[Clinical-pathologoanatomic analysis of post-operative thromboembolism of pulmonary artery]. / Kliniko-patologoanatomicheskii analiz posleoperatsionnoi tromboémbolii legochnoi arterii.

Autopsy and clinical data were analysed for 803 surgical patients whose death was due to pulmonary artery thromboembolism (PAT). PAT was diagnosed intravitally in 32% of the deceased. 87% of the patients with PAT symptoms died within 2 hours. 3/4 of PATs developed in uneventful postoperative period, 1/4--in complications. The cause of PAT in 99.3% of cases were thromboses in vena cava inferior. In 88.3% of cases these thromboses ran latently. Frequency of postoperative PAT as a cause of death was 1.4% in 1972-1973, 2.1% in 1990-1991, 1.3% in 1997. The fall of the death rate is explained by introduction of drug prophylaxis of PAT.

[Functional interactions of components of the adenylate cyclase system in the rat liver after prenatal exposure to gamma irradiation]. / Funktsional'noe vzaimodeistvie komponentov adenilattsiklaznoi sistemy pecheni krys posle prenatal'nogo vozdeistviia gamma-izlucheniia.

The effects of long-term prenatal gamma-radiation (0.5 Gy) on the glucagon signalling through adenylyl cyclase in adult rat liver have been investigated. The coupling of receptor/Gs-protein/adenylyl cyclase was tested using kinetic constants for stimulation of adenylyl cyclase by GTP, Gp(NH)pp, AlF4- and glucagon. The estimated data suggests that prenatal chronic gamma-radiation prompted (i) a decrease in rate of GTP hydrolysis on Gs-protein; (ii) a reduction of glucagon potency to accelerate the exchange GDP for GTP on Gs-protein.

[The iliac vein occlusion]. / Narushenie prokhodimosti podvzdoshnykh ven.

Basing on roentgenological and morphological investigations the causes of the iliac veins passability disorder were studied up. In 45.1% of observations the stenosis was revealed of the left and in 1.2% of the right common iliac vein. Among the stenosis causes were osteal or cartilagenous prominences of vertebral column, intravascular structures (webs, membranes) in the left common iliac vein, the external iliac vein squeeze by internal iliac artery, retroperitoneal fibrosis, the right common iliac artery aneurysm, anomalous branching of parietal pelvic artery.

[Effect of prenatal gamma-irradiation on functional properties of rat liver adenylate cyclase]. / Vliianie vnutriutrobnogo gamma-oblucheniia na funktsional'nye svoistva adenilattsiklazy pecheni krys.

In the present work the effects of long-term prenatal gamma-irradiation (0.5 Gy) on the glucagon signalling through adenylyl cyclase have been investigated. In utero gamma-irradiation resulted in the increase of basal and GTP-stimulated adenylyl cyclase activity, whereas, the adenylyl cyclase response to glucagon was essentially reduced. The comparison of kinetic constants estimated from dose-response data for GTP and glucagon suggests that prenatal chronic irradiation prompted (i) the decrease in rate of GTP hydrolysis on Gs-protein; (ii) the reduction of glucagon potency to accelerate the exchange GDP for GTP on Gs-protein.

[Morphologic changes in the thrombus and venous wall in experimental phleobothrombosis and thrombophlebitis]. / Morfologicheskie izmeneniia v trombe i stenke veny pri éksperimental'nom flebotromboze i tromboflebite.

Phlebothrombosis and thrombophlebitis were induced in dogs by percutaneous intraoperative introduction of thrombotic mass, obtained in vivo (20-40 animal blood per 3-4 ml thrombin solution) into jugular vein and studied in postoperative days 1, 3, 5, 7, 10 and 14 through light microscope. The preparations were stained with hematoxylin and eosin and after Hart, Van-Gieson and MSB. Venous intima was established to alter already on the next day following thrombophlebitis modeling. On d 3 and 5 epithelium desquamation and moderate leukocytic infiltration of media between smooth myocytes were found. On d 7 signs of thrombus organization, i.e. invasion of fibroblastic series cells and small capillaries inside it, were demonstrated. Muscular layer and adventitia display leukocytic infiltration. Venous wall thickens due to disorders of blood passage in vasa vasorum. On d 10 the portion of the thrombus attached to the wall was essentially organized. Fibroblasts and capillaries invade inside the thrombus, connective tissue fibres are formed. Sclerotic changes were noted in adventitia. By the end of the 2nd week venous wall showed muscular layer atrophia and sclerosis. Middle portions of the thrombus were involved in organization, canals lined with endothelium are formed in it. In case of thrombophlebitis changes in thrombus and venous wall develop earlier and are more pronounced.

[Modeling of phlebothrombosis in experimental animals]. / Modelirovanie flebotromboza v éksperimente.

Phlebothrombosis model was elaborated in experiment. The thrombotic mass was obtained in vitro, mixing the blood of animal with thrombin. Retracted thrombus was injected by puncture into previously ligated segment of the dog's v. jugularis externa. The vein's preparation was studied up on 1, 3, 5, 7, 10th and 14th day. Up to 8-10 days the thrombus adherence to the vein wall is friable and it is possible to extract it with the help of balloon catheter. Endothelium desquamation was revealed starting from 3-5th day.

[Effect of single-dose external gamma-irradiation of 0.5 g on the development of rat's embryos]. / Vliianie odnokratnogo vneshnego gamma-oblucheniia v doze 0,5 Gr na razvitie zarodyshei krysy.

Primigravida 4-month rats were exposed to single whole-body external gamma-radiation (137Cs, 0.5 Gy) during organogenesis on days 9 and 15 of pregnancy. The embryotoxic effect of radiation was studied on the 20th day of pregnancy. The irradiation caused significant growth disorders characterized mainly by a nonuniform hypoplasia of fetus organs. This effect was most pronounced in fetuses irradiated on the 15th day of the intrauterine development.

[Changes in the adrenergic structures of the human stellate ganglia in pathological states]. / Izmeneniia adrenergicheskikh struktur zvezdchatykh gangliev cheloveka pri nekotorykh patologicheskikh sostoianiiakh.

Stellate ganglia from patients who had succumbed to various diseases were examined by a fluorescent histochemical technique using 2% glyoxylic acid. Catecholamines were detectable in the major neurons, in small intensely fluorescent cells, and in adrenergic fibers with varicosities at levels that varied with the patient's age, cause of death, duration of the agonal period, the treatment administered, and the time when the material had been taken after death. All adrenergic structures of the ganglia were clearly demonstrable after early autopsies of those who had died suddenly from pulmonary artery thromboembolism in the absence of other abnormalities. The ganglia were found to be greatly depleted of catecholamines in cases of sudden cardiac death in the presence of ischemic heart disease before the development of myocardial infarction as well as in those of rapid death from stroke.