Assuntos
Dermatite Alérgica de Contato/diagnóstico , Dermatoses Faciais/diagnóstico , Minoxidil/efeitos adversos , Testes do Emplastro/efeitos adversos , Pseudolinfoma/patologia , Dermatite Alérgica de Contato/etiologia , Dermatoses Faciais/etiologia , Feminino , Humanos , Pessoa de Meia-Idade , Pseudolinfoma/etiologia , Dermatopatias/etiologia , Dermatopatias/patologiaAssuntos
Dermatite de Contato/etiologia , Ácido Flufenâmico/análogos & derivados , Transtornos de Fotossensibilidade/induzido quimicamente , Administração Tópica , Adulto , Anti-Inflamatórios não Esteroides/administração & dosagem , Anti-Inflamatórios não Esteroides/efeitos adversos , Feminino , Ácido Flufenâmico/administração & dosagem , Ácido Flufenâmico/efeitos adversos , HumanosRESUMO
X-linked dominant protoporphyria (XLDPP) is a genetic disorder that affects the synthesis of the heme group due to an increase in delta-aminolaevulinate synthase 2 (ALAS2) enzyme activity. Moreover, annular elastolytic giant-cell granuloma (AEGCG) is a rare reactive granulomatous dermatosis, usually associated with actinic damage. An 86-year-old man presented with edematous-erythematous lesions in photoexposed areas of the face and on the dorsum of both hands. Protoporphyrin levels in serum and feces were significantly elevated and a heterozygous frameshift mutation in the exon 11 of the ALAS2 gene: c.1706-1709del (p.Glu569GlyfsX24) was identified. Concomitantly, we observed an annular plaque with raised borders on the back of his right hand, clinically and histologically compatible with a diagnosis of AEGCG. Skin lesions disappeared only upon use of a physical sunscreen. We report two rare photodermatoses in an elderly patient and discuss the significance of dermal elastic fiber damage induced by the XLDPP as a main triggering factor of AEGCG.