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1.
Workplace Health Saf ; 70(12): 556-565, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-36000700

RESUMO

BACKGROUND: New graduate role transition for nurses and teachers is stressful. Poor adaptation may manifest as insomnia, which has implications for the new professionals, their employers, and the public served. This study examines factors that impact new graduate sleep, with the aim of identifying perceived helps and hindrances to sleep-during-transition. METHODS: Targeted content analysis of transcripts from a larger longitudinal mixed methods study comparing new graduate sleep during their first year of practice. Study participants (N = 21) answered questions in the final interview regarding the most positive and negative impact(s) on sleep during the transition year. Transcripts were analyzed and compared based on the new graduate sleep typology (i.e., Got Better, Got Worse, Stayed Varied) which emerged from the parent study. FINDINGS: Most participants, regardless of sleep type, identified a person/group as most positively impacting sleep. They identified work thoughts, stress/anxiety, people, work hours/sleep schedules, and environmental factors as negatively impacting sleep. Work thoughts and stress/anxiety were mentioned together and most frequently by participants in all three sleep types. CONCLUSION/APPLICATIONS TO PRACTICE: This study provided insight into new graduate nurse and teacher sleep during transition. Support persons and/or groups may be essential regardless of sleep type. Thought management/stress mitigation strategies and good sleep hygiene may also improve the sleep experiences of these new professionals. Occupational health nurses can support sleep-during-transition among new nurses and teachers by acting as sleep advocates. They may also identify a need for medical intervention and/or sleep specialists and should promote fatigue risk mitigating policies.


Assuntos
Enfermeiras e Enfermeiros , Sono , Humanos , Fadiga
2.
Workplace Health Saf ; 69(10): 448-454, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34167400

RESUMO

BACKGROUND: In the United States, millions of people contract the flu each year. Immunization has been shown to provide the best protection against the flu. Increasing flu vaccination rates can reduce the number of patients who get the flu and seek care for non-specific symptoms thus making detection of the coronavirus more efficient. METHOD: A quality improvement project was implemented to increase the number of influenza vaccines received by employees at an onsite employer-based health clinic. Anonymous pre- and post-surveys were used to assess the flu knowledge of employees. Employees from a large financial group, who voluntarily participated, received an educational handout at the onsite health fair or at a lunch and learn. Full-time employees who carried their employer's health insurance were eligible to participate, whereas, dependents and contract employees were excluded. FINDINGS: The number of employees who received the vaccination increased during the fall of 2019 (n = 406) when compared with the previous year (n = 337). Nineteen percent (n = 170) of employees completed surveys. There were statistically significantly more post- than pre-survey responses reflecting the participants' perceived knowledge of influenza and the flu vaccine. The majority of participants in both the pre- and post-surveys reported that they learned "a lot" about both influenza and the flu vaccine. CONCLUSION: Providing education and access to the vaccine in the workplace may improve flu knowledge, reduce barriers, and increase flu vaccine uptake among employees.


Assuntos
Programas de Imunização/organização & administração , Influenza Humana/prevenção & controle , Serviços de Saúde do Trabalhador/organização & administração , Vacinação/estatística & dados numéricos , Adulto , Idoso , Conhecimentos, Atitudes e Prática em Saúde , Humanos , Vacinas contra Influenza/imunologia , Pessoa de Meia-Idade , Melhoria de Qualidade , Inquéritos e Questionários , Vacinação/economia , Adulto Jovem
3.
J Occup Environ Hyg ; 18(7): 334-344, 2021 07.
Artigo em Inglês | MEDLINE | ID: mdl-34080950

RESUMO

Homemade cloth masks and other improvised face coverings have become widespread during the COVID-19 pandemic driven by severe shortages of personal protective equipment. In this study, various alternative (mostly common household) materials, which have not traditionally been used in respiratory protective devices, were tested for particle filtration performance and breathability. Most of these materials were found of some-but rather limited-utility in facemasks. At a breathing flow rate of 30 L min-1, 17 out of 19 tested materials demonstrated collection efficiency below 50%; at 85 L min-1, only one material featured particle collection efficiency above 50%. Pressure drop values were mostly below 4 mm w.g. (observed in 89% of cases for the two flow rates), which provides comfortable breathing. Only for one fabric material (silk) tested at 85 L min-1 did the pressure drop reach 11 mm w.g. Based on these results, a three-layer facemask prototype was designed and fabricated comprised of the best performing materials. Additional tests were conducted to examine possible particle detachment/shedding from the materials used in the newly developed facemask, but no such phenomenon was observed. The prototype was evaluated on 10 human subjects using the standard OSHA-approved quantitative fit testing protocol. The mask protection level, determined as an adopted fit factor, was found to lie between that of the two commercial surgical/medical masks tested for comparison. A 10-cycle washing of the mask prototype lowered its collection efficiency across the particle size range; however, washing did not substantially affect mask breathability. The study revealed that although homemade masks offer a certain level of protection to a wearer, one should not expect them to provide the same respiratory protection as high-end commercial surgical/medical masks or-by any means-NIOSH-certified N95 filtering facepieces.


Assuntos
COVID-19/prevenção & controle , Desenho de Equipamento , Filtração/instrumentação , Máscaras/normas , Teste de Materiais , Humanos , Máscaras/provisão & distribuição , Exposição Ocupacional/prevenção & controle , Tamanho da Partícula , Equipamento de Proteção Individual/normas , Equipamento de Proteção Individual/provisão & distribuição , Respiração , Dispositivos de Proteção Respiratória/normas , Dispositivos de Proteção Respiratória/provisão & distribuição , SARS-CoV-2 , Têxteis
4.
J Nurs Educ Pract ; 11(9): 29-38, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-35371370

RESUMO

Background: The rapidly growing number of home healthcare workers (HHCW) are exposed to unique occupational hazards within each patient home. This article describes the development of an observation tool to document occupational hazards HHCWs encounter. Methods: Tool development followed three steps: determining content domain, content validity, and inter-rater agreement. Results: Expert feedback guided the revision of content domain to 636 items. Scale level content validity index (S-CVI) was 0.90. Inter-rater agreement tests resulted in percent agreement and accuracy mean of 89.5% and frequency variables resulted in standard deviations from 0 to 8.62. Conclusions: The observation tool encompasses the diverse range of occupational hazards HHCWs encounter; inter-rater percent agreement and overall accuracy scores were acceptable. Future pilot testing of this tool among broader raters and populations is recommended to characterize its usability, internal consistency, and reliability to assess HHCW occupational hazards.

5.
Regul Toxicol Pharmacol ; 106: 251-261, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31047944

RESUMO

Home healthcare is a growing area of employment. Assessment of occupational health risks to home health care workers (HHCWs) is important because in many cases the unique characteristics of the home environment do not facilitate the level of exposure control afforded to caregivers in hospitals and other fixed patient care sites. This assessment is focused on health risks to HHCWs from exposure to pharmaceutical drugs used to treat asthma and other respiratory diseases, which are commonly administered to patients in aerosolized form via nebulizers. We developed risk-based exposure limits for workers in the form of occupational exposure limits (OEL) values for exposure to nebulized forms of the three most common drugs administered by this method: albuterol, ipratropium, and budesonide. The derived OEL for albuterol was 2 µg/day, for ipratropium was 30 µg/day, and for budesonide was 11 µg/day. These OELs were derived based on human effect data and adjusted for pharmacokinetic variability and areas of uncertainty relevant to the underlying data (human and non-human) available for each drug. The resulting OEL values provide an input to the occupational risk assessment process to allow for comparisons to HHCW exposure that will guide risk management and exposure control decisions.


Assuntos
Budesonida/análise , Pessoal de Saúde , Ipratrópio/análise , Exposição Ocupacional/análise , Saúde Ocupacional , Budesonida/efeitos adversos , Budesonida/farmacocinética , Humanos , Ipratrópio/efeitos adversos , Ipratrópio/farmacocinética , Exposição Ocupacional/efeitos adversos , Medição de Risco
6.
Work ; 62(3): 373-382, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30856143

RESUMO

BACKGROUND: More than 13 million employees are working in the public education sector which includes more than just teachers in the United States. This industry sector also employs custodians, maintenance, and administration. To date, there is very limited information about the type and frequency of injuries for these employees. OBJECTIVE: To identify injury trends related to frequency and severity for different occupational injuries in a large urban school district. METHODS: Between 2014-2015, school district employees reported a total of 598 occupational injuries. Initial analysis of the data provided the frequency of injuries overall and for individual occupational categories. The Severity Index provides a score for job category and injury type based on severity and frequency. RESULTS: Overall, the Slip, Trip and Fall category had the highest frequency, followed by Combative Situations, and Over-exertion. Teacher and Para-professional workers experienced the greatest number of injuries with violence being the most frequent cause. Based on the Severity Index, Over-exertion was identified as the primary exposure concern for Custodians, while Slip, Trip and Fall category had the greatest impact on Building Engineers. CONCLUSIONS: With the diversity of negative outcomes, the administration will need targeted interventions for the various professions represented in the school systems. The injury severity profile indicates non-teachers should be a high priority for interventions with over-exertion and slips, trips and falls leading the risk.


Assuntos
Traumatismos Ocupacionais/epidemiologia , Instituições Acadêmicas/estatística & dados numéricos , Acidentes por Quedas/estatística & dados numéricos , Humanos , Remoção/efeitos adversos , Meio-Oeste dos Estados Unidos/epidemiologia , Setor Público/organização & administração , Setor Público/estatística & dados numéricos , Retorno ao Trabalho/estatística & dados numéricos , Instituições Acadêmicas/organização & administração , Índice de Gravidade de Doença , Violência/estatística & dados numéricos
7.
Workplace Health Saf ; 67(4): 153-158, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30761945

RESUMO

Motivating employees to increase their physical activity is a health promotion challenge. A Move-A-Thon (MAT) event approach was implemented as an alternative incentive to help workers to optimize their physical activity levels. We implemented a demonstration project in which workers were incentivized for their participation through monetized donations to charity. Their steps were monitored over the 2-week demonstration period. The MAT goal was for participants to achieve a minimum of 3,000 daily steps for 2 weeks, for which they could earn a total donation of up to US$20. Participants walking at least once with up to five different "exercise buddies" could earn up to US$2 more per buddy for donation. Of 10 workers invited, nine enrolled and eight completed participation by logging their monitored steps across an average of 13.75 full MAT participation days. Participants averaged 9,330.8 steps per day-more than triple the lower threshold required for a maximum US$20 charitable donation. The eight participants walked with a total of 21 "exercise buddies." They were receptive to future MAT events of longer duration. In total, the monetized donation to charity made by those eight participants was US$202. The MAT event participants were successful at promoting physical activity among a small group of workers for 2 weeks. Future worksite health promotion projects with this type of incentive strategy are indicated.


Assuntos
Exercício Físico/psicologia , Promoção da Saúde/métodos , Motivação , Saúde Ocupacional , Humanos , Avaliação de Programas e Projetos de Saúde , Comportamento Sedentário , Caminhada/estatística & dados numéricos
8.
J Sex Med ; 9(5): 1367-73, 2012 May.
Artigo em Inglês | MEDLINE | ID: mdl-22390173

RESUMO

INTRODUCTION: Cycling is associated with genital neuropathies and erectile dysfunction in males. Women riders also have decreased genital sensation; however, sparse information exists addressing the effects of modifiable risks on neurological injuries in females. AIM: This study assesses the effects of bicycle setup and cyclists' attributes on GS and saddle pressures among female cyclists. METHODS: Previously, we compared genital sensation in competitive female cyclists (N = 48) to that of female runners (N = 22). The current study is a subanalysis of the 48 cyclists from the original study group. Nonpregnant, premenopausal women who rode at least 10 miles per week, 4 weeks per month were eligible for participation. MAIN OUTCOME MEASURES: Genital sensation was measured in microns using biosthesiometry measures of vibratory thresholds (VTs). Perineal and total saddle pressures were determined using a specialized pressure map and recorded in kilopascals (kPA). RESULTS: Handlebars positioned lower than the saddle correlated with increased perineum saddle pressures and decreased anterior vaginal and left labial genital sensation (P < 0.05, P < 0.02, P < 0.03, respectively). Low handlebars were not associated with total saddle pressures or altered genital sensation in other areas. After adjusting for age and saddle type, low handlebars were associated with a 3.47-kPA increase in mean perineum saddle pressures (P < 0.04) and a 0.86-micron increase in anterior vagina VT (P < 0.01). CONCLUSION: Handlebars positioned lower than the saddle were significantly associated with increased perineum saddle pressures and decreased genital sensation in female cyclists. Modifying bicycle setup may help alleviate neuropathies in females. Additional research is warranted to further assess the extent of the associations.


Assuntos
Ciclismo/lesões , Diafragma da Pelve/lesões , Adulto , Fatores Etários , Índice de Massa Corporal , Feminino , Genitália Feminina/fisiopatologia , Humanos , Pessoa de Meia-Idade , Períneo/lesões , Sensação/fisiologia , Vagina/fisiopatologia , Adulto Jovem
9.
J Toxicol Environ Health A ; 75(2): 100-11, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-22129237

RESUMO

The aim of this study was to evaluate biomarkers of acrylamide exposure, including hemoglobin adducts and urinary metabolites in acrylamide production workers. Biomarkers are integrated measures of the internal dose, and it is total acrylamide dose from all routes and sources that may present health risks. Workers from three companies were studied. Workers potentially exposed to acrylamide monomer wore personal breathing-zone air samplers. Air samples and surface-wipe samples were collected and analyzed for acrylamide. General-area air samples were collected in chemical processing units and control rooms. Hemoglobin adducts were isolated from ethylenediamine teraacetic acid (EDTA)-whole blood, and adducts of acrylamide and glycidamide, at the N-terminal valines of hemoglobin, were cleaved from the protein chain by use of a modified Edman reaction. Full work-shift, personal breathing zone, and general-area air samples were collected and analyzed for particulate and acrylamide monomer vapor. The highest general-area concentration of acrylamide vapor was 350 µg/cm(3) in monomer production. Personal breathing zone and general-area concentrations of acrylamide vapor were found to be highest in monomer production operations, and lower levels were in the polymer production operations. Adduct levels varied widely among workers, with the highest in workers in the monomer and polymer production areas. The acrylamide adduct range was 15-1884 pmol/g; glycidamide adducts ranged from 17.8 to 1376 p/mol/g. The highest acrylamide and glycidamide adduct levels were found among monomer production process operators. The primary urinary metabolite N-acetyl-S-(2-carbamoylethyl) cysteine (NACEC) ranged from the limit of detection to 15.4 µg/ml. Correlation of workplace exposure and sentinel health effects is needed to determine and control safe levels of exposure for regulatory standards.


Assuntos
Acrilamida/análise , Acrilamida/farmacocinética , Poluentes Ocupacionais do Ar/análise , Poluentes Ocupacionais do Ar/farmacocinética , Ar/análise , Indústria Química , Exposição Ocupacional , Acetilcisteína/análogos & derivados , Acetilcisteína/urina , Acrilamida/sangue , Acrilamida/urina , Adulto , Poluentes Ocupacionais do Ar/sangue , Poluentes Ocupacionais do Ar/urina , Biomarcadores/sangue , Biomarcadores/química , Biomarcadores/urina , Espaços Confinados , Monitoramento Ambiental , Compostos de Epóxi/sangue , Compostos de Epóxi/química , Compostos de Epóxi/urina , Contaminação de Equipamentos , Hemoglobinas/análise , Hemoglobinas/química , Humanos , Limite de Detecção , National Institute for Occupational Safety and Health, U.S. , Material Particulado/análise , Propriedades de Superfície , Estados Unidos , Ventilação
10.
J Sex Med ; 8(11): 3144-53, 2011 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-21834869

RESUMO

INTRODUCTION: There are numerous genital complaints in women cyclists, including pain, numbness, and edema of pelvic floor structures. Debate ensues about the best saddle design for protection of the pelvic floor. AIM: To investigate the relationships between saddle design, seat pressures, and genital nerve function in female, competitive cyclists. METHODS: We previously compared genital sensation in healthy, premenopausal, competitive women bicyclists and runners. The 48 cyclists from our original study comprise the study group in this subanalysis. MAIN OUTCOME MEASURES: Main outcome measures were: (i) genital vibratory thresholds (VTs) determined using the Medoc Vibratory Sensation Analyzer 3000 and (ii) saddle pressures as determined using a specially designed map sensor. RESULTS: More than half of the participants (54.8%) used traditional saddles, and the remainder (45.2%) rode with cut-out saddles. On bivariate analysis, use of traditional saddles was associated with lower mean perineal saddle pressures (MPSP) than riding on cut-out saddles. Peak perineal saddle pressures (PPSP) were also lower; however, the difference did not reach statistical significance. Saddle design did not affect mean or peak total saddle pressures (MTSP, PTSP). Saddle width was significantly associated with PPSP, MTSP, and PTSP but not with MPSP. Women riding cut-out saddles had, on average, a 4 and 11 kPa increase in MPSP and PPSP, respectively, compared with women using traditional saddles (P = 0.008 and P = 0.010), after adjustment for other variables. Use of wider saddles was associated with lower PPSP and MTSP after adjustment. Although an inverse correlation was seen between saddle pressures and VTs on bivariate analysis, these differences were not significant after adjusting for age. CONCLUSION: Cut-out and narrower saddles negatively affect saddle pressures in female cyclists. Effects of saddle design on pudendal nerve sensory function were not apparent in this cross-sectional analysis. Longitudinal studies evaluating the long-term effects of saddle pressure on the integrity of the pudendal nerve, pelvic floor, and sexual function are warranted.


Assuntos
Ciclismo , Adulto , Ciclismo/lesões , Estudos Transversais , Desenho de Equipamento , Feminino , Genitália Feminina/anatomia & histologia , Genitália Feminina/inervação , Humanos , Períneo/anatomia & histologia , Períneo/inervação , Pressão , Vibração
11.
Am J Ind Med ; 52(11): 868-75, 2009 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-19753596

RESUMO

BACKGROUND: Recent surveys suggest nail technicians, particularly artificial nail applicators, have increased respiratory symptoms and asthma risk. METHODS: We examined lung function (n = 62) and a marker of airway inflammation, i.e., exhaled nitric oxide (ENO) (n = 43), in a subset of nail technician and control participants in a pilot health assessment. RESULTS: Bivariate analysis of technicians demonstrated that job latency was inversely correlated with FEV1 percent predicted (FEV1PP) (r = -0.34, P = 0.03) and FVCPP (r = -0.32, P = 0.05). Acrylic gel contact hours were inversely correlated with FEV1PP (r = -0.38, P = 0.02) and FVCPP (r = -0.47, P = 0.003). Current smoking was inversely and significantly (P

Assuntos
Indústria da Beleza , Saúde Ocupacional , Adulto , Testes Respiratórios , Feminino , Humanos , Masculino , Análise Multivariada , Unhas , Óxido Nítrico/análise , Projetos Piloto , Espirometria , Adulto Jovem
12.
J Sex Med ; 3(6): 1018-1027, 2006 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-17100935

RESUMO

INTRODUCTION: Bicycling is associated with neurological impairment and impotence in men. Similar deficits have not been confirmed in women. AIM: To evaluate the effects of bicycling on genital sensation and sexual function in women. METHODS: Healthy, premenopausal, competitive women bicyclists and runners (controls) were compared. MAIN OUTCOME MEASURES: (1) Genital vibratory thresholds (VTs) were determined using the Medoc Vibratory Sensation Analyzer 3000. (2) Sexual function and sexually related distress were assessed by the Dennerstein Personal Experience Questionnaire (SPEQ) and the Female Sexual Distress Scale (FSDS). RESULTS: Forty-eight bicyclists and 22 controls were enrolled. The median age was 33 years. The bicyclists were older, had higher body mass indices (BMIs), were more diverse in their sexual orientation, and were more likely to have a current partner. Bicyclists rode an average of 28.3 +/- 19.7 miles/day (range 4-100), 3.8 +/- 1.5 days/week, for an average of 2.1 +/- 1.8 hours/ride. The mean number of years riding was 7.9 +/- 7.1 years (range 0.5-30). Controls ran an average of 4.65 +/- 2.1 miles/day (range 1.5-8) and 5.0 +/- 1.2 days/week. On bivariate analysis, bicyclists had significantly higher VTs than runners, indicating worse neurological function at all sites (P < 0.05). Multivariate analysis found significant correlations between higher VTs and bicycling at the left and right perineum, posterior vagina, left and right labia. Increasing VTs at the clitoris, anterior vagina, and urethra were associated with age. In bicyclists, there were no correlations between VTs and miles biked per week, duration of riding, or BMI. Composite SPEQ scores indicated normal sexual function in all sexually active subjects. Neither group suffered from sexually related distress. CONCLUSION: There is an association between bicycling and decreased genital sensation in competitive women bicyclists. Negative effects on sexual function and quality of life were not apparent in our young, healthy premenopausal cohort.


Assuntos
Ciclismo , Clitóris/fisiologia , Corrida , Sensação/fisiologia , Vagina/fisiologia , Adulto , Estudos Transversais , Feminino , Humanos , Análise Multivariada , Valores de Referência , Comportamento Sexual , Inquéritos e Questionários , Vibração , Saúde da Mulher
13.
Environ Health Perspect ; 110(8): 805-11, 2002 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-12153763

RESUMO

Hydrocarbons (HCs) found in fuels and solvents are ubiquitous in the environment, yet we know little about their effects on the endocrine system. The objective of this study was to assess the potential reproductive endocrine effects of low-dose HCs encountered by female U.S. Air Force personnel with fuel (primarily JP-8 jet fuel) and solvent exposures (n = 63). We estimated the internal dose of HCs in fuels and solvents by measuring their levels in exhaled breath, including the sum of aliphatic HCs (C6H14-C16H34) and the sum of aromatic HCs (benzene, ethylbenzene, toluene, and m,p,o-xylenes). Adverse outcome measures included urinary endocrine markers that have been associated with nonconceptive (vs. conceptive) menstrual cycles in ovulatory women: lower preovulatory luteinizing hormone (LH) and mid-luteal phase pregnanediol 3-glucuronide (Pd3G) and estrone 3-glucuronide, and higher follicle phase Pd3G. We also obtained reproductive and exposure information from baseline questionnaires and daily diaries. Toluene was the most frequently found analyte in the breath, with values up to 52.0 ppb, and benzene breath levels were up to 97.5 ppb. Regression analysis revealed that preovulatory LH levels were significantly lower (p = 0.007) among women whose total aliphatic HC levels were above the median. The relationship between elevated aliphatic HC exposure and lowered preovulatory LH levels in the present study suggests that compounds in fuels and some solvents may act as reproductive endocrine disruptors. Confirmation of these findings is needed, not only to determine if fuel and solvent exposure may impact other LH-dependent physiologic functions but also to examine effects of fuels and solvents on conception.


Assuntos
Combustíveis Fósseis/efeitos adversos , Hidrocarbonetos/efeitos adversos , Hormônio Luteinizante/análise , Exposição Ocupacional , Solventes/efeitos adversos , Adulto , Testes Respiratórios , Feminino , Humanos , Hidrocarbonetos/análise , Militares , Análise de Regressão , Reprodução/efeitos dos fármacos
14.
Fertil Steril ; 78(2): 383-91, 2002 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-12137878

RESUMO

OBJECTIVE: To compare urinary levels of reproductive hormones in African American and Caucasian women. DESIGN: Cross-sectional study. SETTING: Ten United States Air Force (USAF) bases. PATIENT(S): African American (n = 33) and Caucasian (n = 65) women of reproductive age from a larger study of USAF women (n = 170). INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Urinary endocrine end points: follicular luteinizing hormone (LH), preovulatory LH, level of LH surge peak, early follicular follicle stimulating hormone (FSH), follicular LH:FSH ratio, midluteal FSH, FSH rise before menses, early follicular estrone 3-glucuronide (E(1)3G), midfollicular E(1)3G, periovulatory E(1)3G peak, midluteal E(1)3G, early follicular pregnanediol 3-glucuronide (Pd3G), follicular Pd3G, rate of periovulatory Pd3G increase, E(1)3G:Pd3G on the day of luteal transition, slope of E(1)3G:Pd3G, and midluteal Pd3G. RESULT(S): Relative to Caucasians, African American women had significantly lower follicular phase LH:FSH ratios (mean +/- SD: 0.7 +/- 0.4 vs. 1.0 +/- 0.6), lower follicular phase Pd3G levels (1.0 +/- 0.5 vs. 1.2 +/- 0.8 microg/mg creatinine), and lower rates of periovulatory Pd3G increase (0.5 +/- 0.7 vs. 1.0 +/- 1.2 microg/mg creatinine). CONCLUSION(S): Findings of this analysis should be considered preliminary evidence of racial differences in hormone levels. Future studies are needed to determine whether these differences have clinical significance.


Assuntos
População Negra , Hormônios Esteroides Gonadais/urina , População Branca , Adulto , Estudos Transversais , Feminino , Hormônio Foliculoestimulante/sangue , Gonadotropinas/sangue , Humanos , Hormônio Luteinizante/sangue
15.
Chest ; 121(6): 2044-51, 2002 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-12065376

RESUMO

STUDY OBJECTIVE: This industry-wide longitudinal study examines chest radiographic changes of workers manufacturing refractory ceramic fibers (RCF). DESIGN: Chest radiographs were obtained every 3 years and were interpreted using the 1980 International Labour Organization classification for pneumoconiosis. Three exposure metrics were calculated: duration and latency in a production job, and cumulative exposure (fiber-months per cubic centimeter). PARTICIPANTS: The radiographic survey included 625 current workers at five manufacturing sites and 383 former workers at two of the five sites. MEASUREMENTS AND RESULTS: Pleural changes were seen in 27 workers (2.7%). Of workers with > 20 years of latency from initial production job or 20 years of duration in a production job, 16 workers (8.0%) and 5 workers (8.1%) demonstrated pleural changes, respectively. Results from the cumulative exposure analysis (> 135 fiber-months per cubic centimeter) demonstrated a significant elevated odds ratio (OR) of 6.0 (95% confidence interval [CI], 1.4 to 31.0). The incidence of irregular opacities at profusion categories > or = 1/0 was similar to other nonspecified dust-exposed worker populations at 1.0%, and showed a nonsignificant elevated OR in regard to cumulative fiber exposure of 4.7 (95% CI, 0.97 to 23.5). CONCLUSIONS: RCF are significantly associated with pleural changes that were predominantly pleural plaques, but have not resulted in a statistically significant increase in interstitial changes.


Assuntos
Cerâmica/efeitos adversos , Pneumopatias/diagnóstico por imagem , Fibras Minerais/efeitos adversos , Doenças Profissionais/diagnóstico por imagem , Adulto , Feminino , Humanos , Estudos Longitudinais , Pneumopatias/etiologia , Masculino , Pessoa de Meia-Idade , Doenças Profissionais/etiologia , Estudos Prospectivos , Radiografia
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