Assuntos
Carcinoma de Células Renais/diagnóstico , Glicogênio/análise , Corpos de Inclusão Intranuclear/patologia , Neoplasias Renais/diagnóstico , Rim/patologia , Biópsia por Agulha , Carcinoma de Células Renais/patologia , Núcleo Celular/patologia , Diagnóstico Diferencial , Humanos , Rim/citologia , Neoplasias Renais/patologia , Masculino , Pessoa de Meia-Idade , Câncer Papilífero da Tireoide/diagnóstico , Câncer Papilífero da Tireoide/patologia , Neoplasias da Glândula Tireoide/diagnóstico , Neoplasias da Glândula Tireoide/patologiaRESUMO
Phyllodes tumor is a relatively uncommon fibroepithelial neoplasm of the breast characterized by proliferation of both stromal and epithelial elements. Benign phyllodes tumors are distinguished from fibroadenomas by their prominent leaf-like architecture and exaggerated intracanalicular stromal growth pattern. Typically, these lesions affect older natal females; however, we present what we believe is the first reported case of benign phyllodes tumor in a hormonally treated transgender woman.
Assuntos
Antagonistas de Androgênios/efeitos adversos , Neoplasias da Mama/induzido quimicamente , Estrogênios/efeitos adversos , Tumor Filoide/induzido quimicamente , Pessoas Transgênero , Neoplasias da Mama/patologia , Feminino , Humanos , Masculino , Tumor Filoide/patologiaAssuntos
Neoplasias do Apêndice/diagnóstico , Neoplasias das Tubas Uterinas/diagnóstico , Tubas Uterinas/patologia , Neoplasias Peritoneais/diagnóstico , Pseudomixoma Peritoneal/diagnóstico , Neoplasias do Apêndice/patologia , Apêndice/patologia , Biomarcadores Tumorais/análise , Diagnóstico Diferencial , Neoplasias das Tubas Uterinas/patologia , Neoplasias das Tubas Uterinas/secundário , Neoplasias das Tubas Uterinas/cirurgia , Tubas Uterinas/cirurgia , Feminino , Humanos , Imuno-Histoquímica , Metaplasia/diagnóstico , Metaplasia/patologia , Pessoa de Meia-Idade , Neoplasias Peritoneais/patologia , Pseudomixoma Peritoneal/patologia , Pseudomixoma Peritoneal/cirurgia , SalpingectomiaRESUMO
Mucinous tubular and spindle cell carcinoma (MTSCC) is a rare type of kidney tumor with relatively indolent behavior. Non-classic morphological variants have not been well studied and rarely been reported. We report a challenging case MTSCC with a peculiar morphology in a 42-year-old man, arising in a background of end-stage renal disease (ESRD). Predominant areas with extensive papillary architecture, psammoma bodies and stromal macrophageal aggregates, reminiscent of a papillary renal cell carcinoma (papillary RCC), were intermixed with foci that transitioned into a MTSCC-like morphology exhibiting elongated tubules and a low grade spindle cell component in a background of mucinous stroma. Immunohistochemistry demonstrated diffuse positivity for P504s/AMACR and vimentin in tumor cells. Focal positivity for RCC, CD10 and CK7 was also noted. Kidney-specific cadherin, cytokeratin 34betaE12 and TFE3 stains were negative in the tumor. The major differential diagnostic considerations were papillary RCC, clear cell papillary RCC, and Xp11.2 translocation carcinoma. Negative FISH studies for trisomy 7 and 17 in both papillary and spindled components supported the diagnosis of MTSCC. The ultrastructural profile was not entirely indicative of the cellular origin of the tumor. Cytogenetic analysis should be performed in atypical cases of MTSCC for precise diagnosis.