1.
Bioorg Med Chem Lett
; 18(20): 5541-4, 2008 Oct 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18823779
RESUMO
A series of novel 5-aminomethyl-1H-benzimidazole based inhibitors of Itk were prepared. Structure-activity relationships, selectivity and cell activity are reported for this series. Compound 2, a potent and selective antagonist of Itk, inhibited anti-CD3 antibody induced IL-2 production in vivo in mice.