methods. METHODS: The study was conducted in Kuopio, Finland, in 1994 and 247 children (55.1% boys) with a mean age 10.5 ± 1.7 years were recruited using a school survey: 165 with lower respiratory symptoms and 82 healthy controls. Each child underwent a 6-min free-running test and a methacholine test with a cumulative dose of 4900 µg. All participants underwent skin-prick tests: 127were sensitised and 120 were non-sensitised. RESULTS: There were no significant differences in lung function between the sensitised and non-sensitised children. However, sensitisation was associated with BHR which was measured by both the methacholine test (2400 µg versus >4900 µg, p < 0.001) and the free-running test (-3.5% versus -2.6%, p = 0.042). No such differences were observed among the healthy controls. Sensitisation was a predictor of allergic diseases, and only multisensitisation to a minimum of four allergens increased the incidence of asthma. CONCLUSION: Allergic sensitisation did not affect BHR in children without respiratory symptoms.


Assuntos
Asma , Hiper-Reatividade Brônquica , Hiper-Reatividade Brônquica/diagnóstico , Testes de Provocação Brônquica , Criança , Feminino , Humanos , Masculino , Cloreto de Metacolina , Sistema Respiratório , Testes Cutâneos
2.
Acta Paediatr ; 100(9): e106-11, 2011 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-21401715

RESUMO

AIM: There is a need for markers of Th1 and Th2 imbalance in diseases such as asthma. CD30 is an activation marker of Th2 cells, and importance of Th1 marker CD26 was recently found in adult asthma. We studied whether serum-soluble CD30 (sCD30) or serum-soluble CD26 (sCD26) could support early diagnosis of asthma in children at school age. METHODS: sCD26 and sCD30 were measured in 34 children with clinically confirmed asthma, 31 with possible asthma and in 147 controls. In addition, the associations of flow volume spirometry, methacholine inhalation challenge and free running test results with serum sCD26 or sCD30 were analysed. RESULTS: Serum sCD30 was significantly higher in children with confirmed asthma (mean 91.5 IU/mL, SD 23.0) than in the controls (78.8 IU/mL, 25.9; p = 0.042). No significant differences were found in serum sCD26 levels between the groups. There was a negative correlation of mean mid expiratory flow values with serum sCD26 (r = -0.22, p = 0.0018). Neither methacholine inhalation challenge nor free running test results were associated with serum sCD26 or sCD30. CONCLUSION: Serum sCD30 was higher in children with asthma. However, marked overlap in serum sCD30 between asthmatic and healthy children limits the usefulness of sCD30 as a diagnostic marker of asthma.


Assuntos
Resistência das Vias Respiratórias , Asma/sangue , Hiper-Reatividade Brônquica/sangue , Dipeptidil Peptidase 4/sangue , Antígeno Ki-1/sangue , Pulmão/patologia , Adolescente , Fatores Etários , Análise de Variância , Asma/diagnóstico , Asma/imunologia , Biomarcadores/sangue , Hiper-Reatividade Brônquica/diagnóstico , Hiper-Reatividade Brônquica/imunologia , Estudos de Casos e Controles , Criança , Feminino , Humanos , Pulmão/fisiologia , Masculino , Análise Multivariada , Espirometria , Estatísticas não Paramétricas , Inquéritos e Questionários , Células Th1/imunologia
3.
Ann Med ; 37(1): 26-32, 2005.
Artigo em Inglês | MEDLINE | ID: mdl-15902844

RESUMO

The prevalence of childhood asthma has increased throughout the last decades, but the reasons for the increase still remain unresolved. However, the debate has recently focused on the role of infections, and microbial exposure in general, in the development of childhood asthma. Many studies have suggested that there is an inverse relation between certain infections and the risk of asthma. This article outlines the contemporary role of childhood asthma in public health, reviews the importance of topical respiratory pathogens in the development of childhood asthma, and provides an example how selection bias may have caused controversy in previous studies assessing the role of infections in the development of childhood asthma.


Assuntos
Asma/etiologia , Infecções Respiratórias/complicações , Anticorpos Antibacterianos , Asma/epidemiologia , Asma/imunologia , Bactérias/imunologia , Bactérias/patogenicidade , Criança , Saúde Global , Humanos , Incidência , Prevalência , Infecções Respiratórias/microbiologia , Infecções Respiratórias/prevenção & controle , Linfócitos T Auxiliares-Indutores/imunologia
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