RESUMO
In experiments on mice AKR the authors investigated the effects which could be produced by cyclic fasting on the mice survival. It was found that one of the variants of this fasting noticeably prolongs the survival of the animals. The proportion of the animals that died of acute lymphoid leukemia among other causes of death declined.
Assuntos
Jejum/fisiologia , Leucemia Mieloide/imunologia , Periodicidade , Doença Aguda , Animais , Feminino , Imunidade Inata , Masculino , Camundongos , Camundongos Endogâmicos AKRRESUMO
The authors reported the results of retrospective analysis of the level of polyamines in urine and the duration of clinicohematological remission in 25 AL children aged 3 to 14. Of this number 23 patients suffered from acute lymphoblastic leukemia, 2--from acute myeloblastic leukemia. Direct correlation between polyamine changes during a course of chemotherapy and the duration of remission was established. Longer duration was observed in the patients in whom a 2-fold rise of the level of all polyamines, especially spermidine, followed the administration of a cytostatic within the first 24-72 h. On the discontinuation of therapy a certain decrease in polyamine excretion with urine was observed in these children as compared to the level determined on their admission to hospital.
Assuntos
Leucemia Mieloide Aguda/tratamento farmacológico , Poliaminas/urina , Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamento farmacológico , Adolescente , Criança , Pré-Escolar , Humanos , Leucemia Mieloide Aguda/sangue , Leucemia-Linfoma Linfoblástico de Células Precursoras/sangue , Valor Preditivo dos Testes , Prognóstico , Indução de Remissão , Estudos RetrospectivosRESUMO
An investigation was carried out on 59 mice of high leukemic line C-58. It is shown that aseptic inflammation inhibited the leukemic process in mice with transplantable leukemia, stimulated the myeloid sprout of hemopoiesis and suppressed the lymphoid one, and also decreased the spleen and thymus mass.