1.
Bioorg Med Chem Lett
; 21(21): 6510-4, 2011 Nov 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21924612
RESUMO
Indole and its derivatives undergo smooth conjugate addition onto en-1,4-dione derived from isatin and acetophenone, in the presence of a catalytic amount of molecular iodine in acetonitrile under mild conditions to afford a novel class of 3-(1-(1H-indol-3-yl)-2-oxo-2-phenylethyl)indolin-2-one derivatives in good yields with high degree of 1,4-selectivity. Some of these compounds are found to exhibit modest antibacterial and antifungal properties.