Longitudinal manipulation of local nonseparability in vector beams.

The inherent nonseparability of vector beams presents a unique opportunity to explore novel optical functionalities, expanding new degrees of freedom for optical information processing. In this Letter, we introduce a novel, to the best of our knowledge, method for tailoring the local nonseparability along the propagation axis of vector beams. Employing higher-order Bessel vector beams, the longitudinal control over the local nonseparability is achieved through targeted amplitude modulation of constituent orthogonal polarization components within the main ring region. Experimental demonstrations of diverse longitudinal nonseparability profiles corroborate the efficacy and versatility of our approach, opening avenues for further exploration of the nonseparability manipulation in vector beams.

Single-shot measurement of the Jones matrix for anisotropic media using four-channel digital polarization holography.

Dynamic measurement of the Jones matrix is crucial in investigating polarization light fields, which have wide applications in biophysics, chemistry, and mineralogy. However, acquiring the four elements of the Jones matrix instantly is difficult, hindering the characterization of random media and transient processes. In this study, we propose a single-shot measurement method of the Jones matrix for anisotropic media called "four-channel digital polarization holography" (FC-DPH). The FC-DPH system is created by a slightly off-axis superposition of reference light waves, which are modulated by a spatial light modulator (SLM), and signal light waves that pass through a Ronchi grating. The SLM enables flexible adjustment of the spatial carrier frequency, which can be adapted to different anisotropic media. The four elements of the Jones matrix can be obtained from the interferogram through the inverse Fourier transform. Optical experiments on anisotropic objects validate the feasibility and accuracy of the proposed method.

Spatio-temporal structuring control of a vectorial focal field.

Focal field modulation has attracted a lot of interest due to its potential in many applications such as optical tweezers or laser processing, and it has recently been facilitated by spatial light modulators (SLMs) owing to their dynamic modulation abilities. However, capabilities for manipulating focal fields are limited by the space-bandwidth product of SLMs. This difficulty can be alleviated by taking advantage of the high-speed modulation ability of digital micromirror devices (DMDs), i.e., trading time for space to achieve fine focus shaping. In this paper, we propose a new, to the best of our knowledge, technique for achieving four-dimensional focal field modulation, which allows for independent manipulation of the focal field's parameters (including amplitude, phase, and polarization) in both the space and time domains. This technique combines a DMD and a vector field synthesis system based on a 4-f system. The high-speed modulation ability of DMDs enables versatile focus patterns to be fast switchable during the exposure time of the detector, forming multiple patterns in a single recording frame. By generating different kinds of focal spots and lines at different moments during the exposure time of the detector, we can finally get complete multifocal spots and lines. Our proposed method is effective at improving the flexibility and speed of the focal field modulation, which is beneficial to applications.

Multidimensional spatial monitoring of open pit mine dust dispersion by unmanned aerial vehicle.

Dust pollution is one of the most severe environmental issues in open pit mines, hindering green mining development. Open pit mine dust has characteristics of multiple dust-generating points, is irregular, influenced by climatic conditions, and has a high degree of distribution with a wide dispersion range in three dimensions. Consequently, evaluating the quantity of dust dispersion and controlling environmental pollution are crucial for supporting green mining. In this paper, dust monitoring above the open pit mine was carried out with an unmanned aerial vehicle (UAV) on board. The dust distribution patterns above the open pit mine were studied in different vertical and horizontal directions at different heights. The results show that the temperature changes less in the morning and more at noon in winter. At the same time, the isothermal layer becomes thinner and thinner as the temperature rises, which makes it easy for dust to spread. The horizontal dust is mainly concentrated at 1300 and 1550 elevations. The dust concentration is polarized at 1350-1450 elevation. The most serious exceedance is at 1400 elevation, with TSP (the concentration of total suspended particulate), PM10 (particulates with aerodynamic diameter < 10 µm), and PM2.5 (particulates with aerodynamic diameter < 2.5 µm) accounting for 188.8%, 139.5%, and 113.8%, respectively. The height is 1350-1450 elevation. Dust monitoring technology carried out by UAV can be applied to the study of dust distribution in the mining field, and the research results can provide reference for other open pit mines. It can also provide a basis for law enforcement part to carry out law enforcement, which has expanded and wide practical application value.

Experimental Demonstration of Quantum Pseudotelepathy.

Quantum pseudotelepathy is a strong form of nonlocality. Different from the conventional nonlocal games where quantum strategies win statistically, e.g., the Clauser-Horne-Shimony-Holt game, quantum pseudotelepathy in principle allows quantum players to with probability 1. In this Letter, we report a faithful experimental demonstration of quantum pseudotelepathy via playing the nonlocal version of Mermin-Peres magic square game, where Alice and Bob cooperatively fill in a 3×3 magic square. We adopt the hyperentanglement scheme and prepare photon pairs entangled in both the polarization and the orbital angular momentum degrees of freedom, such that the experiment is carried out in a resource-efficient manner. Under the locality and fair-sampling assumption, our results show that quantum players can simultaneously win all the queries over any classical strategy.

MnO2-melittin nanoparticles serve as an effective anti-tumor immunotherapy by enhancing systemic immune response.

Cancer vaccines are viewed as a promising immunotherapy to eradicate malignant tumors and aim to elicit the patients' own tumor-specific immune response against tumor cells. However, few cancer vaccines have been applied due to the low immunogenicity of antigen and invalidation of adjuvant. Herein, we designed a tumor microenvironment (TME) responsive MnO2-melittin nanoparticles (M-M NPs). The M-M NPs consumed glutathione and produced •OH via Fenton-like reaction in the mimic TME, specifically caused tumor cell death in vitro, activated cGAS-STING pathway in vitro and promoted the maturation of antigen-presenting cells in vitro and in vivo to elicit systemic anti-tumor immune response including the augmentation of tumor-specific T cells and more productions of pro-inflammatory cytokines and chemokines, which all were stronger than MnO2 NPs and melittin. The anti-tumor effects of M-M NPs were evaluated in three subcutaneous tumor models and the B16-F10 lung metastasis model and the tumor growth and lung metastasis were more obviously inhibited in the M-M NPs treated mice, compared with MnO2 NPs and melittin treatments. More importantly, only M-M NPs promoted the MHC-I cross-dressing by dendritic cells to prime tumor-specific CD8+ T cells and remarkably suppressed the growth of left tumors if express cognate antigen while treating on the right in the bilateral tumor model. Our findings proposed a strategy to enhance the cancer vaccine efficiency which showed great therapeutic effect on tumor immunotherapy.

Ceria nanoparticles prophylactic used for renal ischemia-reperfusion injury treatment by attenuating oxidative stress and inflammatory response.

Renal ischemia-reperfusion (IR) injury (RIRI) is the leading cause of acute kidney injury (AKI), a common disease with high morbidity and mortality. However, due to the lack of effective diagnostic and therapeutic tools, patients have to resort to conservative treatment. To address this issue, we have developed a novel prophylactic strategy that involves the pre-treatment use of ceria nanoparticles (CNPs) before surgery. Based on our careful study of the three different sizes of CNPs that we synthesized, 46 nm (NP46), 81 nm (NP81), and 118 nm (NP118), we have found that NP118 can be used as effective prophylactic agents against RIRI and subsequent renal fibrosis. In our experiments, the CNPs exhibited excellent antioxidant and anti-inflammatory activities in vitro and effectively protected the kidney against RIRI and renal fibrosis in vivo, as proved by the decreases in renal lesions, serum creatinine, blood urea nitrogen, apoptotic cell, KIM-1 expression, and fibrotic area in CNPs treated samples relative to RIRI group. Mechanistically, not only did the CNPs reduce oxidative stress by regulating the Nrf2 pathway, but they also attenuated RIRI induced inflammatory response by decreasing macrophage infiltration and polarization to M1 phenotype, and reducing pro-inflammatory cytokine and chemokine production. In vitro results further confirmed that CNPs pre-treatment not only dramatically decreased intracellular ROS production in renal tubular epithelial cells and vascular endothelial cells, but also effectively attenuated lipopolysaccharide-induced inflammation in RAW264.7 cells. In addition, we found that one fourth of the NP118 persisted for more than 21 days in IR kidneys, and that out of the three sizes of CNPs, NP118 achieved the best results in all our experiments. Our study provides new insights into the usage and majorization of CNPs as a potential therapy to treat or prevent RIRI and renal fibrosis.

Experimental self-testing for photonic graph states.

Graph states-one of the most representative families of multipartite entangled states-are important resources for multiparty quantum communication, quantum error correction, and quantum computation. Device-independent certification of highly entangled graph states plays a prominent role in quantum information processing tasks. Here we have experimentally demonstrated device-independent certification for multipartite graph states by adopting the robust self-testing scheme based on scalable Bell inequalities. Specifically, the prepared multi-qubit Greenberger-Horne-Zeilinger (GHZ) states and linear cluster states achieve a high degree of Bell violation, which are beyond the nontrivial bounds of the robust self-testing scheme. Furthermore, our work paves the way to the device-independent certification of complex multipartite quantum states.

Hong-Ou-Mandel Interference between Two Hyperentangled Photons Enables Observation of Symmetric and Antisymmetric Particle Exchange Phases.

Two-photon Hong-Ou-Mandel (HOM) interference is a fundamental quantum effect with no classical counterpart. The existing research on two-photon interference was mainly limited in one degree of freedom (DOF); hence, it is still a challenge to realize quantum interference in multiple DOFs. Here, we demonstrate HOM interference between two hyperentangled photons in two DOFs of polarization and orbital angular momentum (OAM) for all 16 hyperentangled Bell states. We observe hyperentangled two-photon interference with a bunching effect for ten symmetric states (nine boson-boson states and one fermion-fermion state) and an antibunching effect for six antisymmetric states (three boson-fermion states and three fermion-boson states). More interestingly, expanding the Hilbert space by introducing an extra DOF for two photons enables one to transfer the unmeasurable external phase in the initial DOF to a measurable internal phase in the expanded two DOFs. We directly measured the symmetric exchange phases being 0.012±0.002, 0.025±0.002, and 0.027±0.002 in radian for the three boson states in OAM and the antisymmetric exchange phase being 0.991π±0.002 in radian for the other fermion state, as theoretical predictions. Our Letter may not only pave the way for more wide applications of quantum interference, but also develop new technologies by expanding Hilbert space in more DOFs.

Radially self-accelerating Stokes vortices in nondiffracting Bessel-Poincaré beams.

We theoretically propose and experimentally generate the nondiffracting Bessel-Poincaré beams whose Stokes vortices radially accelerate during propagation. To this end, we design the Bessel beams whose intensity is specified to be uniformly distributed along the longitudinal direction. By superposing two such Bessel beams having different helical phases and mutually orthogonal polarizations, the synthesized vector beam is endowed with the polarization singularity that can rotate about the optical axis, while the total intensities maintain their profiles. Radially self-accelerating Stokes vortices in the resulting beam can be manipulated by adjusting the predefined parameters in the constituent beams.

Optical frequency conversion of light with maintaining polarization and orbital angular momentum.

Optical frequency conversion provides a fundamental and important approach to manipulate light in frequency domain. In such a process, manipulating the frequency of light without changing information in other degrees of freedom of light will enable us to establish an interface between various optical systems operating in different frequency regions and have many classical and quantum applications. Here we experimentally demonstrate a frequency conversion with maintaining polarization and orbital angular momentum (OAM) by successfully upconverting various polarization-OAM composite states in a nonlinear Sagnac interferometer. Our scheme offers a new possibility for building different wave band interfaces in more degrees of freedom.

Twin curvilinear vortex beams.

We report on a novel curvilinear optical vortex beam named twin curvilinear vortex beams (TCVBs) with intensity and phase distribution along a pair of two- or three-dimensional curves, both of which share the same shape and the same topological charge. The TCVBs also possess the character of perfect optical vortex, namely having a size independent of topological charge. We theoretically demonstrate that a TCVB rather than a single-curve vortex beam can be created by the Fourier transform of a cylindrically polarized beam. The behavior of TCVBs generated through our method is investigated by simulation and experiment, including interference experiments for identifying the vortex property of the TCVBs. The TCVBs may find applications in optical tweezers, such as trapping low refractive index particles in the dark region between two curves and driving them moving along the curvilinear trajectory.

Non-diffracting and self-accelerating Bessel beams with on-demand tailored intensity profiles along arbitrary trajectories.

Owing to their robustness against diffraction, Bessel beams (BBs) offer special advantages in various applications. To enhance their applicability, we present a method to generate self-accelerating zeroth-order BBs along predefined trajectories with tunable z direction intensity profiles. The character of tunable z direction intensity profiles in non-diffracting self-accelerating BBs potentially can attract interest in the regimes of particle manipulation, microfabrication, and free-space optical interconnects.

Theoretical analysis based on mirror symmetry for tightly focused vector optical fields.

A theoretical analysis based on mirror symmetry is proposed to analyze and predict the symmetry in intensity, phase and polarization distributions of the tightly focused vector optical field (VOF). We extend the analysis to more cases including more complicated polarization states and weak focusing cases. We further show the symmetric tightly focused fields of the eccentric cylindrical VOF and the redesigned VOF with a radially variant polarization state, which are achieved by redesigning the polarization state of the incident VOF based on the symmetry analysis. We also take the laser fabrication as an example to further show how to apply this symmetry analysis in a specific application area. Such a theoretical analysis can improve the calculation efficiency, provide new insights into the tight focusing process and offer a convenient way to engineer the field distributions in the focal plane, which may have potential applications in areas needing flexibly controllable tightly focused fields, such as laser fabrication, optical trapping, and optical storage.

Measuring spatial coherence by using a lateral shearing interferometry.

A modified lateral shearing interferometry is proposed to measure the spatial coherence of partially coherent light beams. This interferometry based on a 4f system consists of a diffraction grating and a spatial light modulator (SLM). In this system, the diffraction grating splits the partially coherent wave into two copied waves, forming a shearing interferogram on the observation plane. The period of the composite blazing grating generated by the phase-modulated SLM is flexibly tuned for controlling the lateral displacement of the two copied waves. The complex degree of spatial coherence of the partially coherent field is obtained through measurements and Fourier analysis of the fringe pattern.

Arbitrarily tunable orbital angular momentum of photons.

Orbital angular momentum (OAM) of photons, as a new fundamental degree of freedom, has excited a great diversity of interest, because of a variety of emerging applications. Arbitrarily tunable OAM has gained much attention, but its creation remains still a tremendous challenge. We demonstrate the realization of well-controlled arbitrarily tunable OAM in both theory and experiment. We present the concept of general OAM, which extends the OAM carried by the scalar vortex field to the OAM carried by the azimuthally varying polarized vector field. The arbitrarily tunable OAM we presented has the same characteristics as the well-defined integer OAM: intrinsic OAM, uniform local OAM and intensity ring, and propagation stability. The arbitrarily tunable OAM has unique natures: it is allowed to be flexibly tailored and the radius of the focusing ring can have various choices for a desired OAM, which are of great significance to the benefit of surprising applications of the arbitrary OAM.

Generalized Poincaré sphere.

We present a generalized Poincaré sphere (G sphere) and generalized Stokes parameters (G parameters), as a geometric representation, which unifies the descriptors of a variety of vector fields. Unlike the standard Poincaré sphere, the radial dimension in the G sphere is not used to describe the partially polarized field. The G sphere is constructed by extending the basic Jones vector bases to the general vector bases with the continuously changeable ellipticity (spin angular momentum, SAM) and the higher dimensional orbital angular momentum (OAM). The north and south poles of different spherical shells in the G sphere represent the pair of different orthogonal vector basis with different ellipticity (SAM) and the opposite OAM. The higher-order Poincaré spheres are just the two special spherical shells of the G sphere. We present a quite flexible scheme, which can generate all the vector fields described in the G sphere.

Elliptic-symmetry vector optical fields.

We present in principle and demonstrate experimentally a new kind of vector fields: elliptic-symmetry vector optical fields. This is a significant development in vector fields, as this breaks the cylindrical symmetry and enriches the family of vector fields. Due to the presence of an additional degrees of freedom, which is the interval between the foci in the elliptic coordinate system, the elliptic-symmetry vector fields are more flexible than the cylindrical vector fields for controlling the spatial structure of polarization and for engineering the focusing fields. The elliptic-symmetry vector fields can find many specific applications from optical trapping to optical machining and so on.

Vector optical fields with bipolar symmetry of linear polarization.

We focus on a new kind of vector optical field with bipolar symmetry of linear polarization instead of cylindrical and elliptical symmetries, enriching members of family of vector optical fields. We design theoretically and generate experimentally the demanded vector optical fields and then explore some novel tightly focusing properties. The geometric configurations of states of polarization provide additional degrees of freedom assisting in engineering the field distribution at the focus to the specific applications such as lithography, optical trapping, and material processing.

Femtosecond laser processing by using patterned vector optical fields.

We present and demonstrate an approach for femtosecond laser processing by using patterned vector optical fields (PVOFs) composed of multiple individual vector optical fields. The PVOFs can be flexibly engineered due to the diversity of individual vector optical fields in spatial arrangement and distribution of states of polarization, and it is easily created with the aid of a spatial light modulator. The focused PVOFs will certainly result in various interference patterns, which are then used to fabricate multi-microholes with various patterns on silicon. The present approach can be expanded to fabricate three-dimensional microstructures based on two-photon polymerization.