Electrochemical removal of fluoxetine via three mixed metal oxide anodes and carbonaceous cathodes from contaminated water.

In this work, the fluoxetine (FLX) removal has been studied via the anodic oxidation (AO) process. Anode electrodes were Ti/RuO2, Ti/RuO2-IrO2, and Ti/RuO2-IrO2-SnO2, and cathode electrodes were graphite and carbon nanotubes (CNTs). The performances of electrodes were compared in terms of FLX removal efficiency. As a result, Ti/RuO2-IrO2-SnO2 and CNTs were the optimal anode and cathode, respectively. The properties of the optimal electrodes were investigated using scanning electron microscopy, atomic force microscopy and X-ray diffraction spectroscopy. Cyclic voltammetry analysis was performed to study the electrochemical behavior of electrodes. The effect of current intensity (mA), initial pH, initial FLX concentration (mg/L) and process time (min) on the FLX removal efficiency was investigated and the response surface methodology was applied for the optimization of the AO process. The results showed that at current intensity, pH, initial FLX concentration and process time of 500 mA, 6, 25 mg/L and 160 min, maximum FLX removal efficiency was observed, which was 96.25%. Gas Chromatography-Mass Spectrometry (GC-MS), and total organic carbon (TOC) analysis was determined to evaluate the intermediates, and mineralization efficiency. The TOC removal efficiency was reached 81.51% after 6 h under optimal experimental conditions, indicating the successful removal of the FLX.

Evaluation of a novel bioactive wound dressing: an in vitro and in vivo study.

OBJECTIVE: Hard-to-heal wounds, such as pressure ulcers and diabetic ulcers, are a major challenge for wound dressings. The aim of this study was to develop a bioactive dressing based on polymers and natural materials with unique biological and therapeutic properties. METHOD: The dressing was composed of an active layer containing polyvinyl alcohol (PVA), honey, curcumin and keratin, and an upper layer with lower hydrophilicity comprising PVA to induce flexibility. Physicochemical properties of the dressing were characterised by Fourier transform infrared spectroscopy, field emission scanning electron microscopy, swelling behaviour and antibacterial measurements. A wound healing study was performed using an experimental rat model and two different compositions of the bioactive dressing were compared with a commercial wound dressing (Comfeel, Coloplast, Denmark). Histopathological evaluation was conducted for this purpose. RESULTS: Characterisation results showed that a smooth bilayer film with two homogenous but distinct layers was produced. The dressing also provided adequate moisture to the wound environment without infection and adhesion due to dryness occurring. Our results exhibited significant bactericidal activity against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria and improved the wound healing process without any scarring. Histopathological findings demonstrated a significant higher healing rate in vivo together with well-formed epidermis, granulation tissue formation and tissue contraction, when compared with the commercial wound dressing. CONCLUSION: Our results demonstrated acceptable physical and healing effects for the novel bioactive wound dressing; however, more investigations are recommended.