RESUMO
AIM: The aim of this work was to study the correlation between the mitochondrial microsatellite, situated between the nucleotides 303 and 315 of the mitochondrial genome and the breast cancer in Tunisia. MATERIALS AND METHODS: We have analyzed, by PCR-sequencing, the polymorphism of a mitochondrial microsatellite in 40 Tunisian patients and 39 healthy Tunisian donors. Comparisons of epidemiologic and sequences data were performed by chi-2 test. RESULTS: We have revealed, for this mitochondrial microsatellite, seven different haplotypes in patients and five different haplotypes in controls. The haplotypic distribution was not significant between patients and controls but a negative association between one of these haplotypes (309+C 315+C) and the lymph node invasion was found. CONCLUSION: The haplotype 309+C 315+C is negatively correlated with lymph node invasion of breast cancer in Tunisia.
Assuntos
Neoplasias da Mama/genética , DNA Mitocondrial/genética , Repetições de Microssatélites/genética , Polimorfismo Genético/genética , Adulto , Idoso , Carcinoma Ductal de Mama/genética , Feminino , Haplótipos/genética , Humanos , Pessoa de Meia-Idade , TunísiaRESUMO
Primary leiomyosarcoma of bone is a very rare tumor. Four cases are reported: 3 tumors were located in the femur and 1 in the talus. Clinical and imaging findings including radiographs, CT, and MRI are described. The final diagnosis was made by histopathological, immunohistochemical, and/or ultrastructural study after biopsy.