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J Biol Phys ; 45(4): 317-334, 2019 12.
Artigo em Inglês | MEDLINE | ID: mdl-31595390

RESUMO

This paper examines the effect of electromagnetic waves, with maxima in the green or red regions of the spectrum, on the morphofunctional state of multipotent mesenchymal stromal cells. The illumination regimes used in our experiments did not lead to any substantial heating of the samples; the physical parameters of the lighting were carefully monitored. When the samples were illuminated with a green light, no significant photostimulatory effect was observed. Red light, on the other hand, had an evident photostimulatory effect. It is shown that photostimulation with a red light decreases the enzymatic activities of mitochondrial dehydrogenases and enhances the viability of cells, their proliferative activity, and their ability to form bone tissue. It is also established that red light stimulates cell proliferation, while not activating the genes that increase the risk of the subsequent malignant transformation of cells or their death. This paper discusses the possible role of hydrogen peroxide in the processes examined.


Assuntos
Fenômenos Eletromagnéticos , Luz , Células-Tronco Mesenquimais/efeitos da radiação , Animais , Proliferação de Células/efeitos da radiação , Cor , Regulação da Expressão Gênica/efeitos da radiação , Masculino , Células-Tronco Mesenquimais/citologia , Células-Tronco Mesenquimais/metabolismo , Camundongos
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